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Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa.
Eye (Lond). 2009 Feb; 23(2):304-8.E

Abstract

PURPOSE

To determine whether a significant correlation exists between the visual acuity or foveal thickness and the status of the inner and outer segment junction (IS/OS) of the photoreceptor in patients with retinitis pigmentosa (RP).

METHODS

Three hundred eyes of 163 patients with RP were examined with the optical coherence tomography (OCT). The IS/OS appeared as a distinct, highly reflective line just vitread of the retinal pigment epithelium in the OCT3 images. The IS/OS line was graded into three groups. The correlations between the grade of the IS/OS and age, best-corrected visual acuity (BCVA), and central foveal thickness (CFT) were determined.

RESULTS

Grade 1 included 93 eyes (31.0%) in which an IS/OS line was not seen, Grade 2 included 67 eyes (22.3%) with an abnormal IS/OS, and Grade 3 included 140 eyes (46.7%) with a normal IS/OS. The correlation between the IS/OS grade and age was not significant (P=0.5536). The IS/OS grade was significantly correlated with BCVA and CFT (both P<0.0001). The BCVA was significantly better in Grade 3 eyes than Grades 1 and 2 (both P<0.0001). The CFT was significantly thinner in Grade 1 eyes than in Grades 2 and 3 (both P<0.0001). In Grade 3, the mean length of the IS/OS was 2.51+/-1.42 mm (+/-SD). The length of the IS/OS was significantly correlated with the BCVA (P<0.0001, r=-0.375).

CONCLUSIONS

The presence of the IS/OS was associated with better visual acuity and thicker fovea in RP patients. The absence of an IS/OS may reflect a foveal dysfunction in RP patients.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Aizawa S
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Japan.
Mitamura Y
No affiliation info available
Baba T
No affiliation info available
Hagiwara A
No affiliation info available
Ogata K
No affiliation info available
Yamamoto S
No affiliation info available

MeSH

AdolescentAdultAgedChildCross-Sectional StudiesFemaleFovea CentralisHumansMaleMiddle AgedRetinal Photoreceptor Cell Inner SegmentRetinal Photoreceptor Cell Outer SegmentRetinitis PigmentosaSeverity of Illness IndexTomography, Optical CoherenceVisual AcuityYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18188175

Citation

Aizawa, S, et al. "Correlation Between Visual Function and Photoreceptor Inner/outer Segment Junction in Patients With Retinitis Pigmentosa." Eye (London, England), vol. 23, no. 2, 2009, pp. 304-8.
Aizawa S, Mitamura Y, Baba T, et al. Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa. Eye (Lond). 2009;23(2):304-8.
Aizawa, S., Mitamura, Y., Baba, T., Hagiwara, A., Ogata, K., & Yamamoto, S. (2009). Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa. Eye (London, England), 23(2), 304-8. https://doi.org/10.1038/sj.eye.6703076
Aizawa S, et al. Correlation Between Visual Function and Photoreceptor Inner/outer Segment Junction in Patients With Retinitis Pigmentosa. Eye (Lond). 2009;23(2):304-8. PubMed PMID: 18188175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa. AU - Aizawa,S, AU - Mitamura,Y, AU - Baba,T, AU - Hagiwara,A, AU - Ogata,K, AU - Yamamoto,S, Y1 - 2008/01/11/ PY - 2008/1/12/pubmed PY - 2010/1/8/medline PY - 2008/1/12/entrez SP - 304 EP - 8 JF - Eye (London, England) JO - Eye (Lond) VL - 23 IS - 2 N2 - PURPOSE: To determine whether a significant correlation exists between the visual acuity or foveal thickness and the status of the inner and outer segment junction (IS/OS) of the photoreceptor in patients with retinitis pigmentosa (RP). METHODS: Three hundred eyes of 163 patients with RP were examined with the optical coherence tomography (OCT). The IS/OS appeared as a distinct, highly reflective line just vitread of the retinal pigment epithelium in the OCT3 images. The IS/OS line was graded into three groups. The correlations between the grade of the IS/OS and age, best-corrected visual acuity (BCVA), and central foveal thickness (CFT) were determined. RESULTS: Grade 1 included 93 eyes (31.0%) in which an IS/OS line was not seen, Grade 2 included 67 eyes (22.3%) with an abnormal IS/OS, and Grade 3 included 140 eyes (46.7%) with a normal IS/OS. The correlation between the IS/OS grade and age was not significant (P=0.5536). The IS/OS grade was significantly correlated with BCVA and CFT (both P<0.0001). The BCVA was significantly better in Grade 3 eyes than Grades 1 and 2 (both P<0.0001). The CFT was significantly thinner in Grade 1 eyes than in Grades 2 and 3 (both P<0.0001). In Grade 3, the mean length of the IS/OS was 2.51+/-1.42 mm (+/-SD). The length of the IS/OS was significantly correlated with the BCVA (P<0.0001, r=-0.375). CONCLUSIONS: The presence of the IS/OS was associated with better visual acuity and thicker fovea in RP patients. The absence of an IS/OS may reflect a foveal dysfunction in RP patients. SN - 1476-5454 UR - https://www.unboundmedicine.com/medline/citation/18188175/Correlation_between_visual_function_and_photoreceptor_inner/outer_segment_junction_in_patients_with_retinitis_pigmentosa_ DB - PRIME DP - Unbound Medicine ER -