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NMDA receptors are involved in Ginkgo extract-induced facilitation on memory retention of passive avoidance learning in rats.
Neurosci Lett. 2008 Feb 27; 432(3):206-11.NL

Abstract

Herbal therapies are commonly used to enhance memory and learning. Ginkgo biloba has shown to be one of the most popular herbs that is used to treat amnesia and retard age related memory deficits. Although, there have been several reports on the memory enhancing effects of Ginkgo, involvement of glutamatergic system that plays pivotal role in learning and memory has not been precisely assessed so far. The current study intended to investigate the effect of Ginkgo intake on amnesia while NMDA (N-methyl D-aspartic acid) receptors blocked by the administration of MK-801. The study used passive avoidance (PA) task to investigate the effect of chronic administration of Ginkgo extract (40 and 90 mg/kg; oral) on the memory span in male Wistar rats, suffering from MK-801-induced forgetfulness (0.06 and 0.1 mg/kg; i.p.). The results indicate that Ginkgo was able to remove MK-801-induced forgetfulness, indicating that Ginkgo can affect memory retention but not effect on passive avoidance acquisition, using pathways other than glutamatergic system as well. The results might indicate that Ginkgo extract can be effective in removing forgetfulness caused by inhibiting NMDA receptors from performing their activities.

Authors+Show Affiliations

Neuroscience Research Center, Shaheed Beheshti Medical University, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18191327

Citation

Nooshinfar, Elaheh, et al. "NMDA Receptors Are Involved in Ginkgo Extract-induced Facilitation On Memory Retention of Passive Avoidance Learning in Rats." Neuroscience Letters, vol. 432, no. 3, 2008, pp. 206-11.
Nooshinfar E, Lashgari R, Haghparast A, et al. NMDA receptors are involved in Ginkgo extract-induced facilitation on memory retention of passive avoidance learning in rats. Neurosci Lett. 2008;432(3):206-11.
Nooshinfar, E., Lashgari, R., Haghparast, A., & Sajjadi, S. (2008). NMDA receptors are involved in Ginkgo extract-induced facilitation on memory retention of passive avoidance learning in rats. Neuroscience Letters, 432(3), 206-11. https://doi.org/10.1016/j.neulet.2007.12.022
Nooshinfar E, et al. NMDA Receptors Are Involved in Ginkgo Extract-induced Facilitation On Memory Retention of Passive Avoidance Learning in Rats. Neurosci Lett. 2008 Feb 27;432(3):206-11. PubMed PMID: 18191327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NMDA receptors are involved in Ginkgo extract-induced facilitation on memory retention of passive avoidance learning in rats. AU - Nooshinfar,Elaheh, AU - Lashgari,Reza, AU - Haghparast,Abbas, AU - Sajjadi,Samand, Y1 - 2007/12/23/ PY - 2007/05/11/received PY - 2007/11/25/revised PY - 2007/12/05/accepted PY - 2008/1/15/pubmed PY - 2008/6/13/medline PY - 2008/1/15/entrez SP - 206 EP - 11 JF - Neuroscience letters JO - Neurosci Lett VL - 432 IS - 3 N2 - Herbal therapies are commonly used to enhance memory and learning. Ginkgo biloba has shown to be one of the most popular herbs that is used to treat amnesia and retard age related memory deficits. Although, there have been several reports on the memory enhancing effects of Ginkgo, involvement of glutamatergic system that plays pivotal role in learning and memory has not been precisely assessed so far. The current study intended to investigate the effect of Ginkgo intake on amnesia while NMDA (N-methyl D-aspartic acid) receptors blocked by the administration of MK-801. The study used passive avoidance (PA) task to investigate the effect of chronic administration of Ginkgo extract (40 and 90 mg/kg; oral) on the memory span in male Wistar rats, suffering from MK-801-induced forgetfulness (0.06 and 0.1 mg/kg; i.p.). The results indicate that Ginkgo was able to remove MK-801-induced forgetfulness, indicating that Ginkgo can affect memory retention but not effect on passive avoidance acquisition, using pathways other than glutamatergic system as well. The results might indicate that Ginkgo extract can be effective in removing forgetfulness caused by inhibiting NMDA receptors from performing their activities. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/18191327/NMDA_receptors_are_involved_in_Ginkgo_extract_induced_facilitation_on_memory_retention_of_passive_avoidance_learning_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(07)01295-5 DB - PRIME DP - Unbound Medicine ER -