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Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy.
Neurogastroenterol Motil. 2008 Apr; 20(4):311-9.NM

Abstract

Gastric emptying of digestible solids occurs after trituration of food particles. Non-digestible solids are thought to empty with phase III of the migrating motor complex (MMC). The aim of this study was to determine if a non-digestible capsule given with a meal empties from the stomach with return of the fasting phase III MMC or during the fed pattern with the solid meal. Fifteen normal subjects underwent antroduodenal manometry and ingestion of a radiolabelled meal and SmartPill wireless pH and pressure capsule. In five subjects, emptying of the SmartPill was studied in the fasting period by ingesting the SmartPill with radiolabelled water. The SmartPill emptied from the stomach within 6 h in 14 of 15 subjects. SmartPill pressure recordings showed high amplitude phasic contractions prior to emptying. SmartPill gastric residence time (261 +/- 22 min) correlated strongly with time to the first phase III MMC (239 +/- 23 min; r = 0.813; P < 0.01) and correlated moderately with solid-phase gastric emptying (r = 0.606 with T-50% and r = 0.565 with T-90%). Nine of 14 subjects emptied the capsule with a phase III MMC. In five subjects, the SmartPill emptied with isolated distal antral contractions. In five subjects ingesting only water, SmartPill gastric residence time (92 +/- 44 min) correlated with the time to the first phase III MMC (87 +/- 30 min; r = 0.979; P < 0.01). The non-digestible SmartPill given with a meal primarily empties from the stomach with the return of phase III MMCs occurring after emptying the solid-phase meal. However, in some subjects, the SmartPill emptied with isolated antral contractions, an unappreciated mechanism for emptying of a non-digestible solid.

Authors+Show Affiliations

Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18194154

Citation

Cassilly, D, et al. "Gastric Emptying of a Non-digestible Solid: Assessment With Simultaneous SmartPill pH and Pressure Capsule, Antroduodenal Manometry, Gastric Emptying Scintigraphy." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 20, no. 4, 2008, pp. 311-9.
Cassilly D, Kantor S, Knight LC, et al. Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy. Neurogastroenterol Motil. 2008;20(4):311-9.
Cassilly, D., Kantor, S., Knight, L. C., Maurer, A. H., Fisher, R. S., Semler, J., & Parkman, H. P. (2008). Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 20(4), 311-9. https://doi.org/10.1111/j.1365-2982.2007.01061.x
Cassilly D, et al. Gastric Emptying of a Non-digestible Solid: Assessment With Simultaneous SmartPill pH and Pressure Capsule, Antroduodenal Manometry, Gastric Emptying Scintigraphy. Neurogastroenterol Motil. 2008;20(4):311-9. PubMed PMID: 18194154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy. AU - Cassilly,D, AU - Kantor,S, AU - Knight,L C, AU - Maurer,A H, AU - Fisher,R S, AU - Semler,J, AU - Parkman,H P, Y1 - 2008/01/13/ PY - 2008/1/16/pubmed PY - 2008/7/9/medline PY - 2008/1/16/entrez SP - 311 EP - 9 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol Motil VL - 20 IS - 4 N2 - Gastric emptying of digestible solids occurs after trituration of food particles. Non-digestible solids are thought to empty with phase III of the migrating motor complex (MMC). The aim of this study was to determine if a non-digestible capsule given with a meal empties from the stomach with return of the fasting phase III MMC or during the fed pattern with the solid meal. Fifteen normal subjects underwent antroduodenal manometry and ingestion of a radiolabelled meal and SmartPill wireless pH and pressure capsule. In five subjects, emptying of the SmartPill was studied in the fasting period by ingesting the SmartPill with radiolabelled water. The SmartPill emptied from the stomach within 6 h in 14 of 15 subjects. SmartPill pressure recordings showed high amplitude phasic contractions prior to emptying. SmartPill gastric residence time (261 +/- 22 min) correlated strongly with time to the first phase III MMC (239 +/- 23 min; r = 0.813; P < 0.01) and correlated moderately with solid-phase gastric emptying (r = 0.606 with T-50% and r = 0.565 with T-90%). Nine of 14 subjects emptied the capsule with a phase III MMC. In five subjects, the SmartPill emptied with isolated distal antral contractions. In five subjects ingesting only water, SmartPill gastric residence time (92 +/- 44 min) correlated with the time to the first phase III MMC (87 +/- 30 min; r = 0.979; P < 0.01). The non-digestible SmartPill given with a meal primarily empties from the stomach with the return of phase III MMCs occurring after emptying the solid-phase meal. However, in some subjects, the SmartPill emptied with isolated antral contractions, an unappreciated mechanism for emptying of a non-digestible solid. SN - 1365-2982 UR - https://www.unboundmedicine.com/medline/citation/18194154/Gastric_emptying_of_a_non_digestible_solid:_assessment_with_simultaneous_SmartPill_pH_and_pressure_capsule_antroduodenal_manometry_gastric_emptying_scintigraphy_ DB - PRIME DP - Unbound Medicine ER -