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Organocatalysed asymmetric Mannich reactions.
Chem Soc Rev. 2008 Jan; 37(1):29-41.CS

Abstract

The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C-C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Verkade JM
Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, NL-6525 ED Nijmegen, The Netherlands.
van Hemert LJ
No affiliation info available
Quaedflieg PJ
No affiliation info available
Rutjes FP
No affiliation info available

MeSH

AcetatesAcidsAlcoholsAldehydesAminesCatalysisEstersIminesKetonesStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18197331

Citation

Verkade, Jorge M M., et al. "Organocatalysed Asymmetric Mannich Reactions." Chemical Society Reviews, vol. 37, no. 1, 2008, pp. 29-41.
Verkade JM, van Hemert LJ, Quaedflieg PJ, et al. Organocatalysed asymmetric Mannich reactions. Chem Soc Rev. 2008;37(1):29-41.
Verkade, J. M., van Hemert, L. J., Quaedflieg, P. J., & Rutjes, F. P. (2008). Organocatalysed asymmetric Mannich reactions. Chemical Society Reviews, 37(1), 29-41. https://doi.org/10.1039/b713885g
Verkade JM, et al. Organocatalysed Asymmetric Mannich Reactions. Chem Soc Rev. 2008;37(1):29-41. PubMed PMID: 18197331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Organocatalysed asymmetric Mannich reactions. AU - Verkade,Jorge M M, AU - van Hemert,Lieke J C, AU - Quaedflieg,Peter J L M, AU - Rutjes,Floris P J T, Y1 - 2007/10/30/ PY - 2008/1/17/pubmed PY - 2008/3/14/medline PY - 2008/1/17/entrez SP - 29 EP - 41 JF - Chemical Society reviews JO - Chem Soc Rev VL - 37 IS - 1 N2 - The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C-C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems. SN - 0306-0012 UR - https://www.unboundmedicine.com/medline/citation/18197331/Organocatalysed_asymmetric_Mannich_reactions_ DB - PRIME DP - Unbound Medicine ER -