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Risk factors for community-acquired urinary tract infection due to quinolone-resistant E. coli.
Infection. 2008 Feb; 36(1):41-5.I

Abstract

BACKGROUND

Resistance to fluoroquinolone drugs is emerging among E. coli causing community acquired urinary tract infections (COMA-UTI).

OBJECTIVES

To evaluate demographic and clinical risk factors associated with COMA-UTI due to quinolone-resistant E. coli (QREc).

METHODS

In this case-control study, clinical and demographic data from 300 COMA-UTI due to E. coli (including 150 QREc) were analyzed.

RESULTS

By univariate analysis QREc was associated to males, older patients, nursing home residents, functionally dependent, dementia, diabetes, cardiovascular diseases, immunosupression, nephrolithiasis, recurrent UTI, invasive procedures, hospitalization, and antibiotic use within previous 6 months. By multivariate analysis, use of ciprofloxacin (OR 20.6 [CI 2.3-179.2], p=0.006) or ofloxacin (OR 7.5 [CI 2.9-19.4], p<0.0001), previous invasive procedure (OR 6.6 [CI 3.0-14.7], p<0.0001), recurrent UTI (OR 4.7 [CI 2.3-9.3], p<0.0001), and previous hospitalization (OR 2.9 [CI 1.4-6], p=0.003) were identified as independent risk factors for COMA-UTI due to QREc.

CONCLUSION

In patients with one or more of the risk factors identified here, the empiric use of quinolones should be reconsidered.

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Authors+Show Affiliations

Colodner R
Clinical Microbiology Laboratory, Ha'Emek Medical Center, 18101, Afula, Israel. colodner_ra@clalit.org.il
Kometiani I
No affiliation info available
Chazan B
No affiliation info available
Raz R
No affiliation info available

MeSH

AdultAgedAged, 80 and overAnalysis of VarianceAnti-Bacterial AgentsCase-Control StudiesCommunity-Acquired InfectionsDrug Resistance, BacterialEscherichia coliEscherichia coli InfectionsFemaleHumansMaleMiddle AgedQuinolonesRisk FactorsUrinary Tract Infections

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18193386

Citation

Colodner, R, et al. "Risk Factors for Community-acquired Urinary Tract Infection Due to Quinolone-resistant E. Coli." Infection, vol. 36, no. 1, 2008, pp. 41-5.
Colodner R, Kometiani I, Chazan B, et al. Risk factors for community-acquired urinary tract infection due to quinolone-resistant E. coli. Infection. 2008;36(1):41-5.
Colodner, R., Kometiani, I., Chazan, B., & Raz, R. (2008). Risk factors for community-acquired urinary tract infection due to quinolone-resistant E. coli. Infection, 36(1), 41-5. https://doi.org/10.1007/s15010-007-7083-y
Colodner R, et al. Risk Factors for Community-acquired Urinary Tract Infection Due to Quinolone-resistant E. Coli. Infection. 2008;36(1):41-5. PubMed PMID: 18193386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for community-acquired urinary tract infection due to quinolone-resistant E. coli. AU - Colodner,R, AU - Kometiani,I, AU - Chazan,B, AU - Raz,R, Y1 - 2008/01/12/ PY - 2007/02/10/received PY - 2007/08/15/accepted PY - 2008/1/15/pubmed PY - 2008/10/31/medline PY - 2008/1/15/entrez SP - 41 EP - 5 JF - Infection JO - Infection VL - 36 IS - 1 N2 - BACKGROUND: Resistance to fluoroquinolone drugs is emerging among E. coli causing community acquired urinary tract infections (COMA-UTI). OBJECTIVES: To evaluate demographic and clinical risk factors associated with COMA-UTI due to quinolone-resistant E. coli (QREc). METHODS: In this case-control study, clinical and demographic data from 300 COMA-UTI due to E. coli (including 150 QREc) were analyzed. RESULTS: By univariate analysis QREc was associated to males, older patients, nursing home residents, functionally dependent, dementia, diabetes, cardiovascular diseases, immunosupression, nephrolithiasis, recurrent UTI, invasive procedures, hospitalization, and antibiotic use within previous 6 months. By multivariate analysis, use of ciprofloxacin (OR 20.6 [CI 2.3-179.2], p=0.006) or ofloxacin (OR 7.5 [CI 2.9-19.4], p<0.0001), previous invasive procedure (OR 6.6 [CI 3.0-14.7], p<0.0001), recurrent UTI (OR 4.7 [CI 2.3-9.3], p<0.0001), and previous hospitalization (OR 2.9 [CI 1.4-6], p=0.003) were identified as independent risk factors for COMA-UTI due to QREc. CONCLUSION: In patients with one or more of the risk factors identified here, the empiric use of quinolones should be reconsidered. SN - 0300-8126 UR - https://www.unboundmedicine.com/medline/citation/18193386/Risk_factors_for_community_acquired_urinary_tract_infection_due_to_quinolone_resistant_E__coli_ L2 - https://doi.org/10.1007/s15010-007-7083-y DB - PRIME DP - Unbound Medicine ER -