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Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study.
Int J Geriatr Psychiatry. 2008 Jul; 23(7):741-7.IJ

Abstract

OBJECTIVE

To investigate the association of midlife dietary fat intake to cognitive performance, and to the occurrence of clinical mild cognitive impairment (MCI) later in life in a non-demented population.

DESIGN

A longitudinal population-based study.

SETTING

Populations of Kuopio and Joensuu, Eastern Finland.

PARTICIPANTS AND METHODS

Participants of the CAIDE study were derived from random, population-based samples studied at midlife (1972, 1977, 1982 or 1987). After an average follow-up of 21 years, a total of 1449 (72%) individuals aged 65-80 years participated in the re-examination in 1998. Altogether 82 (5.7%) people were diagnosed as having MCI. Dietary information was collected with a structured questionnaire and an interview at midlife.

MAIN OUTCOME MEASURES

MCI, global cognitive and executive functions, episodic, semantic and prospective memory and psychomotor speed.

RESULTS

Abundant saturated fat (SFA) intake from milk products and spreads at midlife was associated with poorer global cognitive function and prospective memory and with an increased risk of MCI (OR 2.36, 95% CI 1.17-4.74) after adjusting for demographic and vascular factors, other fats and ApoE. On the contrary, high intake of polyunsaturated fatty acids (PUFA) was associated with better semantic memory. Also frequent fish consumption was associated with better global cognitive function and semantic memory. Further, higher PUFA-SFA ratio was associated with better psychomotor speed and executive function.

CONCLUSIONS

Our data suggests that dietary fat intake at midlife affects cognitive performance and occurrence of MCI later in life. The impact of dietary interventions needs to be tested in clinical trials.

Authors+Show Affiliations

Department of Neurology, University of Kuopio, Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18188871

Citation

Eskelinen, Marjo H., et al. "Fat Intake at Midlife and Cognitive Impairment Later in Life: a Population-based CAIDE Study." International Journal of Geriatric Psychiatry, vol. 23, no. 7, 2008, pp. 741-7.
Eskelinen MH, Ngandu T, Helkala EL, et al. Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study. Int J Geriatr Psychiatry. 2008;23(7):741-7.
Eskelinen, M. H., Ngandu, T., Helkala, E. L., Tuomilehto, J., Nissinen, A., Soininen, H., & Kivipelto, M. (2008). Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study. International Journal of Geriatric Psychiatry, 23(7), 741-7. https://doi.org/10.1002/gps.1969
Eskelinen MH, et al. Fat Intake at Midlife and Cognitive Impairment Later in Life: a Population-based CAIDE Study. Int J Geriatr Psychiatry. 2008;23(7):741-7. PubMed PMID: 18188871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study. AU - Eskelinen,Marjo H, AU - Ngandu,Tiia, AU - Helkala,Eeva-Liisa, AU - Tuomilehto,Jaakko, AU - Nissinen,Aulikki, AU - Soininen,Hilkka, AU - Kivipelto,Miia, PY - 2008/1/12/pubmed PY - 2008/12/30/medline PY - 2008/1/12/entrez SP - 741 EP - 7 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 23 IS - 7 N2 - OBJECTIVE: To investigate the association of midlife dietary fat intake to cognitive performance, and to the occurrence of clinical mild cognitive impairment (MCI) later in life in a non-demented population. DESIGN: A longitudinal population-based study. SETTING: Populations of Kuopio and Joensuu, Eastern Finland. PARTICIPANTS AND METHODS: Participants of the CAIDE study were derived from random, population-based samples studied at midlife (1972, 1977, 1982 or 1987). After an average follow-up of 21 years, a total of 1449 (72%) individuals aged 65-80 years participated in the re-examination in 1998. Altogether 82 (5.7%) people were diagnosed as having MCI. Dietary information was collected with a structured questionnaire and an interview at midlife. MAIN OUTCOME MEASURES: MCI, global cognitive and executive functions, episodic, semantic and prospective memory and psychomotor speed. RESULTS: Abundant saturated fat (SFA) intake from milk products and spreads at midlife was associated with poorer global cognitive function and prospective memory and with an increased risk of MCI (OR 2.36, 95% CI 1.17-4.74) after adjusting for demographic and vascular factors, other fats and ApoE. On the contrary, high intake of polyunsaturated fatty acids (PUFA) was associated with better semantic memory. Also frequent fish consumption was associated with better global cognitive function and semantic memory. Further, higher PUFA-SFA ratio was associated with better psychomotor speed and executive function. CONCLUSIONS: Our data suggests that dietary fat intake at midlife affects cognitive performance and occurrence of MCI later in life. The impact of dietary interventions needs to be tested in clinical trials. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/18188871/Fat_intake_at_midlife_and_cognitive_impairment_later_in_life:_a_population_based_CAIDE_study_ L2 - https://doi.org/10.1002/gps.1969 DB - PRIME DP - Unbound Medicine ER -