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Analysis of volatile components of drugs and explosives by solid phase microextraction-ion mobility spectrometry.
J Sep Sci. 2008 Feb; 31(2):402-12.JS

Abstract

Current ion mobility spectrometry (IMS) devices are used to detect drugs and explosives in the form of particles and, in cases where the vapor pressure of the drugs or explosives is sufficiently high, the gas can be sampled and detected directly. The aim of this study is to demonstrate the use of solid phase microextraction (SPME) as a preconcentration technique coupled to an IMS for the detection of odor signature compounds of drugs and explosives. The reduced mobilities (K(o)) and IMS operating conditions for the odor signature compounds of cocaine, marijuana, and 3,4-methylenedioxy-N-methylamphetamine (MDMA) are reported for the first time. LODs, linear dynamic ranges (LDRs), and the precision of the analysis of these odor signature compounds, and the explosive taggant 2,3-dimethyl-2,3-dinitrobutane (DMNB) were obtained by SPME-IMS and normal IMS conditions. The systematic optimization of the IMS operating parameters for the detection of these odor compounds is also reported incorporating the use of genetic algorithms (GAs) for finding the optimal settings for the detection of these compounds of interest. These results support the case for targeting volatile components as a presumptive detection for the presence of the parent compounds of drugs and explosives. Furthermore, the IMS-specific GA developed can be used as an optimization tool for the detection of other compounds of interest in future work.

Authors+Show Affiliations

Department of Chemistry and Biochemistry, International Forensic Research Institute, Florida International University, FL 33199, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18196520

Citation

Lai, Hanh, et al. "Analysis of Volatile Components of Drugs and Explosives By Solid Phase Microextraction-ion Mobility Spectrometry." Journal of Separation Science, vol. 31, no. 2, 2008, pp. 402-12.
Lai H, Guerra P, Joshi M, et al. Analysis of volatile components of drugs and explosives by solid phase microextraction-ion mobility spectrometry. J Sep Sci. 2008;31(2):402-12.
Lai, H., Guerra, P., Joshi, M., & Almirall, J. R. (2008). Analysis of volatile components of drugs and explosives by solid phase microextraction-ion mobility spectrometry. Journal of Separation Science, 31(2), 402-12. https://doi.org/10.1002/jssc.200700292
Lai H, et al. Analysis of Volatile Components of Drugs and Explosives By Solid Phase Microextraction-ion Mobility Spectrometry. J Sep Sci. 2008;31(2):402-12. PubMed PMID: 18196520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of volatile components of drugs and explosives by solid phase microextraction-ion mobility spectrometry. AU - Lai,Hanh, AU - Guerra,Patricia, AU - Joshi,Monica, AU - Almirall,José R, PY - 2008/1/16/pubmed PY - 2008/5/6/medline PY - 2008/1/16/entrez SP - 402 EP - 12 JF - Journal of separation science JO - J Sep Sci VL - 31 IS - 2 N2 - Current ion mobility spectrometry (IMS) devices are used to detect drugs and explosives in the form of particles and, in cases where the vapor pressure of the drugs or explosives is sufficiently high, the gas can be sampled and detected directly. The aim of this study is to demonstrate the use of solid phase microextraction (SPME) as a preconcentration technique coupled to an IMS for the detection of odor signature compounds of drugs and explosives. The reduced mobilities (K(o)) and IMS operating conditions for the odor signature compounds of cocaine, marijuana, and 3,4-methylenedioxy-N-methylamphetamine (MDMA) are reported for the first time. LODs, linear dynamic ranges (LDRs), and the precision of the analysis of these odor signature compounds, and the explosive taggant 2,3-dimethyl-2,3-dinitrobutane (DMNB) were obtained by SPME-IMS and normal IMS conditions. The systematic optimization of the IMS operating parameters for the detection of these odor compounds is also reported incorporating the use of genetic algorithms (GAs) for finding the optimal settings for the detection of these compounds of interest. These results support the case for targeting volatile components as a presumptive detection for the presence of the parent compounds of drugs and explosives. Furthermore, the IMS-specific GA developed can be used as an optimization tool for the detection of other compounds of interest in future work. SN - 1615-9306 UR - https://www.unboundmedicine.com/medline/citation/18196520/Analysis_of_volatile_components_of_drugs_and_explosives_by_solid_phase_microextraction_ion_mobility_spectrometry_ L2 - https://doi.org/10.1002/jssc.200700292 DB - PRIME DP - Unbound Medicine ER -