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Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: a voxel-based morphometry study.
J Affect Disord. 2008 Jul; 109(1-2):107-16.JA

Abstract

BACKGROUND

Functional neuroimaging studies on both cognitive processing and psychopathology in patients with major depression have reported several functionally aberrant brain areas within limbic-cortical circuits. However, less is known about the relationship between psychopathology, cognitive deficits and regional volume alterations in this patient population.

METHODS

By means of voxel-based morphometry (VBM) and a standardized neuropsychological test battery, we examined 15 patients meeting DSM-IV criteria for major depression disorder and 14 healthy controls in order to investigate the relationship between affective symptoms, cognitive deficits and structural abnormalities.

RESULTS

Patients with depression showed reduced gray matter concentration (GMC) in the left inferior temporal cortex (BA 20), the right orbitofrontal (BA 11) and the dorsolateral prefrontal cortex (BA 46). Reduced gray matter volume (GMV) was found in the left hippocampal gyrus, the cingulate gyrus (BA 24/32) and the thalamus. Structure-cognition correlation analyses revealed that decreased GMC of the right medial and inferior frontal gyrus was associated with both depressive psychopathology and worse executive performance as measured by the Wisconsin Card Sorting Test (WCST). Furthermore, depressive psychopathology and worse performance during the WCST were associated with decreased GMV of the hippocampus. Decreased GMV of the cingulate cortex was associated with worse executive performance.

LIMITATIONS

Moderate illness severity, medication effects, and the relatively small patient sample size should be taken into consideration when reviewing the implications of these results.

CONCLUSIONS

The volumetric results indicate that regional abnormalities in gray matter volume and concentration may be associated with both psychopathological changes and cognitive deficits in depression.

Authors+Show Affiliations

Department of Psychiatry III, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany. nenad.vasic@uni-ulm.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18191459

Citation

Vasic, Nenad, et al. "Gray Matter Reduction Associated With Psychopathology and Cognitive Dysfunction in Unipolar Depression: a Voxel-based Morphometry Study." Journal of Affective Disorders, vol. 109, no. 1-2, 2008, pp. 107-16.
Vasic N, Walter H, Höse A, et al. Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: a voxel-based morphometry study. J Affect Disord. 2008;109(1-2):107-16.
Vasic, N., Walter, H., Höse, A., & Wolf, R. C. (2008). Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: a voxel-based morphometry study. Journal of Affective Disorders, 109(1-2), 107-16. https://doi.org/10.1016/j.jad.2007.11.011
Vasic N, et al. Gray Matter Reduction Associated With Psychopathology and Cognitive Dysfunction in Unipolar Depression: a Voxel-based Morphometry Study. J Affect Disord. 2008;109(1-2):107-16. PubMed PMID: 18191459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: a voxel-based morphometry study. AU - Vasic,Nenad, AU - Walter,Henrik, AU - Höse,Annett, AU - Wolf,Robert Christian, Y1 - 2008/01/09/ PY - 2007/07/15/received PY - 2007/11/26/revised PY - 2007/11/26/accepted PY - 2008/1/15/pubmed PY - 2008/9/27/medline PY - 2008/1/15/entrez SP - 107 EP - 16 JF - Journal of affective disorders JO - J Affect Disord VL - 109 IS - 1-2 N2 - BACKGROUND: Functional neuroimaging studies on both cognitive processing and psychopathology in patients with major depression have reported several functionally aberrant brain areas within limbic-cortical circuits. However, less is known about the relationship between psychopathology, cognitive deficits and regional volume alterations in this patient population. METHODS: By means of voxel-based morphometry (VBM) and a standardized neuropsychological test battery, we examined 15 patients meeting DSM-IV criteria for major depression disorder and 14 healthy controls in order to investigate the relationship between affective symptoms, cognitive deficits and structural abnormalities. RESULTS: Patients with depression showed reduced gray matter concentration (GMC) in the left inferior temporal cortex (BA 20), the right orbitofrontal (BA 11) and the dorsolateral prefrontal cortex (BA 46). Reduced gray matter volume (GMV) was found in the left hippocampal gyrus, the cingulate gyrus (BA 24/32) and the thalamus. Structure-cognition correlation analyses revealed that decreased GMC of the right medial and inferior frontal gyrus was associated with both depressive psychopathology and worse executive performance as measured by the Wisconsin Card Sorting Test (WCST). Furthermore, depressive psychopathology and worse performance during the WCST were associated with decreased GMV of the hippocampus. Decreased GMV of the cingulate cortex was associated with worse executive performance. LIMITATIONS: Moderate illness severity, medication effects, and the relatively small patient sample size should be taken into consideration when reviewing the implications of these results. CONCLUSIONS: The volumetric results indicate that regional abnormalities in gray matter volume and concentration may be associated with both psychopathological changes and cognitive deficits in depression. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/18191459/Gray_matter_reduction_associated_with_psychopathology_and_cognitive_dysfunction_in_unipolar_depression:_a_voxel_based_morphometry_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(07)00399-0 DB - PRIME DP - Unbound Medicine ER -