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Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood.
Thorax 2008; 63(6):507-13T

Abstract

INTRODUCTION

Dietary intake of specific nutrients or food groups during pregnancy could play a role in the risk of asthma and atopy in offspring, but specific dietary patterns have not been implicated. The authors evaluated the impact of maternal (during pregnancy) and child adherence to a Mediterranean diet on asthma and atopy in childhood.

METHODS

Women presenting for antenatal care at all general practices in Menorca, a Mediterranean island in Spain, over a 12 month period starting in mid-1997 were recruited. 460 children were included in the analysis after 6.5 years of follow-up. Maternal dietary intake during pregnancy and children's dietary intake at age 6.5 years were assessed by food frequency questionnaires, and adherence to a Mediterranean diet was evaluated by a priori defined scores. During follow-up, parents completed questionnaires on the child's respiratory and allergic symptoms. Children underwent skin prick tests with six common aeroallergens.

RESULTS

The prevalence rates of persistent wheeze, atopic wheeze and atopy at age 6.5 years were 13.2%, 5.8% and 17.0%, respectively. One-third (36.1%) of mothers had a low quality Mediterranean diet during pregnancy according to the Mediterranean Diet Score, while the rest had a high score. A high Mediterranean Diet Score during pregnancy (at two levels, using "low" score as the reference) was found to be protective for persistent wheeze (OR 0.22; 95% CI 0.08 to 0.58), atopic wheeze (OR 0.30; 95% CI 0.10 to 0.90) and atopy (OR 0.55; 95% CI 0.31 to 0.97) at age 6.5 years after adjusting for potential confounders. Childhood adherence to a Mediterranean diet was negatively associated with persistent wheeze and atopy although the associations did not reach statistical significance.

CONCLUSION

These results support a protective effect of a high level of adherence to a Mediterranean diet during pregnancy against asthma-like symptoms and atopy in childhood.

Authors+Show Affiliations

Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, Heraklion, 71003, Crete, Greece. lchatzi@med.uoc.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

18198206

Citation

Chatzi, L, et al. "Mediterranean Diet in Pregnancy Is Protective for Wheeze and Atopy in Childhood." Thorax, vol. 63, no. 6, 2008, pp. 507-13.
Chatzi L, Torrent M, Romieu I, et al. Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood. Thorax. 2008;63(6):507-13.
Chatzi, L., Torrent, M., Romieu, I., Garcia-Esteban, R., Ferrer, C., Vioque, J., ... Sunyer, J. (2008). Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood. Thorax, 63(6), pp. 507-13. doi:10.1136/thx.2007.081745.
Chatzi L, et al. Mediterranean Diet in Pregnancy Is Protective for Wheeze and Atopy in Childhood. Thorax. 2008;63(6):507-13. PubMed PMID: 18198206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood. AU - Chatzi,L, AU - Torrent,M, AU - Romieu,I, AU - Garcia-Esteban,R, AU - Ferrer,C, AU - Vioque,J, AU - Kogevinas,M, AU - Sunyer,J, Y1 - 2008/01/15/ PY - 2008/1/17/pubmed PY - 2008/7/17/medline PY - 2008/1/17/entrez SP - 507 EP - 13 JF - Thorax JO - Thorax VL - 63 IS - 6 N2 - INTRODUCTION: Dietary intake of specific nutrients or food groups during pregnancy could play a role in the risk of asthma and atopy in offspring, but specific dietary patterns have not been implicated. The authors evaluated the impact of maternal (during pregnancy) and child adherence to a Mediterranean diet on asthma and atopy in childhood. METHODS: Women presenting for antenatal care at all general practices in Menorca, a Mediterranean island in Spain, over a 12 month period starting in mid-1997 were recruited. 460 children were included in the analysis after 6.5 years of follow-up. Maternal dietary intake during pregnancy and children's dietary intake at age 6.5 years were assessed by food frequency questionnaires, and adherence to a Mediterranean diet was evaluated by a priori defined scores. During follow-up, parents completed questionnaires on the child's respiratory and allergic symptoms. Children underwent skin prick tests with six common aeroallergens. RESULTS: The prevalence rates of persistent wheeze, atopic wheeze and atopy at age 6.5 years were 13.2%, 5.8% and 17.0%, respectively. One-third (36.1%) of mothers had a low quality Mediterranean diet during pregnancy according to the Mediterranean Diet Score, while the rest had a high score. A high Mediterranean Diet Score during pregnancy (at two levels, using "low" score as the reference) was found to be protective for persistent wheeze (OR 0.22; 95% CI 0.08 to 0.58), atopic wheeze (OR 0.30; 95% CI 0.10 to 0.90) and atopy (OR 0.55; 95% CI 0.31 to 0.97) at age 6.5 years after adjusting for potential confounders. Childhood adherence to a Mediterranean diet was negatively associated with persistent wheeze and atopy although the associations did not reach statistical significance. CONCLUSION: These results support a protective effect of a high level of adherence to a Mediterranean diet during pregnancy against asthma-like symptoms and atopy in childhood. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/18198206/Mediterranean_diet_in_pregnancy_is_protective_for_wheeze_and_atopy_in_childhood_ L2 - http://thorax.bmj.com/cgi/pmidlookup?view=long&pmid=18198206 DB - PRIME DP - Unbound Medicine ER -