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Smoking without exception adversely affects vascular structure and function in apparently healthy Chinese: implications in global atherosclerosis prevention.
Int J Cardiol 2008; 128(2):172-7IJ

Abstract

BACKGROUND

Both active and passive smoking are prevalent in China but cardiovascular diseases were less prevalent in the past. We studied the current relationship between surrogate atherosclerosis markers and smoking in Chinese.

METHODS

Endothelium-dependent flow-mediated dilation (FMD) of brachial artery and carotid intima-media thickness (IMT) were measured non-invasively by ultrasound in 616 apparently healthy Chinese (23% smokers), recruited from greater China and the USA.

RESULTS

The Chinese smokers had significantly impaired FMD (7.0+/-2.3 vs. 8.2+/-2.5%, p<0.001) and endothelium-independent vasodilation (GTN, 17.4+/-3.9 vs. 18.7+/-4.1%, p=0.001) and thicker IMT (0.61+/-0.13 vs. 0.58+/-0.12 mm, p=0.025). 91% of the smokers were male. Both endothelium-dependent (6.9+/-2.2 vs. 8.0+/-2.5%, p<0.001) and independent (17.3+/-3.5 vs. 18.2+/-3.7%, p=0.047) vasodilation were significantly lower in the male smokers than non-smokers, although their age and cholesterol levels were lower. FMD-to-GTN ratio in the smokers were lower (0.41+/-0.12 vs. 0.45+/-0.13, p=0.005). Multivariate analyses confirmed an independent adverse impact of smoking on vascular functions. There were no consistent interactions between subject location and impact of smoking on FMD and IMT.

CONCLUSION

In these apparently healthy native and overseas Chinese subjects, smoking is adversely associated with endothelial dysfunction and arterial wall thickening, with serious implication in atherosclerosis prevention.

Authors+Show Affiliations

The Chinese University of Hong Kong, Shatin, Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18199502

Citation

Thomas, G Neil, et al. "Smoking Without Exception Adversely Affects Vascular Structure and Function in Apparently Healthy Chinese: Implications in Global Atherosclerosis Prevention." International Journal of Cardiology, vol. 128, no. 2, 2008, pp. 172-7.
Thomas GN, Chook P, Yip TW, et al. Smoking without exception adversely affects vascular structure and function in apparently healthy Chinese: implications in global atherosclerosis prevention. Int J Cardiol. 2008;128(2):172-7.
Thomas, G. N., Chook, P., Yip, T. W., Kwong, S. K., Chan, T. Y., Qiao, M., ... Woo, K. S. (2008). Smoking without exception adversely affects vascular structure and function in apparently healthy Chinese: implications in global atherosclerosis prevention. International Journal of Cardiology, 128(2), pp. 172-7. doi:10.1016/j.ijcard.2007.11.065.
Thomas GN, et al. Smoking Without Exception Adversely Affects Vascular Structure and Function in Apparently Healthy Chinese: Implications in Global Atherosclerosis Prevention. Int J Cardiol. 2008 Aug 18;128(2):172-7. PubMed PMID: 18199502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking without exception adversely affects vascular structure and function in apparently healthy Chinese: implications in global atherosclerosis prevention. AU - Thomas,G Neil, AU - Chook,Ping, AU - Yip,Thomas W C, AU - Kwong,Shu K, AU - Chan,Thomas Y K, AU - Qiao,Mu, AU - Huang,Xin S, AU - Guo,Dong S, AU - Feng,Jian Z, AU - Chan,Shu W, AU - Leong,Hok C, AU - Celermajer,David S, AU - Woo,Kam S, Y1 - 2008/01/15/ PY - 2007/05/31/received PY - 2007/09/21/revised PY - 2007/11/02/accepted PY - 2008/1/18/pubmed PY - 2008/10/11/medline PY - 2008/1/18/entrez SP - 172 EP - 7 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 128 IS - 2 N2 - BACKGROUND: Both active and passive smoking are prevalent in China but cardiovascular diseases were less prevalent in the past. We studied the current relationship between surrogate atherosclerosis markers and smoking in Chinese. METHODS: Endothelium-dependent flow-mediated dilation (FMD) of brachial artery and carotid intima-media thickness (IMT) were measured non-invasively by ultrasound in 616 apparently healthy Chinese (23% smokers), recruited from greater China and the USA. RESULTS: The Chinese smokers had significantly impaired FMD (7.0+/-2.3 vs. 8.2+/-2.5%, p<0.001) and endothelium-independent vasodilation (GTN, 17.4+/-3.9 vs. 18.7+/-4.1%, p=0.001) and thicker IMT (0.61+/-0.13 vs. 0.58+/-0.12 mm, p=0.025). 91% of the smokers were male. Both endothelium-dependent (6.9+/-2.2 vs. 8.0+/-2.5%, p<0.001) and independent (17.3+/-3.5 vs. 18.2+/-3.7%, p=0.047) vasodilation were significantly lower in the male smokers than non-smokers, although their age and cholesterol levels were lower. FMD-to-GTN ratio in the smokers were lower (0.41+/-0.12 vs. 0.45+/-0.13, p=0.005). Multivariate analyses confirmed an independent adverse impact of smoking on vascular functions. There were no consistent interactions between subject location and impact of smoking on FMD and IMT. CONCLUSION: In these apparently healthy native and overseas Chinese subjects, smoking is adversely associated with endothelial dysfunction and arterial wall thickening, with serious implication in atherosclerosis prevention. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/18199502/Smoking_without_exception_adversely_affects_vascular_structure_and_function_in_apparently_healthy_Chinese:_implications_in_global_atherosclerosis_prevention_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(07)01986-9 DB - PRIME DP - Unbound Medicine ER -