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Hypolipidaemic activity of Helicteres isora L. bark extracts in streptozotocin induced diabetic rats.
J Ethnopharmacol. 2008 Feb 28; 116(1):161-6.JE

Abstract

In this study, the hypolipidaemic effect of an aqueous extract of the bark of Helicteres isora was investigated in streptozotocin (STZ)-induced diabetic rats. Administration of the bark extract of Helicteres isora (100 and 200 mg/kgb.w.) for 21 days resulted in significant reduction in serum and tissue cholesterol, phospholipids, free fatty acids and triglycerides in STZ diabetic rats. In addition to that, significant (p<0.05) decrease in high-density lipoprotein (HDL) whereas significant increase (p<0.05) low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were observed in STZ diabetic rats, which were normalized after 21 days of bark extract treatment. The bark extract at a dose of 200 mg/kgb.w. showed much significant hypolipidaemic effect than at the dose of 100 mg/kgb.w.

Authors+Show Affiliations

Division of Industrial Toxicology and Pollution Control, Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, Tamilnadu 627412, India. pgsvedhakumar@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18191354

Citation

Kumar, G, and A G. Murugesan. "Hypolipidaemic Activity of Helicteres Isora L. Bark Extracts in Streptozotocin Induced Diabetic Rats." Journal of Ethnopharmacology, vol. 116, no. 1, 2008, pp. 161-6.
Kumar G, Murugesan AG. Hypolipidaemic activity of Helicteres isora L. bark extracts in streptozotocin induced diabetic rats. J Ethnopharmacol. 2008;116(1):161-6.
Kumar, G., & Murugesan, A. G. (2008). Hypolipidaemic activity of Helicteres isora L. bark extracts in streptozotocin induced diabetic rats. Journal of Ethnopharmacology, 116(1), 161-6. https://doi.org/10.1016/j.jep.2007.11.020
Kumar G, Murugesan AG. Hypolipidaemic Activity of Helicteres Isora L. Bark Extracts in Streptozotocin Induced Diabetic Rats. J Ethnopharmacol. 2008 Feb 28;116(1):161-6. PubMed PMID: 18191354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypolipidaemic activity of Helicteres isora L. bark extracts in streptozotocin induced diabetic rats. AU - Kumar,G, AU - Murugesan,A G, Y1 - 2007/11/22/ PY - 2006/05/10/received PY - 2007/10/26/revised PY - 2007/11/15/accepted PY - 2008/1/15/pubmed PY - 2008/5/2/medline PY - 2008/1/15/entrez SP - 161 EP - 6 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 116 IS - 1 N2 - In this study, the hypolipidaemic effect of an aqueous extract of the bark of Helicteres isora was investigated in streptozotocin (STZ)-induced diabetic rats. Administration of the bark extract of Helicteres isora (100 and 200 mg/kgb.w.) for 21 days resulted in significant reduction in serum and tissue cholesterol, phospholipids, free fatty acids and triglycerides in STZ diabetic rats. In addition to that, significant (p<0.05) decrease in high-density lipoprotein (HDL) whereas significant increase (p<0.05) low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were observed in STZ diabetic rats, which were normalized after 21 days of bark extract treatment. The bark extract at a dose of 200 mg/kgb.w. showed much significant hypolipidaemic effect than at the dose of 100 mg/kgb.w. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18191354/Hypolipidaemic_activity_of_Helicteres_isora_L__bark_extracts_in_streptozotocin_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00615-0 DB - PRIME DP - Unbound Medicine ER -