Citation
Schimmelmann, Benno G., et al. "Impact of Duration of Untreated Psychosis On Pre-treatment, Baseline, and Outcome Characteristics in an Epidemiological First-episode Psychosis Cohort." Journal of Psychiatric Research, vol. 42, no. 12, 2008, pp. 982-90.
Schimmelmann BG, Huber CG, Lambert M, et al. Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort. J Psychiatr Res. 2008;42(12):982-90.
Schimmelmann, B. G., Huber, C. G., Lambert, M., Cotton, S., McGorry, P. D., & Conus, P. (2008). Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort. Journal of Psychiatric Research, 42(12), 982-90. https://doi.org/10.1016/j.jpsychires.2007.12.001
Schimmelmann BG, et al. Impact of Duration of Untreated Psychosis On Pre-treatment, Baseline, and Outcome Characteristics in an Epidemiological First-episode Psychosis Cohort. J Psychiatr Res. 2008;42(12):982-90. PubMed PMID: 18199456.
TY - JOUR
T1 - Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort.
AU - Schimmelmann,Benno G,
AU - Huber,Christian G,
AU - Lambert,Martin,
AU - Cotton,Sue,
AU - McGorry,Patrick D,
AU - Conus,Philippe,
Y1 - 2008/01/15/
PY - 2007/09/06/received
PY - 2007/11/25/revised
PY - 2007/12/05/accepted
PY - 2008/1/18/pubmed
PY - 2008/10/31/medline
PY - 2008/1/18/entrez
SP - 982
EP - 90
JF - Journal of psychiatric research
JO - J Psychiatr Res
VL - 42
IS - 12
N2 - INTRODUCTION: To assess the impact of duration of untreated psychosis (DUP) on baseline and 18-month follow-up characteristics controlling for relevant confounders in an epidemiological first-episode psychosis (FEP) cohort. METHOD: The Early Psychosis Prevention and Intervention Centre (EPPIC) in Australia admitted 786 FEP patients from January 1998 to December 2000. Data were collected from medical files using a standardized questionnaire. Data from 636 patients were analyzed. RESULTS: Median DUP was 8.7 weeks. Longer DUP was associated with worse premorbid functioning (p<0.001), higher rate of schizophrenia-spectrum disorders (p<0.001), and younger age at onset of psychosis (p=0.004). Longer DUP was not associated with baseline variables but with a lower rate of remission of positive symptoms (p<0.001) and employment/occupation (p<0.001), a higher rate of persistent substance use (p=0.015), worse illness severity (p<0.001) and global functioning (p<0.001) at follow-up after controlling for relevant confounders, explaining approximately 5% of variance of remission of positive symptoms (p<0.001) in the total sample and 3% in schizophrenia-spectrum disorders excluding bipolar I disorder (p=0.002). Outcome was significantly worse when DUP exceeded 1-3 months. CONCLUSION: Avoiding pitfalls of non-epidemiological studies, DUP appears to be a modest independent predictor of prognosis in the medium-term. Results support the need for assertive early detection strategies.
SN - 0022-3956
UR - https://www.unboundmedicine.com/medline/citation/18199456/Impact_of_duration_of_untreated_psychosis_on_pre_treatment_baseline_and_outcome_characteristics_in_an_epidemiological_first_episode_psychosis_cohort_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(07)00209-9
DB - PRIME
DP - Unbound Medicine
ER -