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Effect of vasoactive intestinal peptide (VIP) on the mechanical activity and [3H] acetylcholine release in guinea-pig gastric muscle.
Acta Physiol Pharmacol Bulg. 1991; 17(2-3):13-8.AP

Abstract

Muscle strips, 30 x 3 mm, were cut out in circular direction from the fundus region of the stomach. Mechanical activity was recorded by means of mechanoelectrical force transducers. Vasoactive intestinal peptide (VIP) at concentrations of 10(-9) to 10(-7) M caused a dose-dependent relaxation of muscle strips which was insensitive to tetrodotoxin. Field electrical stimulation (10 Hz, 1 ms, supramaximal voltage) produced contractions, which were blocked by atropine. VIP (10(-9) to 10(-7) M) dose-dependently decreased the amplitude of the electrically-induced contractions. VIP dose-dependently reduced the electrically-stimulated [3H] acetylcholine release. It is suggested that at least two different mechanisms are involved in the VIP-induced relaxation of the gastric muscle: a direct action on the smooth muscle and an indirect action mediated through cholinergic innervation.

Authors+Show Affiliations

Institute of Physiology, Bulgarian Academy of Sciences.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1819910

Citation

Milenov, K, et al. "Effect of Vasoactive Intestinal Peptide (VIP) On the Mechanical Activity and [3H] Acetylcholine Release in Guinea-pig Gastric Muscle." Acta Physiologica Et Pharmacologica Bulgarica, vol. 17, no. 2-3, 1991, pp. 13-8.
Milenov K, Kalfin R, Mandrek K. Effect of vasoactive intestinal peptide (VIP) on the mechanical activity and [3H] acetylcholine release in guinea-pig gastric muscle. Acta Physiol Pharmacol Bulg. 1991;17(2-3):13-8.
Milenov, K., Kalfin, R., & Mandrek, K. (1991). Effect of vasoactive intestinal peptide (VIP) on the mechanical activity and [3H] acetylcholine release in guinea-pig gastric muscle. Acta Physiologica Et Pharmacologica Bulgarica, 17(2-3), 13-8.
Milenov K, Kalfin R, Mandrek K. Effect of Vasoactive Intestinal Peptide (VIP) On the Mechanical Activity and [3H] Acetylcholine Release in Guinea-pig Gastric Muscle. Acta Physiol Pharmacol Bulg. 1991;17(2-3):13-8. PubMed PMID: 1819910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vasoactive intestinal peptide (VIP) on the mechanical activity and [3H] acetylcholine release in guinea-pig gastric muscle. AU - Milenov,K, AU - Kalfin,R, AU - Mandrek,K, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 13 EP - 8 JF - Acta physiologica et pharmacologica Bulgarica JO - Acta Physiol Pharmacol Bulg VL - 17 IS - 2-3 N2 - Muscle strips, 30 x 3 mm, were cut out in circular direction from the fundus region of the stomach. Mechanical activity was recorded by means of mechanoelectrical force transducers. Vasoactive intestinal peptide (VIP) at concentrations of 10(-9) to 10(-7) M caused a dose-dependent relaxation of muscle strips which was insensitive to tetrodotoxin. Field electrical stimulation (10 Hz, 1 ms, supramaximal voltage) produced contractions, which were blocked by atropine. VIP (10(-9) to 10(-7) M) dose-dependently decreased the amplitude of the electrically-induced contractions. VIP dose-dependently reduced the electrically-stimulated [3H] acetylcholine release. It is suggested that at least two different mechanisms are involved in the VIP-induced relaxation of the gastric muscle: a direct action on the smooth muscle and an indirect action mediated through cholinergic innervation. SN - 0323-9950 UR - https://www.unboundmedicine.com/medline/citation/1819910/Effect_of_vasoactive_intestinal_peptide__VIP__on_the_mechanical_activity_and_[3H]_acetylcholine_release_in_guinea_pig_gastric_muscle_ DB - PRIME DP - Unbound Medicine ER -