Tags

Type your tag names separated by a space and hit enter

Overweight and obesity at different times in life as risk factors for non-Hodgkin's lymphoma: the multiethnic cohort.
Cancer Epidemiol Biomarkers Prev. 2008 Jan; 17(1):196-203.CE

Abstract

Obesity may increase the risk for non-Hodgkin's lymphoma (NHL) through an inflammatory pathway. We explored the relation of NHL with body size at different times in life within the Multiethnic Cohort that includes African Americans, Caucasians, Japanese, Latinos, and Native Hawaiians. Participants were 45 to 75 years old at recruitment in 1993 to 1996. This analysis included 87,079 men and 105,972 women with 461 male and 378 female NHL cases. We used Cox regression to model NHL risk with age as the time metric while adjusting for age at baseline, ethnicity, education, alcohol intake, and age at first live birth. Body weight and body mass index at age 21 were stronger predictors of NHL risk than anthropometric characteristics at baseline. For men, being in the highest quartile of body mass index and body weight at age 21 conferred a nonsignificant 86% and 41% higher NHL risk, respectively, whereas there was no association at baseline. For women, the risk associated with the highest quartile of weight at age 21 was 1.6 (P(trend) = 0.04), whereas women in the highest quartile at baseline had a nonsignificant risk of 27%. Height was positively related to NHL in men and women. Despite the small numbers, there was some consistency for risk estimates across ethnic groups and weak evidence for an association with NHL subtypes. These findings indicate that weight at age 21 may represent lifetime adiposity better than body weight at cohort entry. Alternatively, weight at age 21 may be more relevant for the etiology of NHL.

Authors+Show Affiliations

Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA. gertraud@crch.hawaii.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18187389

Citation

Maskarinec, Gertraud, et al. "Overweight and Obesity at Different Times in Life as Risk Factors for non-Hodgkin's Lymphoma: the Multiethnic Cohort." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 1, 2008, pp. 196-203.
Maskarinec G, Erber E, Gill J, et al. Overweight and obesity at different times in life as risk factors for non-Hodgkin's lymphoma: the multiethnic cohort. Cancer Epidemiol Biomarkers Prev. 2008;17(1):196-203.
Maskarinec, G., Erber, E., Gill, J., Cozen, W., & Kolonel, L. N. (2008). Overweight and obesity at different times in life as risk factors for non-Hodgkin's lymphoma: the multiethnic cohort. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(1), 196-203. https://doi.org/10.1158/1055-9965.EPI-07-0716
Maskarinec G, et al. Overweight and Obesity at Different Times in Life as Risk Factors for non-Hodgkin's Lymphoma: the Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev. 2008;17(1):196-203. PubMed PMID: 18187389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overweight and obesity at different times in life as risk factors for non-Hodgkin's lymphoma: the multiethnic cohort. AU - Maskarinec,Gertraud, AU - Erber,Eva, AU - Gill,Jasmeet, AU - Cozen,Wendy, AU - Kolonel,Laurence N, Y1 - 2008/01/09/ PY - 2008/1/12/pubmed PY - 2008/4/2/medline PY - 2008/1/12/entrez SP - 196 EP - 203 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 1 N2 - Obesity may increase the risk for non-Hodgkin's lymphoma (NHL) through an inflammatory pathway. We explored the relation of NHL with body size at different times in life within the Multiethnic Cohort that includes African Americans, Caucasians, Japanese, Latinos, and Native Hawaiians. Participants were 45 to 75 years old at recruitment in 1993 to 1996. This analysis included 87,079 men and 105,972 women with 461 male and 378 female NHL cases. We used Cox regression to model NHL risk with age as the time metric while adjusting for age at baseline, ethnicity, education, alcohol intake, and age at first live birth. Body weight and body mass index at age 21 were stronger predictors of NHL risk than anthropometric characteristics at baseline. For men, being in the highest quartile of body mass index and body weight at age 21 conferred a nonsignificant 86% and 41% higher NHL risk, respectively, whereas there was no association at baseline. For women, the risk associated with the highest quartile of weight at age 21 was 1.6 (P(trend) = 0.04), whereas women in the highest quartile at baseline had a nonsignificant risk of 27%. Height was positively related to NHL in men and women. Despite the small numbers, there was some consistency for risk estimates across ethnic groups and weak evidence for an association with NHL subtypes. These findings indicate that weight at age 21 may represent lifetime adiposity better than body weight at cohort entry. Alternatively, weight at age 21 may be more relevant for the etiology of NHL. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18187389/Overweight_and_obesity_at_different_times_in_life_as_risk_factors_for_non_Hodgkin's_lymphoma:_the_multiethnic_cohort_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18187389 DB - PRIME DP - Unbound Medicine ER -