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Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.
Rheumatol Int 2008; 28(7):685-91RI

Abstract

Genetic and environmental factors are thought to play roles in the etiopathology of fibromyalgia syndrome (FMS). The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS. One hundred seventy-one women (80 FMS, 91 control) were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for the genotyping analyses. Genotype and allele frequencies were calculated by the chi-square test. Beck depression inventory, state and trait anxiety inventory and symptom checklist-90 revised (SCL-90-R) tests were applied to both patients and controls. There were no observed differences in the frequencies of alleles and genotypes between patients and controls for the COMT, and the two 5-HT2A receptor gene polymorphisms (P>0.05). Our results suggest that the investigated polymorphisms seem not to be the susceptibility factors in etiology of FMS.

Authors+Show Affiliations

Department of Physical Medicine and Rehabilitation, Ondokuzmayis University School of Medicine, 55139 Kurupelit, Samsun, Turkey. tander@omu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18196244

Citation

Tander, Berna, et al. "Polymorphisms of the serotonin-2A Receptor and catechol-O-methyltransferase Genes: a Study On Fibromyalgia Susceptibility." Rheumatology International, vol. 28, no. 7, 2008, pp. 685-91.
Tander B, Gunes S, Boke O, et al. Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatol Int. 2008;28(7):685-91.
Tander, B., Gunes, S., Boke, O., Alayli, G., Kara, N., Bagci, H., & Canturk, F. (2008). Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatology International, 28(7), pp. 685-91. doi:10.1007/s00296-008-0525-8.
Tander B, et al. Polymorphisms of the serotonin-2A Receptor and catechol-O-methyltransferase Genes: a Study On Fibromyalgia Susceptibility. Rheumatol Int. 2008;28(7):685-91. PubMed PMID: 18196244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. AU - Tander,Berna, AU - Gunes,Sezgin, AU - Boke,Omer, AU - Alayli,Gamze, AU - Kara,Nurten, AU - Bagci,Hasan, AU - Canturk,Ferhan, Y1 - 2008/01/15/ PY - 2007/08/04/received PY - 2007/12/16/accepted PY - 2008/1/16/pubmed PY - 2008/7/25/medline PY - 2008/1/16/entrez SP - 685 EP - 91 JF - Rheumatology international JO - Rheumatol. Int. VL - 28 IS - 7 N2 - Genetic and environmental factors are thought to play roles in the etiopathology of fibromyalgia syndrome (FMS). The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS. One hundred seventy-one women (80 FMS, 91 control) were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for the genotyping analyses. Genotype and allele frequencies were calculated by the chi-square test. Beck depression inventory, state and trait anxiety inventory and symptom checklist-90 revised (SCL-90-R) tests were applied to both patients and controls. There were no observed differences in the frequencies of alleles and genotypes between patients and controls for the COMT, and the two 5-HT2A receptor gene polymorphisms (P>0.05). Our results suggest that the investigated polymorphisms seem not to be the susceptibility factors in etiology of FMS. SN - 0172-8172 UR - https://www.unboundmedicine.com/medline/citation/18196244/Polymorphisms_of_the_serotonin_2A_receptor_and_catechol_O_methyltransferase_genes:_a_study_on_fibromyalgia_susceptibility_ L2 - https://dx.doi.org/10.1007/s00296-008-0525-8 DB - PRIME DP - Unbound Medicine ER -