Tags

Type your tag names separated by a space and hit enter

Body mass and endometrial cancer risk by hormone replacement therapy and cancer subtype.
Cancer Epidemiol Biomarkers Prev. 2008 Jan; 17(1):73-9.CE

Abstract

Epidemiologic studies unequivocally show that greater body mass increases the risk of endometrial cancer, but whether risk varies by use of postmenopausal hormone therapy (HT), location of fat deposition, or cancer subtype is still unclear. We examined these associations among 33,436 postmenopausal women in the Cancer Prevention Study II Nutrition Cohort, who completed questionnaires on diet, lifestyle, and medical history at baseline in 1992. A total of 318 cases were eligible through June 2003. Cox-proportional hazards analyses were used to estimate multivariate-adjusted rate ratios (RR). As expected, adult body mass index (BMI) was a strong predictor of risk [RR, 4.70; 95% confidence interval (CI), 3.12-7.07 for BMI 35+ versus 22.5-25.0, P trend < 0.0001]. Use of estrogen plus progestin postmenopausal HT modified the association. Among never-users, risk was significantly linear across the entire range of BMI examined (RR, 0.51; 95% CI, 0.29-0.92 for <22.5 versus 22.5-25.0; RR, 4.41; 95% CI, 2.70-7.20 for > or =35 versus 22.5-25.0, P trend < 0.0001), but among ever estrogen plus progestin users, the association was not significant (P trend = 1.0; P interaction < 0.0001). We observed no difference in risk according to tendency for central versus peripheral fat deposition. Greater BMI (> or =30 versus <25.0) increased risk of both "type I" (classic estrogen pathway, RR, 4.22; 95% CI, 3.07-5.81) and "type II" (serous, clear cell, and all other high grade) cancers (RR, 2.87; 95% CI, 1.59-5.16). The increased risk of endometrial cancer across the range of BMI in women who never used postmenopausal HT stresses the need to prevent both overweight and obesity in women.

Authors+Show Affiliations

Epidemiology and Surveillance Research, American Cancer Society, 250 Williams Street, Atlanta, GA 30303-1002, USA. marji.mccullough@cancer.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

18187388

Citation

McCullough, Marjorie L., et al. "Body Mass and Endometrial Cancer Risk By Hormone Replacement Therapy and Cancer Subtype." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 1, 2008, pp. 73-9.
McCullough ML, Patel AV, Patel R, et al. Body mass and endometrial cancer risk by hormone replacement therapy and cancer subtype. Cancer Epidemiol Biomarkers Prev. 2008;17(1):73-9.
McCullough, M. L., Patel, A. V., Patel, R., Rodriguez, C., Feigelson, H. S., Bandera, E. V., Gansler, T., Thun, M. J., & Calle, E. E. (2008). Body mass and endometrial cancer risk by hormone replacement therapy and cancer subtype. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(1), 73-9. https://doi.org/10.1158/1055-9965.EPI-07-2567
McCullough ML, et al. Body Mass and Endometrial Cancer Risk By Hormone Replacement Therapy and Cancer Subtype. Cancer Epidemiol Biomarkers Prev. 2008;17(1):73-9. PubMed PMID: 18187388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass and endometrial cancer risk by hormone replacement therapy and cancer subtype. AU - McCullough,Marjorie L, AU - Patel,Alpa V, AU - Patel,Roshni, AU - Rodriguez,Carmen, AU - Feigelson,Heather Spencer, AU - Bandera,Elisa V, AU - Gansler,Ted, AU - Thun,Michael J, AU - Calle,Eugenia E, Y1 - 2008/01/09/ PY - 2008/1/12/pubmed PY - 2008/4/2/medline PY - 2008/1/12/entrez SP - 73 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 1 N2 - Epidemiologic studies unequivocally show that greater body mass increases the risk of endometrial cancer, but whether risk varies by use of postmenopausal hormone therapy (HT), location of fat deposition, or cancer subtype is still unclear. We examined these associations among 33,436 postmenopausal women in the Cancer Prevention Study II Nutrition Cohort, who completed questionnaires on diet, lifestyle, and medical history at baseline in 1992. A total of 318 cases were eligible through June 2003. Cox-proportional hazards analyses were used to estimate multivariate-adjusted rate ratios (RR). As expected, adult body mass index (BMI) was a strong predictor of risk [RR, 4.70; 95% confidence interval (CI), 3.12-7.07 for BMI 35+ versus 22.5-25.0, P trend < 0.0001]. Use of estrogen plus progestin postmenopausal HT modified the association. Among never-users, risk was significantly linear across the entire range of BMI examined (RR, 0.51; 95% CI, 0.29-0.92 for <22.5 versus 22.5-25.0; RR, 4.41; 95% CI, 2.70-7.20 for > or =35 versus 22.5-25.0, P trend < 0.0001), but among ever estrogen plus progestin users, the association was not significant (P trend = 1.0; P interaction < 0.0001). We observed no difference in risk according to tendency for central versus peripheral fat deposition. Greater BMI (> or =30 versus <25.0) increased risk of both "type I" (classic estrogen pathway, RR, 4.22; 95% CI, 3.07-5.81) and "type II" (serous, clear cell, and all other high grade) cancers (RR, 2.87; 95% CI, 1.59-5.16). The increased risk of endometrial cancer across the range of BMI in women who never used postmenopausal HT stresses the need to prevent both overweight and obesity in women. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18187388/Body_mass_and_endometrial_cancer_risk_by_hormone_replacement_therapy_and_cancer_subtype_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=18187388 DB - PRIME DP - Unbound Medicine ER -