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Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women.
Cancer Epidemiol Biomarkers Prev. 2008 Jan; 17(1):33-42.CE

Abstract

Only 30% to 50% of people produce the daidzein-metabolite equol after eating soy. We conducted a cross-sectional study of the associations between equol status, intake of soy foods, and mammographic density in a sample of postmenopausal women recruited at a radiology clinic near Buffalo, New York. Participants were 48 to 82 years old, had no history of cancer or breast reduction/augmentation, and no recent use of antibiotics or hormones. Percent density was measured by computer-assisted analysis of digitized images of craniocaudal films. Equol status was assessed using a soy-challenge protocol and usual soy intake by questionnaire. General linear models were used to assess independent and joint effects of equol status and intake of soy on multivariate adjusted percent density (covariates included age, body mass index, parity, age at first birth, and ever use of combined hormone therapy). Of 325 enrolled, 232 (71%) participants completed study assessments and are included in the present analysis. Mean percent density was 34% (+/-18%). Seventy-five (30%) participants were producers of equol. Forty-three (19%) participants reported regularly eating >1 soy food or supplement/wk. There were no significant independent associations of equol status or soy intake with percent density, but the interaction between these factors was significant (P < 0.01). Among equol producers, those with weekly soy intake had lower percent density (30.7% in weekly consumers of soy versus 38.9% in others; P = 0.08); among nonproducers, weekly soy intake was associated with higher percent density (37.5% in weekly soy consumers versus 30.7% in others; P = 0.03). Results suggest that equol producers and nonproducers may experience different effects of dietary soy on breast tissue.

Authors+Show Affiliations

Department of Epidemiology, Italian National Cancer Institute Regina Elena, Via Elio Chianesi 53, Rome, Italy. barbara.fuhrman@gmail.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18199709

Citation

Fuhrman, Barbara J., et al. "Equol Status Modifies the Association of Soy Intake and Mammographic Density in a Sample of Postmenopausal Women." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 1, 2008, pp. 33-42.
Fuhrman BJ, Teter BE, Barba M, et al. Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2008;17(1):33-42.
Fuhrman, B. J., Teter, B. E., Barba, M., Byrne, C., Cavalleri, A., Grant, B. J., Horvath, P. J., Morelli, D., Venturelli, E., & Muti, P. C. (2008). Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(1), 33-42. https://doi.org/10.1158/1055-9965.EPI-07-0193
Fuhrman BJ, et al. Equol Status Modifies the Association of Soy Intake and Mammographic Density in a Sample of Postmenopausal Women. Cancer Epidemiol Biomarkers Prev. 2008;17(1):33-42. PubMed PMID: 18199709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women. AU - Fuhrman,Barbara J, AU - Teter,Barbara E, AU - Barba,Maddalena, AU - Byrne,Celia, AU - Cavalleri,Adalberto, AU - Grant,Brydon J, AU - Horvath,Peter J, AU - Morelli,Daniele, AU - Venturelli,Elisabetta, AU - Muti,Paola C, PY - 2008/1/18/pubmed PY - 2008/4/2/medline PY - 2008/1/18/entrez SP - 33 EP - 42 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 17 IS - 1 N2 - Only 30% to 50% of people produce the daidzein-metabolite equol after eating soy. We conducted a cross-sectional study of the associations between equol status, intake of soy foods, and mammographic density in a sample of postmenopausal women recruited at a radiology clinic near Buffalo, New York. Participants were 48 to 82 years old, had no history of cancer or breast reduction/augmentation, and no recent use of antibiotics or hormones. Percent density was measured by computer-assisted analysis of digitized images of craniocaudal films. Equol status was assessed using a soy-challenge protocol and usual soy intake by questionnaire. General linear models were used to assess independent and joint effects of equol status and intake of soy on multivariate adjusted percent density (covariates included age, body mass index, parity, age at first birth, and ever use of combined hormone therapy). Of 325 enrolled, 232 (71%) participants completed study assessments and are included in the present analysis. Mean percent density was 34% (+/-18%). Seventy-five (30%) participants were producers of equol. Forty-three (19%) participants reported regularly eating >1 soy food or supplement/wk. There were no significant independent associations of equol status or soy intake with percent density, but the interaction between these factors was significant (P < 0.01). Among equol producers, those with weekly soy intake had lower percent density (30.7% in weekly consumers of soy versus 38.9% in others; P = 0.08); among nonproducers, weekly soy intake was associated with higher percent density (37.5% in weekly soy consumers versus 30.7% in others; P = 0.03). Results suggest that equol producers and nonproducers may experience different effects of dietary soy on breast tissue. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18199709/Equol_status_modifies_the_association_of_soy_intake_and_mammographic_density_in_a_sample_of_postmenopausal_women_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=18199709 DB - PRIME DP - Unbound Medicine ER -