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Factors affecting the release of nifedipine from a swellable elementary osmotic pump.
Drug Deliv. 2008 Jan; 15(1):43-8.DD

Abstract

Oral osmotic devices including an elementary osmotic pump (EOP) are efficient systems for the delivery of drugs with high/moderately water-solubility. In this study we designed a new type of EOP for the efficient delivery of poorly water-soluble and practically insoluble drugs. In this system, called swellable elementary osmotic pump (SEOP), drug is released from the delivery orifice in the form of a very fine dispersion of drug in gel which is ready for dissolution and absorption. Factors affecting the release of drug from the SEOP containing a poorly water-soluble drug, nifedipine, were explored extensively. To this end, effect of swelling and wetting agents, orifice size, concentration of osmotic agent, and hydrophobic plasticizer were investigated. Interestingly, in the absence or low concentration of a hydrophobic plasticizer (caster oil), the osmotic devices did not retain their integrity in dissolution media. Caster oil in concentration of > 1% was necessary for tablets to retain their integrity during dissolution process. A zero-order release kinetics for nifedipine was achieved following the effective optimization of the concentrations of swelling agent, osmotic agent, wetting agent, and also size of orifice and membrane thickness in SEOP. The zero-order release lasted for 10 hr at pH 6.8 dissolution medium. The designed SEOP is suggested as an efficient controlled delivery system for oral delivery of a poorly water soluble drug such as nifedipine.

Authors+Show Affiliations

School of Pharmacy at Medway, Universities of Kent and Greenwich, Kent, England. a.nokhodchi@kent.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18197523

Citation

Nokhodchi, Ali, et al. "Factors Affecting the Release of Nifedipine From a Swellable Elementary Osmotic Pump." Drug Delivery, vol. 15, no. 1, 2008, pp. 43-8.
Nokhodchi A, Momin MN, Shokri J, et al. Factors affecting the release of nifedipine from a swellable elementary osmotic pump. Drug Deliv. 2008;15(1):43-8.
Nokhodchi, A., Momin, M. N., Shokri, J., Shahsavari, M., & Rashidi, P. A. (2008). Factors affecting the release of nifedipine from a swellable elementary osmotic pump. Drug Delivery, 15(1), 43-8. https://doi.org/10.1080/10717540701829028
Nokhodchi A, et al. Factors Affecting the Release of Nifedipine From a Swellable Elementary Osmotic Pump. Drug Deliv. 2008;15(1):43-8. PubMed PMID: 18197523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors affecting the release of nifedipine from a swellable elementary osmotic pump. AU - Nokhodchi,Ali, AU - Momin,Mohammed N, AU - Shokri,Javad, AU - Shahsavari,Mahbobeh, AU - Rashidi,Parinaz Ahmad, PY - 2008/1/17/pubmed PY - 2008/5/20/medline PY - 2008/1/17/entrez SP - 43 EP - 8 JF - Drug delivery JO - Drug Deliv VL - 15 IS - 1 N2 - Oral osmotic devices including an elementary osmotic pump (EOP) are efficient systems for the delivery of drugs with high/moderately water-solubility. In this study we designed a new type of EOP for the efficient delivery of poorly water-soluble and practically insoluble drugs. In this system, called swellable elementary osmotic pump (SEOP), drug is released from the delivery orifice in the form of a very fine dispersion of drug in gel which is ready for dissolution and absorption. Factors affecting the release of drug from the SEOP containing a poorly water-soluble drug, nifedipine, were explored extensively. To this end, effect of swelling and wetting agents, orifice size, concentration of osmotic agent, and hydrophobic plasticizer were investigated. Interestingly, in the absence or low concentration of a hydrophobic plasticizer (caster oil), the osmotic devices did not retain their integrity in dissolution media. Caster oil in concentration of > 1% was necessary for tablets to retain their integrity during dissolution process. A zero-order release kinetics for nifedipine was achieved following the effective optimization of the concentrations of swelling agent, osmotic agent, wetting agent, and also size of orifice and membrane thickness in SEOP. The zero-order release lasted for 10 hr at pH 6.8 dissolution medium. The designed SEOP is suggested as an efficient controlled delivery system for oral delivery of a poorly water soluble drug such as nifedipine. SN - 1071-7544 UR - https://www.unboundmedicine.com/medline/citation/18197523/Factors_affecting_the_release_of_nifedipine_from_a_swellable_elementary_osmotic_pump_ L2 - https://www.tandfonline.com/doi/full/10.1080/10717540701829028 DB - PRIME DP - Unbound Medicine ER -