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Prediction of 10-year coronary heart disease risk in Caribbean type 2 diabetic patients using the UKPDS risk engine.
Int J Cardiol. 2009 Mar 06; 132(3):348-53.IJ

Abstract

OBJECTIVE

Primary prevention of Coronary Heart Disease (CHD) in diabetic patients should be based on absolute CHD risk calculation. This study was aimed to determine the levels of 10-year CHD risk in Caribbean type 2 diabetic patients using the diabetes specific United Kingdom Prospective Diabetes Study (UKPDS) risk engine calculator.

SUBJECTS AND METHODS

Three hundred and twenty-five (106 males, 219 females) type 2 diabetic patients resident in two Caribbean Islands of Tobago and Trinidad met the UKPDS risk engine inclusion criteria. Records of their sex, age, ethnicity, smoking habit, diabetes duration, systolic blood pressure, total cholesterol, HDL-cholesterol and glycated haemoglobin were entered into the UKPDS risk engine calculator programme and the absolute 10-year CHD and stroke risk levels were computed. The 10-year CHD and stroke risks were statistically stratified into <15%, 15-30% and >30% CHD risk levels and differences between patients of African and Asian-Indian origin were compared.

RESULTS

In comparison with patients in Tobago, type 2 diabetic patients in Trinidad, irrespective of gender, had higher proportion of 10-year CHD risk (10.4 vs. 23.6%, P<0.001) whereas the overall 10-year stroke risk prediction was higher in patients resident in Tobago (16.9 vs. 11.4%, P<0.001). Ethnicity-based analysis revealed that irrespective of gender, higher proportion of patients of Indian origin scored >30% of absolute 10-year CHD risk compared with patients of African descent (3.2 vs. 28.2%, P<0.001).

CONCLUSIONS

The results of the study identified diabetic patients resident in Trinidad and patients of Indian origin as the most vulnerable groups for CHD. These groups of diabetic patients should have priority in primary or secondary prevention of coronary heart disease.

Authors+Show Affiliations

Unit of Pathology & Microbiology, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad, Trinidad and Tobago. cezenwaka@fms.uwi.ttNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18191239

Citation

Ezenwaka, C E., et al. "Prediction of 10-year Coronary Heart Disease Risk in Caribbean Type 2 Diabetic Patients Using the UKPDS Risk Engine." International Journal of Cardiology, vol. 132, no. 3, 2009, pp. 348-53.
Ezenwaka CE, Nwagbara E, Seales D, et al. Prediction of 10-year coronary heart disease risk in Caribbean type 2 diabetic patients using the UKPDS risk engine. Int J Cardiol. 2009;132(3):348-53.
Ezenwaka, C. E., Nwagbara, E., Seales, D., Okali, F., Hussaini, S., Raja, B., Jones-LeCointe, A., Sell, H., Avci, H., & Eckel, J. (2009). Prediction of 10-year coronary heart disease risk in Caribbean type 2 diabetic patients using the UKPDS risk engine. International Journal of Cardiology, 132(3), 348-53. https://doi.org/10.1016/j.ijcard.2007.12.005
Ezenwaka CE, et al. Prediction of 10-year Coronary Heart Disease Risk in Caribbean Type 2 Diabetic Patients Using the UKPDS Risk Engine. Int J Cardiol. 2009 Mar 6;132(3):348-53. PubMed PMID: 18191239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prediction of 10-year coronary heart disease risk in Caribbean type 2 diabetic patients using the UKPDS risk engine. AU - Ezenwaka,C E, AU - Nwagbara,E, AU - Seales,D, AU - Okali,F, AU - Hussaini,S, AU - Raja,Bn, AU - Jones-LeCointe,A, AU - Sell,H, AU - Avci,H, AU - Eckel,J, Y1 - 2008/01/11/ PY - 2007/03/29/received PY - 2007/08/29/revised PY - 2007/12/11/accepted PY - 2008/1/15/pubmed PY - 2009/7/16/medline PY - 2008/1/15/entrez SP - 348 EP - 53 JF - International journal of cardiology JO - Int J Cardiol VL - 132 IS - 3 N2 - OBJECTIVE: Primary prevention of Coronary Heart Disease (CHD) in diabetic patients should be based on absolute CHD risk calculation. This study was aimed to determine the levels of 10-year CHD risk in Caribbean type 2 diabetic patients using the diabetes specific United Kingdom Prospective Diabetes Study (UKPDS) risk engine calculator. SUBJECTS AND METHODS: Three hundred and twenty-five (106 males, 219 females) type 2 diabetic patients resident in two Caribbean Islands of Tobago and Trinidad met the UKPDS risk engine inclusion criteria. Records of their sex, age, ethnicity, smoking habit, diabetes duration, systolic blood pressure, total cholesterol, HDL-cholesterol and glycated haemoglobin were entered into the UKPDS risk engine calculator programme and the absolute 10-year CHD and stroke risk levels were computed. The 10-year CHD and stroke risks were statistically stratified into <15%, 15-30% and >30% CHD risk levels and differences between patients of African and Asian-Indian origin were compared. RESULTS: In comparison with patients in Tobago, type 2 diabetic patients in Trinidad, irrespective of gender, had higher proportion of 10-year CHD risk (10.4 vs. 23.6%, P<0.001) whereas the overall 10-year stroke risk prediction was higher in patients resident in Tobago (16.9 vs. 11.4%, P<0.001). Ethnicity-based analysis revealed that irrespective of gender, higher proportion of patients of Indian origin scored >30% of absolute 10-year CHD risk compared with patients of African descent (3.2 vs. 28.2%, P<0.001). CONCLUSIONS: The results of the study identified diabetic patients resident in Trinidad and patients of Indian origin as the most vulnerable groups for CHD. These groups of diabetic patients should have priority in primary or secondary prevention of coronary heart disease. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/18191239/Prediction_of_10_year_coronary_heart_disease_risk_in_Caribbean_type_2_diabetic_patients_using_the_UKPDS_risk_engine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(07)02139-0 DB - PRIME DP - Unbound Medicine ER -