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Association between duration of untreated psychosis, premorbid functioning, and cognitive performance and the outcome of first-episode schizophrenia in Japanese patients: prospective study.
Aust N Z J Psychiatry. 2008 Feb; 42(2):159-65.AN

Abstract

OBJECTIVE

The aim of the present study was to identify the relationship between duration of untreated psychosis (DUP), premorbid functioning, and cognitive dysfunction and the outcome of first-episode schizophrenia.

METHOD

Thirty-four neuroleptic-naïve patients who consulted hospitals in Tokyo and who were treated by psychiatrists for the first time were evaluated with regard to DUP, premorbid functioning, psychiatric symptoms, and global functioning. The neuropsychological test battery consisted of the Letter Cancellation Test, Trail-Making Test, Digit Span and Verbal Fluency Test. One year later, 24 of the subjects were reassessed for psychiatric symptoms, global functioning, and social functioning, and the relationships between DUP, premorbid functioning, and cognitive performance and the outcome was investigated.

RESULTS

Short DUP, good premorbid functioning, and good Letter Cancellation Test, Digit Span and Verbal Fluency Test scores were significantly associated with good outcome.

CONCLUSIONS

The present results in a Japanese sample are consistent with previous international evidence that delay of initial treatment, premorbid functioning, and cognitive deficits are associated with outcome. A major limitation of the present study was the small size of the subject group. But because the subjects were relatively homogeneous and not influenced by psychoactive substances, the results reflect the essence of the disorder.

Authors+Show Affiliations

Department of Neuropsychiatry, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18197512

Citation

Yamazawa, Ryoko, et al. "Association Between Duration of Untreated Psychosis, Premorbid Functioning, and Cognitive Performance and the Outcome of First-episode Schizophrenia in Japanese Patients: Prospective Study." The Australian and New Zealand Journal of Psychiatry, vol. 42, no. 2, 2008, pp. 159-65.
Yamazawa R, Nemoto T, Kobayashi H, et al. Association between duration of untreated psychosis, premorbid functioning, and cognitive performance and the outcome of first-episode schizophrenia in Japanese patients: prospective study. Aust N Z J Psychiatry. 2008;42(2):159-65.
Yamazawa, R., Nemoto, T., Kobayashi, H., Chino, B., Kashima, H., & Mizuno, M. (2008). Association between duration of untreated psychosis, premorbid functioning, and cognitive performance and the outcome of first-episode schizophrenia in Japanese patients: prospective study. The Australian and New Zealand Journal of Psychiatry, 42(2), 159-65. https://doi.org/10.1080/00048670701787537
Yamazawa R, et al. Association Between Duration of Untreated Psychosis, Premorbid Functioning, and Cognitive Performance and the Outcome of First-episode Schizophrenia in Japanese Patients: Prospective Study. Aust N Z J Psychiatry. 2008;42(2):159-65. PubMed PMID: 18197512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between duration of untreated psychosis, premorbid functioning, and cognitive performance and the outcome of first-episode schizophrenia in Japanese patients: prospective study. AU - Yamazawa,Ryoko, AU - Nemoto,Takahiro, AU - Kobayashi,Hiroyuki, AU - Chino,Bun, AU - Kashima,Haruo, AU - Mizuno,Masafumi, PY - 2008/1/17/pubmed PY - 2008/4/15/medline PY - 2008/1/17/entrez SP - 159 EP - 65 JF - The Australian and New Zealand journal of psychiatry JO - Aust N Z J Psychiatry VL - 42 IS - 2 N2 - OBJECTIVE: The aim of the present study was to identify the relationship between duration of untreated psychosis (DUP), premorbid functioning, and cognitive dysfunction and the outcome of first-episode schizophrenia. METHOD: Thirty-four neuroleptic-naïve patients who consulted hospitals in Tokyo and who were treated by psychiatrists for the first time were evaluated with regard to DUP, premorbid functioning, psychiatric symptoms, and global functioning. The neuropsychological test battery consisted of the Letter Cancellation Test, Trail-Making Test, Digit Span and Verbal Fluency Test. One year later, 24 of the subjects were reassessed for psychiatric symptoms, global functioning, and social functioning, and the relationships between DUP, premorbid functioning, and cognitive performance and the outcome was investigated. RESULTS: Short DUP, good premorbid functioning, and good Letter Cancellation Test, Digit Span and Verbal Fluency Test scores were significantly associated with good outcome. CONCLUSIONS: The present results in a Japanese sample are consistent with previous international evidence that delay of initial treatment, premorbid functioning, and cognitive deficits are associated with outcome. A major limitation of the present study was the small size of the subject group. But because the subjects were relatively homogeneous and not influenced by psychoactive substances, the results reflect the essence of the disorder. SN - 0004-8674 UR - https://www.unboundmedicine.com/medline/citation/18197512/Association_between_duration_of_untreated_psychosis_premorbid_functioning_and_cognitive_performance_and_the_outcome_of_first_episode_schizophrenia_in_Japanese_patients:_prospective_study_ L2 - https://journals.sagepub.com/doi/10.1080/00048670701787537?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -