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Clinical and histopathological features of the oral mucosa in allogeneic haematopoietic stem cell transplantation patients.
Exp Oncol. 2007 Dec; 29(4):304-8.EO

Abstract

INTRODUCTION

Chronic graft-versus-host disease (cGVHD) is a common but serious complication of allogeneic haematopoietic stem cell transplantation (HSCT). Oral involvement of cGVHD occurs in 80 to 100% of patients suffering from cGVHD and may be the early manifestation of this complication.

AIM

To study whether the histological changes of oral cGVHD are detectable in apparently normal oral mucosa of HSCT patients without clinical manifestations of the disease.

PATIENTS AND METHODS

This study enrolled 13 adult patients who underwent allogeneic HSCT for haematological malignancies. The presence of lichenoid, atrophic or erythematous changes of the oral mucosa detected on oral examination approximately 100 days after the HSCT was regarded as positive for cGVHD. An incisional biopsy of the oral mucosa was taken from patients with and without oral cGVHD and the specimens were examined by a pathologist who was unaware of the clinical state of the sampled mucosa.

RESULTS

Biopsies were taken from four patients with clinical manifestations of oral cGVHD and from nine patients with apparently normal oral mucosa. Histological cGVHD changes were detected in each of the four patients (100%) with clinical manifestations of oral cGVHD and in six of the nine patients (66.6%) with apparently healthy mucosa.

DISCUSSION

Although the histological changes in the oral mucosa without corresponding clinical alterations that were detected in this study are insufficient for a definite diagnosis of oral cGVHD, it appears important to investigate the amount of histological change in predicting clinical onset. A longer follow-up period in patients showing histological changes with no clinical manifestations may elucidate whether these changes are predictive of clinically evident lesions in the mouth or other sites.

Authors+Show Affiliations

Unit of Oral Pathology and Medicine, School of Dentistry, University of Milan, Via Beldiletto 1, 20142 Milan, Italy. federica.demarosi@unimi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18199988

Citation

Demarosi, F, et al. "Clinical and Histopathological Features of the Oral Mucosa in Allogeneic Haematopoietic Stem Cell Transplantation Patients." Experimental Oncology, vol. 29, no. 4, 2007, pp. 304-8.
Demarosi F, Lodi G, Carrassi A, et al. Clinical and histopathological features of the oral mucosa in allogeneic haematopoietic stem cell transplantation patients. Exp Oncol. 2007;29(4):304-8.
Demarosi, F., Lodi, G., Carrassi, A., Moneghini, L., Sarina, B., & Sardella, A. (2007). Clinical and histopathological features of the oral mucosa in allogeneic haematopoietic stem cell transplantation patients. Experimental Oncology, 29(4), 304-8.
Demarosi F, et al. Clinical and Histopathological Features of the Oral Mucosa in Allogeneic Haematopoietic Stem Cell Transplantation Patients. Exp Oncol. 2007;29(4):304-8. PubMed PMID: 18199988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and histopathological features of the oral mucosa in allogeneic haematopoietic stem cell transplantation patients. AU - Demarosi,F, AU - Lodi,G, AU - Carrassi,A, AU - Moneghini,L, AU - Sarina,B, AU - Sardella,A, PY - 2008/1/18/pubmed PY - 2008/4/9/medline PY - 2008/1/18/entrez SP - 304 EP - 8 JF - Experimental oncology JO - Exp Oncol VL - 29 IS - 4 N2 - INTRODUCTION: Chronic graft-versus-host disease (cGVHD) is a common but serious complication of allogeneic haematopoietic stem cell transplantation (HSCT). Oral involvement of cGVHD occurs in 80 to 100% of patients suffering from cGVHD and may be the early manifestation of this complication. AIM: To study whether the histological changes of oral cGVHD are detectable in apparently normal oral mucosa of HSCT patients without clinical manifestations of the disease. PATIENTS AND METHODS: This study enrolled 13 adult patients who underwent allogeneic HSCT for haematological malignancies. The presence of lichenoid, atrophic or erythematous changes of the oral mucosa detected on oral examination approximately 100 days after the HSCT was regarded as positive for cGVHD. An incisional biopsy of the oral mucosa was taken from patients with and without oral cGVHD and the specimens were examined by a pathologist who was unaware of the clinical state of the sampled mucosa. RESULTS: Biopsies were taken from four patients with clinical manifestations of oral cGVHD and from nine patients with apparently normal oral mucosa. Histological cGVHD changes were detected in each of the four patients (100%) with clinical manifestations of oral cGVHD and in six of the nine patients (66.6%) with apparently healthy mucosa. DISCUSSION: Although the histological changes in the oral mucosa without corresponding clinical alterations that were detected in this study are insufficient for a definite diagnosis of oral cGVHD, it appears important to investigate the amount of histological change in predicting clinical onset. A longer follow-up period in patients showing histological changes with no clinical manifestations may elucidate whether these changes are predictive of clinically evident lesions in the mouth or other sites. SN - 1812-9269 UR - https://www.unboundmedicine.com/medline/citation/18199988/Clinical_and_histopathological_features_of_the_oral_mucosa_in_allogeneic_haematopoietic_stem_cell_transplantation_patients_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -