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[Comparative serological efficacy of the measles vaccine strains Edmonston-Zagreb, Schwarz and AIK-C in Togolese infants of 4-5 months and 8-10 months].
Bull Soc Pathol Exot. 1991; 84(5 Pt 5):873-84.BS

Abstract

To examine the value of vaccinating children against measles at age 4-5 months three groups of children in Togo were randomly assigned to receive high-dose Edmonston-Zagreb, high-dose Schwarz, or AIK-C vaccines at that age. Two other groups were vaccinated at age 8-10 months, with either the standard Schwarz vaccine or the same batch of AIK-C as for early immunization. For the 55% of children who were seronegative before vaccination at age 4-5 months, the seroconversion rates were 96% with the AIK-C, 94% with the Edmonston-Zagreb, and 50% with the high-dose Schwarz. The immune response rates for children who were seropositive before vaccination were estimated to be around 50% with the high-dose Edmonston-Zagreb and AIK-C strains and 10% with the Schwarz strain. The seroconversion rates for vaccination at 8-10 months were 87% for the AIK-C and 68% for the Schwarz strains. Thus vaccinations with the high-dose Edmonston-Zagreb or the AIK-C strain at 4-5 months as good as vaccination with the AIK-C strain at 8-10 months better than vaccination with the standard dose Schwarz strain at 8-10 months. These findings require confirmation by further investigations, particularly epidemiological studies, but they already provide evidence that administration of AIK-C and high-dose Edmonston-Zagreb strains at 4-5 months is at least as effective as vaccination with the standard strains at 8-10 months.

Authors+Show Affiliations

Tidjani O
CHU Lomé, Togo.
Grunitzky B
No affiliation info available
Guérin N
No affiliation info available
Lévy-Bruhl D
No affiliation info available
Lecam N
No affiliation info available
Xuereff C
No affiliation info available
Tatagan K
No affiliation info available

MeSH

Age FactorsAntibodies, ViralHumansInfantMeasles VaccineMeasles virusRandom AllocationTogoVaccination

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

fre

PubMed ID

1819435

Citation

Tidjani, O, et al. "[Comparative Serological Efficacy of the Measles Vaccine Strains Edmonston-Zagreb, Schwarz and AIK-C in Togolese Infants of 4-5 Months and 8-10 Months]." Bulletin De La Societe De Pathologie Exotique (1990), vol. 84, no. 5 Pt 5, 1991, pp. 873-84.
Tidjani O, Grunitzky B, Guérin N, et al. [Comparative serological efficacy of the measles vaccine strains Edmonston-Zagreb, Schwarz and AIK-C in Togolese infants of 4-5 months and 8-10 months]. Bull Soc Pathol Exot. 1991;84(5 Pt 5):873-84.
Tidjani, O., Grunitzky, B., Guérin, N., Lévy-Bruhl, D., Lecam, N., Xuereff, C., & Tatagan, K. (1991). [Comparative serological efficacy of the measles vaccine strains Edmonston-Zagreb, Schwarz and AIK-C in Togolese infants of 4-5 months and 8-10 months]. Bulletin De La Societe De Pathologie Exotique (1990), 84(5 Pt 5), 873-84.
Tidjani O, et al. [Comparative Serological Efficacy of the Measles Vaccine Strains Edmonston-Zagreb, Schwarz and AIK-C in Togolese Infants of 4-5 Months and 8-10 Months]. Bull Soc Pathol Exot. 1991;84(5 Pt 5):873-84. PubMed PMID: 1819435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparative serological efficacy of the measles vaccine strains Edmonston-Zagreb, Schwarz and AIK-C in Togolese infants of 4-5 months and 8-10 months]. AU - Tidjani,O, AU - Grunitzky,B, AU - Guérin,N, AU - Lévy-Bruhl,D, AU - Lecam,N, AU - Xuereff,C, AU - Tatagan,K, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 873 EP - 84 JF - Bulletin de la Societe de pathologie exotique (1990) JO - Bull Soc Pathol Exot VL - 84 IS - 5 Pt 5 N2 - To examine the value of vaccinating children against measles at age 4-5 months three groups of children in Togo were randomly assigned to receive high-dose Edmonston-Zagreb, high-dose Schwarz, or AIK-C vaccines at that age. Two other groups were vaccinated at age 8-10 months, with either the standard Schwarz vaccine or the same batch of AIK-C as for early immunization. For the 55% of children who were seronegative before vaccination at age 4-5 months, the seroconversion rates were 96% with the AIK-C, 94% with the Edmonston-Zagreb, and 50% with the high-dose Schwarz. The immune response rates for children who were seropositive before vaccination were estimated to be around 50% with the high-dose Edmonston-Zagreb and AIK-C strains and 10% with the Schwarz strain. The seroconversion rates for vaccination at 8-10 months were 87% for the AIK-C and 68% for the Schwarz strains. Thus vaccinations with the high-dose Edmonston-Zagreb or the AIK-C strain at 4-5 months as good as vaccination with the AIK-C strain at 8-10 months better than vaccination with the standard dose Schwarz strain at 8-10 months. These findings require confirmation by further investigations, particularly epidemiological studies, but they already provide evidence that administration of AIK-C and high-dose Edmonston-Zagreb strains at 4-5 months is at least as effective as vaccination with the standard strains at 8-10 months. SN - 0037-9085 UR - https://www.unboundmedicine.com/medline/citation/1819435/[Comparative_serological_efficacy_of_the_measles_vaccine_strains_Edmonston_Zagreb_Schwarz_and_AIK_C_in_Togolese_infants_of_4_5_months_and_8_10_months]_ DB - PRIME DP - Unbound Medicine ER -