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Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats.
Exerc Immunol Rev. 2007; 13:76-88.EI

Abstract

AIM

We aimed to examine the effect of Coenzyme Q10 (CoQ10) supplementation on the exhaustive exercise-induced injury and oxidative stress in skeletal muscle and liver.

METHODS

Rats were divided into four groups: rest group [control (Con)-Rest; n = 6)], exercise group (Con-Ex; n = 6), rest group with CoQ10 supplement (CoQ10-Rest; n = 6), and exercise group with CoQ10 supplement (CoQ10-Ex; n = 6). The exercise groups were run on a treadmill until exhaustion. The CoQ10 supplemented groups received an oral administration of CoQ10 (300 mg kg(-1), 4 weeks). After 4 weeks, total CoQ concentration, creatine kinase (CK), glutamic-oxaloacetic transaminase (GOT), malondialdehyde (MDA), scavenging activity against reactive oxygen species [ROS; superoxide anions (O2*-) and hydroxyl radicals (HO*)] were measured.

RESULTS

Total CoQ concentration in plasma, slow-twitch muscles (soleus and gastronemius deep portion), and liver were significantly increased by CoQ10 supplementation. Plasma CK was significantly higher in Con-Ex compared with Con-Rest, whereas there was no difference between CoQ10-Rest and CoQ10-Ex. There were no significant differences in muscle MDA in each group. Plasma GOT and liver MDA in exercise groups were significantly higher than that of rest groups, but not significantly different between CoQ10 supplemented groups and control groups. CoQ10 supplementation was not able to favorably influence ROS scavenging activity in skeletal muscle and liver.

CONCLUSIONS

These data indicated that CoQ10 supplementation increased total CoQ concentration in the slow-twitch muscles, and was useful for reducing exhaustive exercise-induced muscular injury by enhancing stabilization of muscle cell membrane.

Authors+Show Affiliations

Graduate School of Comprehensive Human Sciences, Doctoral program of Sports Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18198662

Citation

Kon, Michihiro, et al. "Effect of Coenzyme Q10 Supplementation On Exercise-induced Muscular Injury of Rats." Exercise Immunology Review, vol. 13, 2007, pp. 76-88.
Kon M, Kimura F, Akimoto T, et al. Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats. Exerc Immunol Rev. 2007;13:76-88.
Kon, M., Kimura, F., Akimoto, T., Tanabe, K., Murase, Y., Ikemune, S., & Kono, I. (2007). Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats. Exercise Immunology Review, 13, 76-88.
Kon M, et al. Effect of Coenzyme Q10 Supplementation On Exercise-induced Muscular Injury of Rats. Exerc Immunol Rev. 2007;13:76-88. PubMed PMID: 18198662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats. AU - Kon,Michihiro, AU - Kimura,Fuminori, AU - Akimoto,Takayuki, AU - Tanabe,Kai, AU - Murase,Yosuke, AU - Ikemune,Sachiko, AU - Kono,Ichiro, PY - 2008/1/18/pubmed PY - 2008/2/9/medline PY - 2008/1/18/entrez SP - 76 EP - 88 JF - Exercise immunology review JO - Exerc Immunol Rev VL - 13 N2 - AIM: We aimed to examine the effect of Coenzyme Q10 (CoQ10) supplementation on the exhaustive exercise-induced injury and oxidative stress in skeletal muscle and liver. METHODS: Rats were divided into four groups: rest group [control (Con)-Rest; n = 6)], exercise group (Con-Ex; n = 6), rest group with CoQ10 supplement (CoQ10-Rest; n = 6), and exercise group with CoQ10 supplement (CoQ10-Ex; n = 6). The exercise groups were run on a treadmill until exhaustion. The CoQ10 supplemented groups received an oral administration of CoQ10 (300 mg kg(-1), 4 weeks). After 4 weeks, total CoQ concentration, creatine kinase (CK), glutamic-oxaloacetic transaminase (GOT), malondialdehyde (MDA), scavenging activity against reactive oxygen species [ROS; superoxide anions (O2*-) and hydroxyl radicals (HO*)] were measured. RESULTS: Total CoQ concentration in plasma, slow-twitch muscles (soleus and gastronemius deep portion), and liver were significantly increased by CoQ10 supplementation. Plasma CK was significantly higher in Con-Ex compared with Con-Rest, whereas there was no difference between CoQ10-Rest and CoQ10-Ex. There were no significant differences in muscle MDA in each group. Plasma GOT and liver MDA in exercise groups were significantly higher than that of rest groups, but not significantly different between CoQ10 supplemented groups and control groups. CoQ10 supplementation was not able to favorably influence ROS scavenging activity in skeletal muscle and liver. CONCLUSIONS: These data indicated that CoQ10 supplementation increased total CoQ concentration in the slow-twitch muscles, and was useful for reducing exhaustive exercise-induced muscular injury by enhancing stabilization of muscle cell membrane. SN - 1077-5552 UR - https://www.unboundmedicine.com/medline/citation/18198662/Effect_of_Coenzyme_Q10_supplementation_on_exercise_induced_muscular_injury_of_rats_ L2 - http://eir-isei.de/2007/eir-2007-076-article.pdf DB - PRIME DP - Unbound Medicine ER -