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CSF Mg and Ca as diagnostic markers for dementia with Lewy bodies.

Abstract

Accumulating evidence implicates a role for altered metal homeostasis in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). However, few investigations have addressed this issue in dementia with Lewy bodies (DLB). The aim of the present study was to investigate metal concentrations in cerebrospinal fluid (CSF) and plasma from patients with DLB and other neurodegenerative disorders. To that end, CSF and plasma samples were collected from 29 patients with DLB, 174 patients with AD, 90 patients with AD with minor vascular components, and 51 healthy volunteers. Total concentrations of Mg, Ca, Mn, Fe, Cu, Zn, Rb, Sr, and Cs were determined using mass spectrometry. Patients with DLB had elevated Ca and Mg levels in CSF and Mg levels in plasma as compared to all other groups (p<0.001). Furthermore, a combination of CSF-Mg and CSF-Ca could distinguish DLB from AD with a sensitivity of 93% and a specificity of 85%. Cu levels in both CSF and plasma tended to be higher in DLB compared to the other groups, but these trends failed to reach significance after correction for multiple comparisons. Mn, Fe, Zn, Rb, and Sr concentration in CSF or plasma were similar in all groups. The observed elevations of CSF-Mg, CSF-Ca and CSF-Cu may contribute to or be associated with the neurodegenerative process in DLB. Furthermore, determination of CSF-Mg and CSF-Ca concentration may be a valuable tool in distinguishing DLB from AD.

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  • Authors+Show Affiliations

    ,

    Clinical Memory Research Unit, Department of Clinical Sciences, University Hospital MAS Malmö, Sweden. fredrik.bostrom@skane.se

    , , , , , ,

    Source

    Neurobiology of aging 30:8 2009 Aug pg 1265-71

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Analysis of Variance
    Biomarkers
    Calcium
    Cesium
    Copper
    Female
    Humans
    Iron
    Lewy Body Disease
    Magnesium
    Male
    Manganese
    Mass Spectrometry
    Middle Aged
    ROC Curve
    Rubidium
    Sensitivity and Specificity
    Strontium
    Zinc

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18191875

    Citation

    Boström, Fredrik, et al. "CSF Mg and Ca as Diagnostic Markers for Dementia With Lewy Bodies." Neurobiology of Aging, vol. 30, no. 8, 2009, pp. 1265-71.
    Boström F, Hansson O, Gerhardsson L, et al. CSF Mg and Ca as diagnostic markers for dementia with Lewy bodies. Neurobiol Aging. 2009;30(8):1265-71.
    Boström, F., Hansson, O., Gerhardsson, L., Lundh, T., Minthon, L., Stomrud, E., ... Londos, E. (2009). CSF Mg and Ca as diagnostic markers for dementia with Lewy bodies. Neurobiology of Aging, 30(8), pp. 1265-71. doi:10.1016/j.neurobiolaging.2007.10.018.
    Boström F, et al. CSF Mg and Ca as Diagnostic Markers for Dementia With Lewy Bodies. Neurobiol Aging. 2009;30(8):1265-71. PubMed PMID: 18191875.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - CSF Mg and Ca as diagnostic markers for dementia with Lewy bodies. AU - Boström,Fredrik, AU - Hansson,Oskar, AU - Gerhardsson,Lars, AU - Lundh,Thomas, AU - Minthon,Lennart, AU - Stomrud,Erik, AU - Zetterberg,Henrik, AU - Londos,Elisabet, Y1 - 2008/01/08/ PY - 2007/06/15/received PY - 2007/10/03/revised PY - 2007/10/29/accepted PY - 2008/1/15/pubmed PY - 2009/9/1/medline PY - 2008/1/15/entrez SP - 1265 EP - 71 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 30 IS - 8 N2 - Accumulating evidence implicates a role for altered metal homeostasis in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). However, few investigations have addressed this issue in dementia with Lewy bodies (DLB). The aim of the present study was to investigate metal concentrations in cerebrospinal fluid (CSF) and plasma from patients with DLB and other neurodegenerative disorders. To that end, CSF and plasma samples were collected from 29 patients with DLB, 174 patients with AD, 90 patients with AD with minor vascular components, and 51 healthy volunteers. Total concentrations of Mg, Ca, Mn, Fe, Cu, Zn, Rb, Sr, and Cs were determined using mass spectrometry. Patients with DLB had elevated Ca and Mg levels in CSF and Mg levels in plasma as compared to all other groups (p<0.001). Furthermore, a combination of CSF-Mg and CSF-Ca could distinguish DLB from AD with a sensitivity of 93% and a specificity of 85%. Cu levels in both CSF and plasma tended to be higher in DLB compared to the other groups, but these trends failed to reach significance after correction for multiple comparisons. Mn, Fe, Zn, Rb, and Sr concentration in CSF or plasma were similar in all groups. The observed elevations of CSF-Mg, CSF-Ca and CSF-Cu may contribute to or be associated with the neurodegenerative process in DLB. Furthermore, determination of CSF-Mg and CSF-Ca concentration may be a valuable tool in distinguishing DLB from AD. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/18191875/CSF_Mg_and_Ca_as_diagnostic_markers_for_dementia_with_Lewy_bodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(07)00419-8 DB - PRIME DP - Unbound Medicine ER -