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The role of BPH, lower urinary tract symptoms, and PSA levels on erectile function of Brazilian men who undergo prostate cancer screening.
J Sex Med 2008; 5(7):1702-7JS

Abstract

INTRODUCTION

Lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) are common problems in middle-aged and older men. Recently, epidemiologic studies have shown significant associations between severity of LUTS and male sexual dysfunction.

AIM

We analyzed the role of prostate enlargement, LUTS, and prostate specific antigen (PSA) levels in the erectile function of Brazilian men who underwent prostate cancer (PCa) screening.

METHOD

We analyzed data from 1,008 consecutive patients enrolled in a PCa screening program. Benign prostatic hyperplasia (BPH) was defined as a prostate weight greater than 30 g as defined by digital rectal examination. For statistical analysis, we used the chi-squared and analysis of variance tests. The odds ratios (OR) for correlation of ED with prostate volume LUTS and PSA were estimated using logistic regression models.

MAIN OUTCOME MEASURE

The American Urological Association (AUA) symptom score for LUTS and the International Index of Erectile Function.

RESULTS

Mean patient age was 61.2 years (45-87) and median PSA value was 1.9 ng/mL. BPH was identified in 48.5% of patients. Mild, moderate, and severe LUTS were found in 52.3%, 30.9%, and 16.8% of cases, respectively. ED was classified as absent, mild, mild to moderate, moderate, and severe in 18.6%, 23.1%, 18.6%, 15.2%, and 24.5%, respectively. While only 5.4% of the patients with no ED presented severe LUTS, this finding was observed in 27.1% of patients with severe ED (P < 0.001). Univariate logistic regression analysis demonstrated that age, prostate volume, AUA symptom score, and PSA levels were significant predictors of ED. However, when controlled for patient age, only LUTS remained as an independent predictor of ED.

CONCLUSIONS

Controlling for patient age, LUTS are independent risk factors for the development of ED among Brazilian men who undergo PCa screening. Antunes AA, Srougi M, Dall'Oglio MF, Vicentini F, Paranhos M, and Freire GC. The role of BPH, lower urinary tract symptoms, and PSA levels on erectile function of Brazilian men who undergo prostate cancer screening.

Authors+Show Affiliations

University of Sao Paulo Medical School-Urology, Sao Paulo, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18194186

Citation

Antunes, Alberto A., et al. "The Role of BPH, Lower Urinary Tract Symptoms, and PSA Levels On Erectile Function of Brazilian Men Who Undergo Prostate Cancer Screening." The Journal of Sexual Medicine, vol. 5, no. 7, 2008, pp. 1702-7.
Antunes AA, Srougi M, Dall'oglio MF, et al. The role of BPH, lower urinary tract symptoms, and PSA levels on erectile function of Brazilian men who undergo prostate cancer screening. J Sex Med. 2008;5(7):1702-7.
Antunes, A. A., Srougi, M., Dall'oglio, M. F., Vicentini, F., Paranhos, M., & Freire, G. C. (2008). The role of BPH, lower urinary tract symptoms, and PSA levels on erectile function of Brazilian men who undergo prostate cancer screening. The Journal of Sexual Medicine, 5(7), pp. 1702-7. doi:10.1111/j.1743-6109.2007.00713.x.
Antunes AA, et al. The Role of BPH, Lower Urinary Tract Symptoms, and PSA Levels On Erectile Function of Brazilian Men Who Undergo Prostate Cancer Screening. J Sex Med. 2008;5(7):1702-7. PubMed PMID: 18194186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of BPH, lower urinary tract symptoms, and PSA levels on erectile function of Brazilian men who undergo prostate cancer screening. AU - Antunes,Alberto A, AU - Srougi,Miguel, AU - Dall'oglio,Marcos F, AU - Vicentini,Fabio, AU - Paranhos,Mario, AU - Freire,Geraldo C, PY - 2008/1/16/pubmed PY - 2008/11/19/medline PY - 2008/1/16/entrez SP - 1702 EP - 7 JF - The journal of sexual medicine JO - J Sex Med VL - 5 IS - 7 N2 - INTRODUCTION: Lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) are common problems in middle-aged and older men. Recently, epidemiologic studies have shown significant associations between severity of LUTS and male sexual dysfunction. AIM: We analyzed the role of prostate enlargement, LUTS, and prostate specific antigen (PSA) levels in the erectile function of Brazilian men who underwent prostate cancer (PCa) screening. METHOD: We analyzed data from 1,008 consecutive patients enrolled in a PCa screening program. Benign prostatic hyperplasia (BPH) was defined as a prostate weight greater than 30 g as defined by digital rectal examination. For statistical analysis, we used the chi-squared and analysis of variance tests. The odds ratios (OR) for correlation of ED with prostate volume LUTS and PSA were estimated using logistic regression models. MAIN OUTCOME MEASURE: The American Urological Association (AUA) symptom score for LUTS and the International Index of Erectile Function. RESULTS: Mean patient age was 61.2 years (45-87) and median PSA value was 1.9 ng/mL. BPH was identified in 48.5% of patients. Mild, moderate, and severe LUTS were found in 52.3%, 30.9%, and 16.8% of cases, respectively. ED was classified as absent, mild, mild to moderate, moderate, and severe in 18.6%, 23.1%, 18.6%, 15.2%, and 24.5%, respectively. While only 5.4% of the patients with no ED presented severe LUTS, this finding was observed in 27.1% of patients with severe ED (P < 0.001). Univariate logistic regression analysis demonstrated that age, prostate volume, AUA symptom score, and PSA levels were significant predictors of ED. However, when controlled for patient age, only LUTS remained as an independent predictor of ED. CONCLUSIONS: Controlling for patient age, LUTS are independent risk factors for the development of ED among Brazilian men who undergo PCa screening. Antunes AA, Srougi M, Dall'Oglio MF, Vicentini F, Paranhos M, and Freire GC. The role of BPH, lower urinary tract symptoms, and PSA levels on erectile function of Brazilian men who undergo prostate cancer screening. SN - 1743-6109 UR - https://www.unboundmedicine.com/medline/citation/18194186/The_role_of_BPH_lower_urinary_tract_symptoms_and_PSA_levels_on_erectile_function_of_Brazilian_men_who_undergo_prostate_cancer_screening_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-6095(15)32085-3 DB - PRIME DP - Unbound Medicine ER -