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[Effect of panax quinquefolius saponin on insulin sensitivity in patients of coronary heart disease with blood glucose abnormality].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Dec; 27(12):1066-9.ZZ

Abstract

OBJECTIVE

To investigate the effect of panax quinquefolius saponin(PQS) on blood glucose, blood lipid and insulin sensitivity in patients of coronary heart disease (CHD) with blood glucose abnormality (BGA).

METHODS

Eighty-four patients of CHD with BGA, namely CHD patients with impaired fasting glucose (IFG), or impaired glucose tolerance (IGT), or type 2 diabetes mellitus (T2DM), were randomly assigned to the PQS group (43 cases) and the control group (41 cases), all were treated with routine Western medicine, but to patients in the PQS group PQS was given orally for 4 successive weeks in addition. Levels of fasting plasma glucose (FPG), fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) were detected both before and after treatment, and insulin sensitive index (ISI) as well as the insulin resistance index and function of beta cells of homostasis model (Homa-IR and Homa-beta) were calculated accordingly.

RESULTS

After treatment, FPG decreased predominantly in both groups (P < 0.01), and the decrement in the PQS group showed a greater trend (25.80 +/- 12.72) % vs (20.89 +/- 12.17) %, but with no statistical significance; no obvious change in levels of FINS, ISI and Homa-IR was found in two groups (P > 0.05). Homa-beta value, which showed insignificantly difference before treatment, increased markedly in the PQS group after treatment from 3.48 +/- 0.76 to 4.19 +/- 0.79 (P < 0.01), which was higher obviously than the unchanged value of Homa-beta in the control group (3.82 +/- 0.77, P < 0.05). There was also decreasing of TC and LDL-C levels after treatment in the PQS group (P < 0.05), and the TC level in the PQS group (1.17 +/- 0.54) mmol/L was significantly lower than that in the control group [(1.42 +/- 0.49) mmol/L, P < 0.05) after treatment.

CONCLUSION

Compared with using it alone, routine Western medicine treatment, by combining with PQS showed superiority in lowering FPG, could significantly decrease the levels of TC and LDL-C, and might improve the beta-cell function in patients of CHD with BGA. It showed no effect on insulin sensitivity of patients, in spite of in combining or not with PQS.

Authors+Show Affiliations

Zhang Y
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing.
Lu S
No affiliation info available
Liu YY
No affiliation info available

MeSH

AgedAntihypertensive AgentsCholesterolCholesterol, LDLCoronary DiseaseDrug Therapy, CombinationFemaleGinsenosidesHumansHyperglycemiaHypoglycemic AgentsInsulin ResistanceMaleMiddle AgedPhytotherapySaponinsTreatment Outcome

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18198636

Citation

Zhang, Ying, et al. "[Effect of Panax Quinquefolius Saponin On Insulin Sensitivity in Patients of Coronary Heart Disease With Blood Glucose Abnormality]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 27, no. 12, 2007, pp. 1066-9.
Zhang Y, Lu S, Liu YY. [Effect of panax quinquefolius saponin on insulin sensitivity in patients of coronary heart disease with blood glucose abnormality]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(12):1066-9.
Zhang, Y., Lu, S., & Liu, Y. Y. (2007). [Effect of panax quinquefolius saponin on insulin sensitivity in patients of coronary heart disease with blood glucose abnormality]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 27(12), 1066-9.
Zhang Y, Lu S, Liu YY. [Effect of Panax Quinquefolius Saponin On Insulin Sensitivity in Patients of Coronary Heart Disease With Blood Glucose Abnormality]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27(12):1066-9. PubMed PMID: 18198636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of panax quinquefolius saponin on insulin sensitivity in patients of coronary heart disease with blood glucose abnormality]. AU - Zhang,Ying, AU - Lu,Shu, AU - Liu,Yu-Ying, PY - 2008/1/18/pubmed PY - 2008/12/17/medline PY - 2008/1/18/entrez SP - 1066 EP - 9 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 27 IS - 12 N2 - OBJECTIVE: To investigate the effect of panax quinquefolius saponin(PQS) on blood glucose, blood lipid and insulin sensitivity in patients of coronary heart disease (CHD) with blood glucose abnormality (BGA). METHODS: Eighty-four patients of CHD with BGA, namely CHD patients with impaired fasting glucose (IFG), or impaired glucose tolerance (IGT), or type 2 diabetes mellitus (T2DM), were randomly assigned to the PQS group (43 cases) and the control group (41 cases), all were treated with routine Western medicine, but to patients in the PQS group PQS was given orally for 4 successive weeks in addition. Levels of fasting plasma glucose (FPG), fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) were detected both before and after treatment, and insulin sensitive index (ISI) as well as the insulin resistance index and function of beta cells of homostasis model (Homa-IR and Homa-beta) were calculated accordingly. RESULTS: After treatment, FPG decreased predominantly in both groups (P < 0.01), and the decrement in the PQS group showed a greater trend (25.80 +/- 12.72) % vs (20.89 +/- 12.17) %, but with no statistical significance; no obvious change in levels of FINS, ISI and Homa-IR was found in two groups (P > 0.05). Homa-beta value, which showed insignificantly difference before treatment, increased markedly in the PQS group after treatment from 3.48 +/- 0.76 to 4.19 +/- 0.79 (P < 0.01), which was higher obviously than the unchanged value of Homa-beta in the control group (3.82 +/- 0.77, P < 0.05). There was also decreasing of TC and LDL-C levels after treatment in the PQS group (P < 0.05), and the TC level in the PQS group (1.17 +/- 0.54) mmol/L was significantly lower than that in the control group [(1.42 +/- 0.49) mmol/L, P < 0.05) after treatment. CONCLUSION: Compared with using it alone, routine Western medicine treatment, by combining with PQS showed superiority in lowering FPG, could significantly decrease the levels of TC and LDL-C, and might improve the beta-cell function in patients of CHD with BGA. It showed no effect on insulin sensitivity of patients, in spite of in combining or not with PQS. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/18198636/[Effect_of_panax_quinquefolius_saponin_on_insulin_sensitivity_in_patients_of_coronary_heart_disease_with_blood_glucose_abnormality]_ DB - PRIME DP - Unbound Medicine ER -