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Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.

Abstract

Genetic and environmental factors are thought to play roles in the etiopathology of fibromyalgia syndrome (FMS). The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS. One hundred seventy-one women (80 FMS, 91 control) were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for the genotyping analyses. Genotype and allele frequencies were calculated by the chi-square test. Beck depression inventory, state and trait anxiety inventory and symptom checklist-90 revised (SCL-90-R) tests were applied to both patients and controls. There were no observed differences in the frequencies of alleles and genotypes between patients and controls for the COMT, and the two 5-HT2A receptor gene polymorphisms (P>0.05). Our results suggest that the investigated polymorphisms seem not to be the susceptibility factors in etiology of FMS.

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  • Authors+Show Affiliations

    ,

    Department of Physical Medicine and Rehabilitation, Ondokuzmayis University School of Medicine, 55139 Kurupelit, Samsun, Turkey. tander@omu.edu.tr

    , , , , ,

    Source

    Rheumatology international 28:7 2008 May pg 685-91

    MeSH

    Adult
    Catechol O-Methyltransferase
    Female
    Fibromyalgia
    Genetic Predisposition to Disease
    Genotype
    Humans
    Middle Aged
    Polymorphism, Single Nucleotide
    Receptor, Serotonin, 5-HT2A

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18196244

    Citation

    Tander, Berna, et al. "Polymorphisms of the serotonin-2A Receptor and catechol-O-methyltransferase Genes: a Study On Fibromyalgia Susceptibility." Rheumatology International, vol. 28, no. 7, 2008, pp. 685-91.
    Tander B, Gunes S, Boke O, et al. Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatol Int. 2008;28(7):685-91.
    Tander, B., Gunes, S., Boke, O., Alayli, G., Kara, N., Bagci, H., & Canturk, F. (2008). Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatology International, 28(7), pp. 685-91. doi:10.1007/s00296-008-0525-8.
    Tander B, et al. Polymorphisms of the serotonin-2A Receptor and catechol-O-methyltransferase Genes: a Study On Fibromyalgia Susceptibility. Rheumatol Int. 2008;28(7):685-91. PubMed PMID: 18196244.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. AU - Tander,Berna, AU - Gunes,Sezgin, AU - Boke,Omer, AU - Alayli,Gamze, AU - Kara,Nurten, AU - Bagci,Hasan, AU - Canturk,Ferhan, Y1 - 2008/01/15/ PY - 2007/08/04/received PY - 2007/12/16/accepted PY - 2008/1/16/pubmed PY - 2008/7/25/medline PY - 2008/1/16/entrez SP - 685 EP - 91 JF - Rheumatology international JO - Rheumatol. Int. VL - 28 IS - 7 N2 - Genetic and environmental factors are thought to play roles in the etiopathology of fibromyalgia syndrome (FMS). The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS. One hundred seventy-one women (80 FMS, 91 control) were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for the genotyping analyses. Genotype and allele frequencies were calculated by the chi-square test. Beck depression inventory, state and trait anxiety inventory and symptom checklist-90 revised (SCL-90-R) tests were applied to both patients and controls. There were no observed differences in the frequencies of alleles and genotypes between patients and controls for the COMT, and the two 5-HT2A receptor gene polymorphisms (P>0.05). Our results suggest that the investigated polymorphisms seem not to be the susceptibility factors in etiology of FMS. SN - 0172-8172 UR - https://www.unboundmedicine.com/medline/citation/18196244/Polymorphisms_of_the_serotonin_2A_receptor_and_catechol_O_methyltransferase_genes:_a_study_on_fibromyalgia_susceptibility_ L2 - https://dx.doi.org/10.1007/s00296-008-0525-8 DB - PRIME DP - Unbound Medicine ER -