Tags

Type your tag names separated by a space and hit enter

Increased neural response related to neutral faces in individuals at risk for psychosis.
Neuroimage. 2008 Mar 01; 40(1):289-97.N

Abstract

OBJECTIVE

The reliable discrimination of emotional expressions in faces is essential for adequate social interaction. Deficits in facial emotion processing are an important impairment in schizophrenia with major consequences for social functioning and subjective well-being. Whether neural circuits underlying emotion processing are already altered before illness onset is yet unclear. Investigating neural correlates of emotion processing in individuals clinically at risk for psychosis offers the possibility to examine neural processes unchanged by the manifest disorder and to study trait aspects of emotion dysfunctions.

MATERIAL AND METHODS

Twelve subjects clinically at risk for psychosis and 12 matched control subjects participated in this study. fMRI data were acquired during an emotion discrimination task consisting of standardized photographs of faces displaying different emotions (happiness, sadness, anger, fear) as well as faces with neutral facial expression.

RESULTS

There were no group differences in behavioral performance. Emotion discrimination was associated with hyperactivations in high-risk subjects in the right lingual and fusiform gyrus as well as the left middle occipital gyrus. Further, high-risk compared to control subjects exhibited stronger activation related to neutral faces relative to emotional faces in the inferior and superior frontal gyri, the cuneus, the thalamus and the hippocampus.

CONCLUSIONS

The present study indicates that individuals clinically at risk for psychosis show differences in brain activation associated with processing of emotional and--more pronounced--neutral facial expressions despite an adequate behavioral performance. The proneness to attribute salience to neutral stimuli might indicate a biological risk marker for psychosis.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany. nseiferth@ukaachen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18187342

Citation

Seiferth, Nina Y., et al. "Increased Neural Response Related to Neutral Faces in Individuals at Risk for Psychosis." NeuroImage, vol. 40, no. 1, 2008, pp. 289-97.
Seiferth NY, Pauly K, Habel U, et al. Increased neural response related to neutral faces in individuals at risk for psychosis. Neuroimage. 2008;40(1):289-97.
Seiferth, N. Y., Pauly, K., Habel, U., Kellermann, T., Shah, N. J., Ruhrmann, S., Klosterkötter, J., Schneider, F., & Kircher, T. (2008). Increased neural response related to neutral faces in individuals at risk for psychosis. NeuroImage, 40(1), 289-97. https://doi.org/10.1016/j.neuroimage.2007.11.020
Seiferth NY, et al. Increased Neural Response Related to Neutral Faces in Individuals at Risk for Psychosis. Neuroimage. 2008 Mar 1;40(1):289-97. PubMed PMID: 18187342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased neural response related to neutral faces in individuals at risk for psychosis. AU - Seiferth,Nina Y, AU - Pauly,Katharina, AU - Habel,Ute, AU - Kellermann,Thilo, AU - Shah,N Jon, AU - Ruhrmann,Stephan, AU - Klosterkötter,Joachim, AU - Schneider,Frank, AU - Kircher,Tilo, Y1 - 2007/11/28/ PY - 2007/08/27/received PY - 2007/11/12/revised PY - 2007/11/13/accepted PY - 2008/1/12/pubmed PY - 2008/4/24/medline PY - 2008/1/12/entrez SP - 289 EP - 97 JF - NeuroImage JO - Neuroimage VL - 40 IS - 1 N2 - OBJECTIVE: The reliable discrimination of emotional expressions in faces is essential for adequate social interaction. Deficits in facial emotion processing are an important impairment in schizophrenia with major consequences for social functioning and subjective well-being. Whether neural circuits underlying emotion processing are already altered before illness onset is yet unclear. Investigating neural correlates of emotion processing in individuals clinically at risk for psychosis offers the possibility to examine neural processes unchanged by the manifest disorder and to study trait aspects of emotion dysfunctions. MATERIAL AND METHODS: Twelve subjects clinically at risk for psychosis and 12 matched control subjects participated in this study. fMRI data were acquired during an emotion discrimination task consisting of standardized photographs of faces displaying different emotions (happiness, sadness, anger, fear) as well as faces with neutral facial expression. RESULTS: There were no group differences in behavioral performance. Emotion discrimination was associated with hyperactivations in high-risk subjects in the right lingual and fusiform gyrus as well as the left middle occipital gyrus. Further, high-risk compared to control subjects exhibited stronger activation related to neutral faces relative to emotional faces in the inferior and superior frontal gyri, the cuneus, the thalamus and the hippocampus. CONCLUSIONS: The present study indicates that individuals clinically at risk for psychosis show differences in brain activation associated with processing of emotional and--more pronounced--neutral facial expressions despite an adequate behavioral performance. The proneness to attribute salience to neutral stimuli might indicate a biological risk marker for psychosis. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/18187342/Increased_neural_response_related_to_neutral_faces_in_individuals_at_risk_for_psychosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(07)01047-6 DB - PRIME DP - Unbound Medicine ER -