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Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men.
Metabolism. 2008 Feb; 57(2):299-303.M

Abstract

To evaluate the factors associated with age-related increase in fasting plasma glucose (FPG) in Japanese men with normal fasting glucose, we measured FPG, fasting immunoreactive insulin, glycated hemoglobin, total cholesterol, triglyceride, and high-density lipoprotein cholesterol levels in health check examinees. Subjects with FPG less than 6.1 mmol/L together with glycated hemoglobin less than 5.6% were enrolled in the study. The homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA-beta were used as the indices of insulin sensitivity and insulin secretion, respectively. Fasting plasma glucose increased significantly with age (r = 0.30, P < .0001), and HOMA-beta decreased significantly with age (r = 0.24, P < .0001). The HOMA-IR had no significant relation with age (r = 0.06, not significant), whereas body mass index and serum triglyceride were associated with HOMA-IR (r = 0.49, P < .0001 and r = 0.33, P < .0001, respectively). Thus, in Japanese male subjects with normal fasting glucose, it is suggested that the FPG increment with age is associated with decreased beta-cell function rather than with insulin resistance. Further analyses were performed by comparing 3 groups: low FPG (FPG <5.0 mmol/L), high FPG (5.0 < or = FPG < 5.6 mmol/L), and mild impairment of fasting glycemia (mild IFG) (5.6 < or = FPG < 6.1 mmol/L). The insulin levels in mild IFG and high FPG were significantly higher than in low FPG (P < .001), but those in mild IFG were similar to those in high FPG. Analysis of the 3 subgroups revealed that, whereas insulin sensitivity was impaired more in high FPG, there was little compensatory increase in insulin in mild IFG, suggesting that beta-cell function is already deteriorated when the FPG level is greater than 5.6 mmol/L.

Authors+Show Affiliations

Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18191064

Citation

Toyoda, Kentaro, et al. "Factors Responsible for Age-related Elevation in Fasting Plasma Glucose: a Cross-sectional Study in Japanese Men." Metabolism: Clinical and Experimental, vol. 57, no. 2, 2008, pp. 299-303.
Toyoda K, Fukushima M, Mitsui R, et al. Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men. Metabolism. 2008;57(2):299-303.
Toyoda, K., Fukushima, M., Mitsui, R., Harada, N., Suzuki, H., Takeda, T., Taniguchi, A., Nakai, Y., Kawakita, T., Yamada, Y., Inagaki, N., & Seino, Y. (2008). Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men. Metabolism: Clinical and Experimental, 57(2), 299-303. https://doi.org/10.1016/j.metabol.2007.10.002
Toyoda K, et al. Factors Responsible for Age-related Elevation in Fasting Plasma Glucose: a Cross-sectional Study in Japanese Men. Metabolism. 2008;57(2):299-303. PubMed PMID: 18191064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men. AU - Toyoda,Kentaro, AU - Fukushima,Mitsuo, AU - Mitsui,Rie, AU - Harada,Norio, AU - Suzuki,Hidehiko, AU - Takeda,Tomomi, AU - Taniguchi,Ataru, AU - Nakai,Yoshikatsu, AU - Kawakita,Toshiko, AU - Yamada,Yuichiro, AU - Inagaki,Nobuya, AU - Seino,Yutaka, PY - 2006/02/14/received PY - 2007/10/15/accepted PY - 2008/1/15/pubmed PY - 2008/3/26/medline PY - 2008/1/15/entrez SP - 299 EP - 303 JF - Metabolism: clinical and experimental JO - Metabolism VL - 57 IS - 2 N2 - To evaluate the factors associated with age-related increase in fasting plasma glucose (FPG) in Japanese men with normal fasting glucose, we measured FPG, fasting immunoreactive insulin, glycated hemoglobin, total cholesterol, triglyceride, and high-density lipoprotein cholesterol levels in health check examinees. Subjects with FPG less than 6.1 mmol/L together with glycated hemoglobin less than 5.6% were enrolled in the study. The homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA-beta were used as the indices of insulin sensitivity and insulin secretion, respectively. Fasting plasma glucose increased significantly with age (r = 0.30, P < .0001), and HOMA-beta decreased significantly with age (r = 0.24, P < .0001). The HOMA-IR had no significant relation with age (r = 0.06, not significant), whereas body mass index and serum triglyceride were associated with HOMA-IR (r = 0.49, P < .0001 and r = 0.33, P < .0001, respectively). Thus, in Japanese male subjects with normal fasting glucose, it is suggested that the FPG increment with age is associated with decreased beta-cell function rather than with insulin resistance. Further analyses were performed by comparing 3 groups: low FPG (FPG <5.0 mmol/L), high FPG (5.0 < or = FPG < 5.6 mmol/L), and mild impairment of fasting glycemia (mild IFG) (5.6 < or = FPG < 6.1 mmol/L). The insulin levels in mild IFG and high FPG were significantly higher than in low FPG (P < .001), but those in mild IFG were similar to those in high FPG. Analysis of the 3 subgroups revealed that, whereas insulin sensitivity was impaired more in high FPG, there was little compensatory increase in insulin in mild IFG, suggesting that beta-cell function is already deteriorated when the FPG level is greater than 5.6 mmol/L. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/18191064/Factors_responsible_for_age_related_elevation_in_fasting_plasma_glucose:_a_cross_sectional_study_in_Japanese_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(07)00356-3 DB - PRIME DP - Unbound Medicine ER -