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Current concepts in bone and reproductive health in adolescents with anorexia nervosa.
BJOG 2008; 115(3):304-15BJOG

Abstract

Anorexia nervosa (AN) initiates an adaptive response at the level of the hypothalamus, which results in a complex interplay involving most elements of the neuroendocrine axis. Consequences of onset of disease in adolescence include amenorrhoea, pubertal arrest with potential loss of target height, and osteoporosis with reduced capacity for future attainment of peak bone mass. With recovery, delay in restoration of menses is common. Hormonal therapies for restoration of bone mineral density (BMD) in adolescents have shown limited efficacy. This review will discuss the reproductive endocrine effects of AN in adolescence, and discuss new investigative tools for monitoring restoration of reproductive function and BMD in this population.

Authors+Show Affiliations

Department of Gynaecology Royal Children's Hospital, Melbourne, Victoria, Australia. yasmin.jayasinghe@rch.org.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18190366

Citation

Jayasinghe, Y, et al. "Current Concepts in Bone and Reproductive Health in Adolescents With Anorexia Nervosa." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 115, no. 3, 2008, pp. 304-15.
Jayasinghe Y, Grover SR, Zacharin M. Current concepts in bone and reproductive health in adolescents with anorexia nervosa. BJOG. 2008;115(3):304-15.
Jayasinghe, Y., Grover, S. R., & Zacharin, M. (2008). Current concepts in bone and reproductive health in adolescents with anorexia nervosa. BJOG : an International Journal of Obstetrics and Gynaecology, 115(3), pp. 304-15. doi:10.1111/j.1471-0528.2007.01601.x.
Jayasinghe Y, Grover SR, Zacharin M. Current Concepts in Bone and Reproductive Health in Adolescents With Anorexia Nervosa. BJOG. 2008;115(3):304-15. PubMed PMID: 18190366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current concepts in bone and reproductive health in adolescents with anorexia nervosa. AU - Jayasinghe,Y, AU - Grover,S R, AU - Zacharin,M, PY - 2008/1/15/pubmed PY - 2008/2/8/medline PY - 2008/1/15/entrez SP - 304 EP - 15 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 115 IS - 3 N2 - Anorexia nervosa (AN) initiates an adaptive response at the level of the hypothalamus, which results in a complex interplay involving most elements of the neuroendocrine axis. Consequences of onset of disease in adolescence include amenorrhoea, pubertal arrest with potential loss of target height, and osteoporosis with reduced capacity for future attainment of peak bone mass. With recovery, delay in restoration of menses is common. Hormonal therapies for restoration of bone mineral density (BMD) in adolescents have shown limited efficacy. This review will discuss the reproductive endocrine effects of AN in adolescence, and discuss new investigative tools for monitoring restoration of reproductive function and BMD in this population. SN - 1471-0528 UR - https://www.unboundmedicine.com/medline/citation/18190366/Current_concepts_in_bone_and_reproductive_health_in_adolescents_with_anorexia_nervosa_ L2 - https://doi.org/10.1111/j.1471-0528.2007.01601.x DB - PRIME DP - Unbound Medicine ER -