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Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up study.
Clin Infect Dis. 2008 Feb 15; 46(4):507-15.CI

Abstract

BACKGROUND

Previous observational studies found highly active antiretroviral therapy (HAART) to be associated with improved survival among human immunodeficiency virus (HIV)-infected children and adolescents. However, these studies had limited follow-up of HIV-infected children undergoing HAART. Given that HIV infection is chronic and that exposure to HAART is likely to be life-long, there is a need to evaluate the long-term effect of HAART on survival in this population.

METHODS

The study included 1236 children and adolescents who were perinatally infected with HIV, who were on study or enrolled after January 1996 in a United States-based multicenter prospective cohort study (Pediatric AIDS Clinical Trials Group 219/219C), and who were not receiving HAART at baseline; subjects were observed for a maximum of 10 years through June 2006. A weighted Cox regression model was used to estimate the effect of HAART on survival, appropriately adjusted for time-varying confounding by severity.

RESULTS

At the end of the 10-year follow-up period (median duration of follow-up, 6.3 years; interquartile range, 4.3-9.8 years), 70% of participants had initiated HAART. Lower CD4 cell percentages, total lymphocyte counts, and albumin levels were associated with an increased probability of initiating HAART. Eighty-five deaths were observed, and the mortality hazard ratio associated with HAART, compared with non-HAART regimens, was 0.24 after adjusting for measured confounding by severity (95% confidence interval, 0.11-0.51).

CONCLUSIONS

The use of HAART was highly effective in reducing mortality during the period 1996-2006 among children and adolescents infected with HIV. With improved long-term survival, continued follow-up is necessary to evaluate the effects of prolonged use of HAART on potential adverse events, immune function, growth, sexual maturation, and quality of life in this population.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpatel@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18199042

Citation

Patel, Kunjal, et al. "Long-term Effectiveness of Highly Active Antiretroviral Therapy On the Survival of Children and Adolescents With HIV Infection: a 10-year Follow-up Study." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 46, no. 4, 2008, pp. 507-15.
Patel K, Hernán MA, Williams PL, et al. Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up study. Clin Infect Dis. 2008;46(4):507-15.
Patel, K., Hernán, M. A., Williams, P. L., Seeger, J. D., McIntosh, K., Van Dyke, R. B., & Seage, G. R. (2008). Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up study. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 46(4), 507-15. https://doi.org/10.1086/526524
Patel K, et al. Long-term Effectiveness of Highly Active Antiretroviral Therapy On the Survival of Children and Adolescents With HIV Infection: a 10-year Follow-up Study. Clin Infect Dis. 2008 Feb 15;46(4):507-15. PubMed PMID: 18199042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up study. AU - Patel,Kunjal, AU - Hernán,Miguel A, AU - Williams,Paige L, AU - Seeger,John D, AU - McIntosh,Kenneth, AU - Van Dyke,Russell B, AU - Seage,George R,3rd AU - ,, PY - 2008/1/18/pubmed PY - 2008/2/6/medline PY - 2008/1/18/entrez SP - 507 EP - 15 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 46 IS - 4 N2 - BACKGROUND: Previous observational studies found highly active antiretroviral therapy (HAART) to be associated with improved survival among human immunodeficiency virus (HIV)-infected children and adolescents. However, these studies had limited follow-up of HIV-infected children undergoing HAART. Given that HIV infection is chronic and that exposure to HAART is likely to be life-long, there is a need to evaluate the long-term effect of HAART on survival in this population. METHODS: The study included 1236 children and adolescents who were perinatally infected with HIV, who were on study or enrolled after January 1996 in a United States-based multicenter prospective cohort study (Pediatric AIDS Clinical Trials Group 219/219C), and who were not receiving HAART at baseline; subjects were observed for a maximum of 10 years through June 2006. A weighted Cox regression model was used to estimate the effect of HAART on survival, appropriately adjusted for time-varying confounding by severity. RESULTS: At the end of the 10-year follow-up period (median duration of follow-up, 6.3 years; interquartile range, 4.3-9.8 years), 70% of participants had initiated HAART. Lower CD4 cell percentages, total lymphocyte counts, and albumin levels were associated with an increased probability of initiating HAART. Eighty-five deaths were observed, and the mortality hazard ratio associated with HAART, compared with non-HAART regimens, was 0.24 after adjusting for measured confounding by severity (95% confidence interval, 0.11-0.51). CONCLUSIONS: The use of HAART was highly effective in reducing mortality during the period 1996-2006 among children and adolescents infected with HIV. With improved long-term survival, continued follow-up is necessary to evaluate the effects of prolonged use of HAART on potential adverse events, immune function, growth, sexual maturation, and quality of life in this population. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/18199042/Long_term_effectiveness_of_highly_active_antiretroviral_therapy_on_the_survival_of_children_and_adolescents_with_HIV_infection:_a_10_year_follow_up_study_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/526524 DB - PRIME DP - Unbound Medicine ER -