Tags

Type your tag names separated by a space and hit enter

Genetic evolution of swine influenza A (H3N2) viruses in China from 1970 to 2006.
J Clin Microbiol 2008; 46(3):1067-75JC

Abstract

Pigs are susceptible to both human and avian influenza viruses and have been proposed to be intermediate hosts, or mixing vessels, for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we summarize and report for the first time the coexistence of wholly human-like H3N2 viruses, double-reassortant H3N2 viruses, and triple-reassortant H3N2 viruses in pigs in China by analyzing the eight genes of swine influenza A (H3N2) viruses found in China from 1970 to 2006. In 1970, the first wholly human-like H3N2 (Hong Kong/68-like) viruses were isolated from pigs in Taiwan, and then in the next years Victoria/75-like, Sydney/97-like, New York/99-like, and Moscow/99-like swine H3N2 viruses were regularly isolated in China. In the 1980s, two triple-reassortant viruses were isolated from pigs. Recently, the double-reassortant viruses containing genes from the human (HA and NA) and avian (PB2, PB1, PA, NP, M, and NS) lineages and the triple-reassortant viruses containing genes from the human (HA and NA), classical swine (NP), and avian (PB2, PB1, PA, M, and NS) lineages emerged in pigs in China. The coexistence of wholly human-like and reassortant viruses provides further evidence that pigs serve as intermediate hosts, or mixing vessels, and emphasizes the importance of reinforcing swine influenza virus surveillance in China.

Authors+Show Affiliations

National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 427 Maduan Street, Harbin 150001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18199784

Citation

Yu, Hai, et al. "Genetic Evolution of Swine Influenza a (H3N2) Viruses in China From 1970 to 2006." Journal of Clinical Microbiology, vol. 46, no. 3, 2008, pp. 1067-75.
Yu H, Hua RH, Zhang Q, et al. Genetic evolution of swine influenza A (H3N2) viruses in China from 1970 to 2006. J Clin Microbiol. 2008;46(3):1067-75.
Yu, H., Hua, R. H., Zhang, Q., Liu, T. Q., Liu, H. L., Li, G. X., & Tong, G. Z. (2008). Genetic evolution of swine influenza A (H3N2) viruses in China from 1970 to 2006. Journal of Clinical Microbiology, 46(3), pp. 1067-75. doi:10.1128/JCM.01257-07.
Yu H, et al. Genetic Evolution of Swine Influenza a (H3N2) Viruses in China From 1970 to 2006. J Clin Microbiol. 2008;46(3):1067-75. PubMed PMID: 18199784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic evolution of swine influenza A (H3N2) viruses in China from 1970 to 2006. AU - Yu,Hai, AU - Hua,Rong-Hong, AU - Zhang,Qiang, AU - Liu,Tian-Qiang, AU - Liu,Hui-Li, AU - Li,Guo-Xin, AU - Tong,Guang-Zhi, Y1 - 2008/01/16/ PY - 2008/1/18/pubmed PY - 2008/4/12/medline PY - 2008/1/18/entrez SP - 1067 EP - 75 JF - Journal of clinical microbiology JO - J. Clin. Microbiol. VL - 46 IS - 3 N2 - Pigs are susceptible to both human and avian influenza viruses and have been proposed to be intermediate hosts, or mixing vessels, for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we summarize and report for the first time the coexistence of wholly human-like H3N2 viruses, double-reassortant H3N2 viruses, and triple-reassortant H3N2 viruses in pigs in China by analyzing the eight genes of swine influenza A (H3N2) viruses found in China from 1970 to 2006. In 1970, the first wholly human-like H3N2 (Hong Kong/68-like) viruses were isolated from pigs in Taiwan, and then in the next years Victoria/75-like, Sydney/97-like, New York/99-like, and Moscow/99-like swine H3N2 viruses were regularly isolated in China. In the 1980s, two triple-reassortant viruses were isolated from pigs. Recently, the double-reassortant viruses containing genes from the human (HA and NA) and avian (PB2, PB1, PA, NP, M, and NS) lineages and the triple-reassortant viruses containing genes from the human (HA and NA), classical swine (NP), and avian (PB2, PB1, PA, M, and NS) lineages emerged in pigs in China. The coexistence of wholly human-like and reassortant viruses provides further evidence that pigs serve as intermediate hosts, or mixing vessels, and emphasizes the importance of reinforcing swine influenza virus surveillance in China. SN - 1098-660X UR - https://www.unboundmedicine.com/medline/citation/18199784/Genetic_evolution_of_swine_influenza_A__H3N2__viruses_in_China_from_1970_to_2006_ L2 - http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=18199784 DB - PRIME DP - Unbound Medicine ER -