Tags

Type your tag names separated by a space and hit enter

Risk and protective factors for sporadic Alzheimer's disease.

Abstract

Alzheimer's disease (AD) is the most common form of senile dementia. There are 24.3 million people suffering from this progressive neurodegenerative disorder worldwide. A century ago, AD was characterized with regard to the clinical manifestations and pathology for the first time. Up till now, there is a lack of full understanding of the underlying causes and molecular mechanisms leading to this progressive form of dementia. The majority of AD cases occur sporadically, what suggested that they could arise through interactions among various genetic and environmental factors. Current epidemiological investigations show that midlife hypertension, cardiovascular diseases, hypercholesterolemia, diabetes, obesity, inflammation, and viral infections can significantly contribute to the development and progression of AD, whereas active engagement in social, mental and physical activities may delay the onset of the disease. Apolipoprotein E (ApoE) is considered as the main genetic risk factor in the sporadic AD that is closely connected to lipid metabolism. Other genes involved in the disease pathways related to AD pathology in addition to cholesterol metabolism, neuroinflammation, amyloid and tau cascade, neuronal signalling, and plasticity are under investigation. In spite of the significant progress achieved, it is still not clear how genetic vulnerability and environmental exposures may contribute to the susceptibility of the disease. Therefore, understanding the role of disease-related risk factors for AD pathogenesis may help to identify specific modifiable risk factors that could provide possibility for the prevention of Alzheimer's dementia.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic.

    ,

    Source

    Acta virologica 51:4 2007 pg 205-22

    MeSH

    Alzheimer Disease
    Apolipoproteins E
    Humans
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    18197729

    Citation

    Stozická, Z, et al. "Risk and Protective Factors for Sporadic Alzheimer's Disease." Acta Virologica, vol. 51, no. 4, 2007, pp. 205-22.
    Stozická Z, Zilka N, Novák M. Risk and protective factors for sporadic Alzheimer's disease. Acta Virol. 2007;51(4):205-22.
    Stozická, Z., Zilka, N., & Novák, M. (2007). Risk and protective factors for sporadic Alzheimer's disease. Acta Virologica, 51(4), pp. 205-22.
    Stozická Z, Zilka N, Novák M. Risk and Protective Factors for Sporadic Alzheimer's Disease. Acta Virol. 2007;51(4):205-22. PubMed PMID: 18197729.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Risk and protective factors for sporadic Alzheimer's disease. AU - Stozická,Z, AU - Zilka,N, AU - Novák,M, PY - 2008/1/17/pubmed PY - 2008/4/9/medline PY - 2008/1/17/entrez SP - 205 EP - 22 JF - Acta virologica JO - Acta Virol. VL - 51 IS - 4 N2 - Alzheimer's disease (AD) is the most common form of senile dementia. There are 24.3 million people suffering from this progressive neurodegenerative disorder worldwide. A century ago, AD was characterized with regard to the clinical manifestations and pathology for the first time. Up till now, there is a lack of full understanding of the underlying causes and molecular mechanisms leading to this progressive form of dementia. The majority of AD cases occur sporadically, what suggested that they could arise through interactions among various genetic and environmental factors. Current epidemiological investigations show that midlife hypertension, cardiovascular diseases, hypercholesterolemia, diabetes, obesity, inflammation, and viral infections can significantly contribute to the development and progression of AD, whereas active engagement in social, mental and physical activities may delay the onset of the disease. Apolipoprotein E (ApoE) is considered as the main genetic risk factor in the sporadic AD that is closely connected to lipid metabolism. Other genes involved in the disease pathways related to AD pathology in addition to cholesterol metabolism, neuroinflammation, amyloid and tau cascade, neuronal signalling, and plasticity are under investigation. In spite of the significant progress achieved, it is still not clear how genetic vulnerability and environmental exposures may contribute to the susceptibility of the disease. Therefore, understanding the role of disease-related risk factors for AD pathogenesis may help to identify specific modifiable risk factors that could provide possibility for the prevention of Alzheimer's dementia. SN - 0001-723X UR - https://www.unboundmedicine.com/medline/citation/18197729/Risk_and_protective_factors_for_sporadic_Alzheimer's_disease_ L2 - http://www.aepress.sk/_downloads/dl.php?from=pubmed&journal=AV&file=2007_04_205.pdf DB - PRIME DP - Unbound Medicine ER -