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Magnetic resonance imaging and magnetic resonance cholangiopancreatography findings compared with fecal elastase 1 measurement for the diagnosis of chronic pancreatitis.
Pancreas. 2008 Jan; 36(1):e33-9.P

Abstract

OBJECTIVES

To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration.

METHODS

Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically suspected chronic pancreatitis and 21 healthy volunteers were evaluated. All subjects underwent MRI/MRCP and fecal elastase 1 testing within 1 to 4 weeks' interval. Magnetic resonance cholangiopancreatography images were evaluated according to Cambridge classification. Magnetic resonance imaging of the pancreas was assessed for pancreatic size, signal, and arterial enhancement.

RESULTS

All volunteers had normal fecal elastase 1 levels (>200 microg/g) and normal MRI/MRCP findings. Thirty-one of 56 patients revealed MRI and/or MRCP findings despite normal fecal elastase 1 concentration. Four of 25 patients revealed normal MRI and MRCP findings despite low fecal elastase 1 concentration (<200 microg/g). Magnetic resonance imaging findings of size (P = 0.00001), arterial enhancement (P = 0.00001), and parenchymal signal (P = 0.001) were significantly different among the control group, patients with normal fecal elastase 1 levels, and patients with low fecal elastase 1 levels. Magnetic resonance cholangiopancreatography findings (P = 0.00001), pancreatic size (P = 0.00001), arterial enhancement (P = 0.014), and parenchymal signal (P = 0.004) on MRI correlated with the fecal elastase 1 concentration.

CONCLUSIONS

Magnetic resonance imaging/MRCP findings correlate with fecal elastase 1 concentration and may precede pancreatic exocrine insufficiency in the early stages of chronic pancreatitis.

Authors+Show Affiliations

Department of Radiology, University Hospital Giessen and Marburg, Giessen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18192870

Citation

Bilgin, Mehmet, et al. "Magnetic Resonance Imaging and Magnetic Resonance Cholangiopancreatography Findings Compared With Fecal Elastase 1 Measurement for the Diagnosis of Chronic Pancreatitis." Pancreas, vol. 36, no. 1, 2008, pp. e33-9.
Bilgin M, Bilgin S, Balci NC, et al. Magnetic resonance imaging and magnetic resonance cholangiopancreatography findings compared with fecal elastase 1 measurement for the diagnosis of chronic pancreatitis. Pancreas. 2008;36(1):e33-9.
Bilgin, M., Bilgin, S., Balci, N. C., Momtahen, A. J., Bilgin, Y., Klör, H. U., & Rau, W. S. (2008). Magnetic resonance imaging and magnetic resonance cholangiopancreatography findings compared with fecal elastase 1 measurement for the diagnosis of chronic pancreatitis. Pancreas, 36(1), e33-9. https://doi.org/10.1097/mpa.0b013e318150e557
Bilgin M, et al. Magnetic Resonance Imaging and Magnetic Resonance Cholangiopancreatography Findings Compared With Fecal Elastase 1 Measurement for the Diagnosis of Chronic Pancreatitis. Pancreas. 2008;36(1):e33-9. PubMed PMID: 18192870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic resonance imaging and magnetic resonance cholangiopancreatography findings compared with fecal elastase 1 measurement for the diagnosis of chronic pancreatitis. AU - Bilgin,Mehmet, AU - Bilgin,Sabriye, AU - Balci,N Cem, AU - Momtahen,Amir Javad, AU - Bilgin,Yaşar, AU - Klör,Hans-Ulrich, AU - Rau,Wigbert S, PY - 2008/1/15/pubmed PY - 2008/2/29/medline PY - 2008/1/15/entrez SP - e33 EP - 9 JF - Pancreas JO - Pancreas VL - 36 IS - 1 N2 - OBJECTIVES: To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration. METHODS: Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically suspected chronic pancreatitis and 21 healthy volunteers were evaluated. All subjects underwent MRI/MRCP and fecal elastase 1 testing within 1 to 4 weeks' interval. Magnetic resonance cholangiopancreatography images were evaluated according to Cambridge classification. Magnetic resonance imaging of the pancreas was assessed for pancreatic size, signal, and arterial enhancement. RESULTS: All volunteers had normal fecal elastase 1 levels (>200 microg/g) and normal MRI/MRCP findings. Thirty-one of 56 patients revealed MRI and/or MRCP findings despite normal fecal elastase 1 concentration. Four of 25 patients revealed normal MRI and MRCP findings despite low fecal elastase 1 concentration (<200 microg/g). Magnetic resonance imaging findings of size (P = 0.00001), arterial enhancement (P = 0.00001), and parenchymal signal (P = 0.001) were significantly different among the control group, patients with normal fecal elastase 1 levels, and patients with low fecal elastase 1 levels. Magnetic resonance cholangiopancreatography findings (P = 0.00001), pancreatic size (P = 0.00001), arterial enhancement (P = 0.014), and parenchymal signal (P = 0.004) on MRI correlated with the fecal elastase 1 concentration. CONCLUSIONS: Magnetic resonance imaging/MRCP findings correlate with fecal elastase 1 concentration and may precede pancreatic exocrine insufficiency in the early stages of chronic pancreatitis. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/18192870/Magnetic_resonance_imaging_and_magnetic_resonance_cholangiopancreatography_findings_compared_with_fecal_elastase_1_measurement_for_the_diagnosis_of_chronic_pancreatitis_ L2 - https://doi.org/10.1097/mpa.0b013e318150e557 DB - PRIME DP - Unbound Medicine ER -