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Differential effects of acute alcohol on EEG and sedative responses in adolescent and adult Wistar rats.
Brain Res. 2008 Feb 15; 1194:28-36.BR

Abstract

Age-related developmental differences in sensitivity to the acute effects of alcohol may play an important role in the development of alcoholism. The present study was designed to evaluate the acute effects of alcohol on cortical electroencephalogram (EEG) in adolescent (P36) and adult (P78) Wistar rats. Five minutes of EEG was recorded after administration of 0, 0.75 or 1.5 g/kg alcohol. The righting reflex was performed to measure the sedative effects of alcohol (3.5 g/kg) and total sleeping time for each rat. Our results showed that alcohol (1.5 g/kg) increased power in the 1-2 Hz band and decreased the power in the 32-50 Hz band in the parietal cortical region of adolescent rats. Alcohol (1.5 g/kg) also increased stability of the EEG power in the slow-wave frequency bands (2-4 Hz, 4-6 Hz, and 6-8 Hz) of adolescent rats. In the frontal cortex of adult rats, but not in adolescent rats, alcohol (1.5 or 0.75 g/kg) decreased the power in the 16-32 Hz frequency band. Alcohol (1.5 g/kg) differentially increased power in a multiple of slow-wave frequency bands (2-4 Hz and 4-6 Hz) in the parietal cortex of adult rats as compared to adolescent rats. Adolescent rats were shown significantly shorter sleeping time and higher blood alcohol levels after regaining reflex than adult rats. Our results provide additional evidence of age-related differences in the effects of acute alcohol on cortical EEG, sedation and tolerance.

Authors+Show Affiliations

Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N. Torrey Pines Rd., SP30-1501, La Jolla, CA 92037, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18191821

Citation

Pian, Jerry P., et al. "Differential Effects of Acute Alcohol On EEG and Sedative Responses in Adolescent and Adult Wistar Rats." Brain Research, vol. 1194, 2008, pp. 28-36.
Pian JP, Criado JR, Walker BM, et al. Differential effects of acute alcohol on EEG and sedative responses in adolescent and adult Wistar rats. Brain Res. 2008;1194:28-36.
Pian, J. P., Criado, J. R., Walker, B. M., & Ehlers, C. L. (2008). Differential effects of acute alcohol on EEG and sedative responses in adolescent and adult Wistar rats. Brain Research, 1194, 28-36. https://doi.org/10.1016/j.brainres.2007.11.057
Pian JP, et al. Differential Effects of Acute Alcohol On EEG and Sedative Responses in Adolescent and Adult Wistar Rats. Brain Res. 2008 Feb 15;1194:28-36. PubMed PMID: 18191821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of acute alcohol on EEG and sedative responses in adolescent and adult Wistar rats. AU - Pian,Jerry P, AU - Criado,Jose R, AU - Walker,Brendan M, AU - Ehlers,Cindy L, Y1 - 2007/12/04/ PY - 2007/07/18/received PY - 2007/11/27/revised PY - 2007/11/29/accepted PY - 2008/1/15/pubmed PY - 2008/5/31/medline PY - 2008/1/15/entrez SP - 28 EP - 36 JF - Brain research JO - Brain Res. VL - 1194 N2 - Age-related developmental differences in sensitivity to the acute effects of alcohol may play an important role in the development of alcoholism. The present study was designed to evaluate the acute effects of alcohol on cortical electroencephalogram (EEG) in adolescent (P36) and adult (P78) Wistar rats. Five minutes of EEG was recorded after administration of 0, 0.75 or 1.5 g/kg alcohol. The righting reflex was performed to measure the sedative effects of alcohol (3.5 g/kg) and total sleeping time for each rat. Our results showed that alcohol (1.5 g/kg) increased power in the 1-2 Hz band and decreased the power in the 32-50 Hz band in the parietal cortical region of adolescent rats. Alcohol (1.5 g/kg) also increased stability of the EEG power in the slow-wave frequency bands (2-4 Hz, 4-6 Hz, and 6-8 Hz) of adolescent rats. In the frontal cortex of adult rats, but not in adolescent rats, alcohol (1.5 or 0.75 g/kg) decreased the power in the 16-32 Hz frequency band. Alcohol (1.5 g/kg) differentially increased power in a multiple of slow-wave frequency bands (2-4 Hz and 4-6 Hz) in the parietal cortex of adult rats as compared to adolescent rats. Adolescent rats were shown significantly shorter sleeping time and higher blood alcohol levels after regaining reflex than adult rats. Our results provide additional evidence of age-related differences in the effects of acute alcohol on cortical EEG, sedation and tolerance. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/18191821/Differential_effects_of_acute_alcohol_on_EEG_and_sedative_responses_in_adolescent_and_adult_Wistar_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(07)02866-1 DB - PRIME DP - Unbound Medicine ER -