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Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study.
Arch Neurol 2008; 65(1):89-93AN

Abstract

BACKGROUND

Diabetes and the apolipoprotein E epsilon4 allele (APOE epsilon4) increase the risk for Alzheimer disease (AD). We hypothesize that APOE epsilon4 may modify the risk for AD in individuals with diabetes.

OBJECTIVE

To examine the joint effect of type 2 diabetes and APOE epsilon4 on the risk of AD, AD with vascular dementia (mixed AD), and vascular dementia without AD.

DESIGN

The Cardiovascular Health Study (CHS) Cognition Study (1992-2000) is a prospective study designed to identify all existing and new cases of dementia among study participants. Diagnoses were made according to international criteria for dementia and subtypes. There were 2547 dementia-free participants in the CHS Cognition Study cohort with complete information on APOE epsilon4 and type 2 diabetes status; among these, 411 new cases of dementia developed. Risk of dementia was estimated with a Cox proportional hazard model adjusted for age and other demographic and cardiovascular risk factors.

RESULTS

Compared with those who had neither type 2 diabetes nor APOE epsilon4, those with both factors had a significantly higher risk of AD (hazard ratio, 4.58; 95% confidence interval, 2.18-9.65) and mixed AD (hazard ratio, 3.89; 95% confidence interval, 1.46-10.40).

CONCLUSION

These data suggest that having both diabetes and APOE epsilon4 increases the risk of dementia, especially for AD and mixed AD.

Authors+Show Affiliations

Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Bethesda, MD, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

18195144

Citation

Irie, Fumiko, et al. "Enhanced Risk for Alzheimer Disease in Persons With Type 2 Diabetes and APOE Epsilon4: the Cardiovascular Health Study Cognition Study." Archives of Neurology, vol. 65, no. 1, 2008, pp. 89-93.
Irie F, Fitzpatrick AL, Lopez OL, et al. Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study. Arch Neurol. 2008;65(1):89-93.
Irie, F., Fitzpatrick, A. L., Lopez, O. L., Kuller, L. H., Peila, R., Newman, A. B., & Launer, L. J. (2008). Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study. Archives of Neurology, 65(1), pp. 89-93. doi:10.1001/archneurol.2007.29.
Irie F, et al. Enhanced Risk for Alzheimer Disease in Persons With Type 2 Diabetes and APOE Epsilon4: the Cardiovascular Health Study Cognition Study. Arch Neurol. 2008;65(1):89-93. PubMed PMID: 18195144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study. AU - Irie,Fumiko, AU - Fitzpatrick,Annette L, AU - Lopez,Oscar L, AU - Kuller,Lewis H, AU - Peila,Rita, AU - Newman,Anne B, AU - Launer,Lenore J, PY - 2008/1/16/pubmed PY - 2008/2/15/medline PY - 2008/1/16/entrez SP - 89 EP - 93 JF - Archives of neurology JO - Arch. Neurol. VL - 65 IS - 1 N2 - BACKGROUND: Diabetes and the apolipoprotein E epsilon4 allele (APOE epsilon4) increase the risk for Alzheimer disease (AD). We hypothesize that APOE epsilon4 may modify the risk for AD in individuals with diabetes. OBJECTIVE: To examine the joint effect of type 2 diabetes and APOE epsilon4 on the risk of AD, AD with vascular dementia (mixed AD), and vascular dementia without AD. DESIGN: The Cardiovascular Health Study (CHS) Cognition Study (1992-2000) is a prospective study designed to identify all existing and new cases of dementia among study participants. Diagnoses were made according to international criteria for dementia and subtypes. There were 2547 dementia-free participants in the CHS Cognition Study cohort with complete information on APOE epsilon4 and type 2 diabetes status; among these, 411 new cases of dementia developed. Risk of dementia was estimated with a Cox proportional hazard model adjusted for age and other demographic and cardiovascular risk factors. RESULTS: Compared with those who had neither type 2 diabetes nor APOE epsilon4, those with both factors had a significantly higher risk of AD (hazard ratio, 4.58; 95% confidence interval, 2.18-9.65) and mixed AD (hazard ratio, 3.89; 95% confidence interval, 1.46-10.40). CONCLUSION: These data suggest that having both diabetes and APOE epsilon4 increases the risk of dementia, especially for AD and mixed AD. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/18195144/Enhanced_risk_for_Alzheimer_disease_in_persons_with_type_2_diabetes_and_APOE_epsilon4:_the_Cardiovascular_Health_Study_Cognition_Study_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneurol.2007.29 DB - PRIME DP - Unbound Medicine ER -