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Plasma B-type natriuretic peptide for early diagnosis of allograft rejection after renal transplantation.
Med Hypotheses. 2008; 70(6):1160-2.MH

Abstract

B-type natriuretic peptides are predominantly synthesized in the ventricular myocytes. This is the response to volume overload or increased stress to the ventricular wall. Plasma B-type natriuretic peptide levels are elevated in patients with chronic renal failure due to reduced glomerular filtration and/or increased myocardial biosynthesis. Allograft renal transplantation significantly reduces plasma B-type natriuretic peptide. Our previous clinical observations have demonstrated that acute allograft renal rejection is associated with a sudden increase in plasma B-type natriuretic peptides. We hypothesized that plasma B-type natriuretic peptide may be used as a sensitive and specific biomarker for clinical diagnosis of acute allograft renal rejection.

Authors+Show Affiliations

Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China. suntongwen@163.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18191909

Citation

Sun, Tong-Wen, et al. "Plasma B-type Natriuretic Peptide for Early Diagnosis of Allograft Rejection After Renal Transplantation." Medical Hypotheses, vol. 70, no. 6, 2008, pp. 1160-2.
Sun TW, Zhang SY, Wang LX. Plasma B-type natriuretic peptide for early diagnosis of allograft rejection after renal transplantation. Med Hypotheses. 2008;70(6):1160-2.
Sun, T. W., Zhang, S. Y., & Wang, L. X. (2008). Plasma B-type natriuretic peptide for early diagnosis of allograft rejection after renal transplantation. Medical Hypotheses, 70(6), 1160-2. https://doi.org/10.1016/j.mehy.2007.03.045
Sun TW, Zhang SY, Wang LX. Plasma B-type Natriuretic Peptide for Early Diagnosis of Allograft Rejection After Renal Transplantation. Med Hypotheses. 2008;70(6):1160-2. PubMed PMID: 18191909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma B-type natriuretic peptide for early diagnosis of allograft rejection after renal transplantation. AU - Sun,Tong-Wen, AU - Zhang,Shou-Yan, AU - Wang,Le-Xin, Y1 - 2008/01/08/ PY - 2007/02/27/received PY - 2007/03/01/accepted PY - 2008/1/15/pubmed PY - 2008/8/14/medline PY - 2008/1/15/entrez SP - 1160 EP - 2 JF - Medical hypotheses JO - Med Hypotheses VL - 70 IS - 6 N2 - B-type natriuretic peptides are predominantly synthesized in the ventricular myocytes. This is the response to volume overload or increased stress to the ventricular wall. Plasma B-type natriuretic peptide levels are elevated in patients with chronic renal failure due to reduced glomerular filtration and/or increased myocardial biosynthesis. Allograft renal transplantation significantly reduces plasma B-type natriuretic peptide. Our previous clinical observations have demonstrated that acute allograft renal rejection is associated with a sudden increase in plasma B-type natriuretic peptides. We hypothesized that plasma B-type natriuretic peptide may be used as a sensitive and specific biomarker for clinical diagnosis of acute allograft renal rejection. SN - 0306-9877 UR - https://www.unboundmedicine.com/medline/citation/18191909/Plasma_B_type_natriuretic_peptide_for_early_diagnosis_of_allograft_rejection_after_renal_transplantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(07)00651-2 DB - PRIME DP - Unbound Medicine ER -