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Scanning laser polarimetry with variable corneal compensation in primary angle-closure glaucoma.
Ophthalmology. 2008 Aug; 115(8):1334-9.O

Abstract

PURPOSE

To evaluate the diagnostic sensitivity of scanning laser polarimetry in primary angle-closure glaucoma (PACG) as compared with that in primary open-angle glaucoma (POAG) and to compare the retinal nerve fiber layer (RNFL) distribution between PACG and POAG.

DESIGN

Prospective, comparative, observational cases series.

PARTICIPANTS

One eye each of 58 PACG patients and 51 POAG patients.

METHODS

Scanning laser polarimetry with variable corneal compensation (GDx VCC).

MAIN OUTCOME MEASURES

GDx VCC temporal-superior-nasal-inferior-temporal (TSNIT) parameters, including TSNIT average, TSNIT standard deviation, superior average, and inferior average, as well as the nerve fiber indicator (NFI).

RESULTS

By using a logistic marginal regression model that defined an abnormal test as P<5% for each of the TSNIT parameters or NFI > or = 31, we found that diagnostic sensitivities of the GDx VCC parameters were similar (all Ps>0.05) in PACG and POAG despite the differences in refraction error (P = 0.017), axial length (P<0.001), and disc diameters (vertical, P = 0.031; horizontal, P = 0.002) between these 2 forms of glaucoma. The between-group similarity in the diagnostic sensitivity remained true either when all eyes were considered together or in each severity group, based on the visual field scoring system adopted by the Advanced Glaucoma Intervention Study. Regarding the RNFL distribution, the parameter inferior average was greater than the superior average in either PACG (P = 0.010) or POAG (P = 0.006). Further subgroup analyses found significant superior-inferior asymmetry in mild PACG (P = 0.022) but not in mild POAG (P = 0.279).

CONCLUSIONS

Eyes with PACG have ocular biometrics and, possibly, pathogeneses of optic nerve damage different from those of eyes with POAG; however, the diagnostic sensitivity of GDx VCC is quite comparable in these 2 forms of glaucoma, irrespective of disease severity.

Authors+Show Affiliations

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan. jlliu@vghtpe.gov.twNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18201763

Citation

Liu, Catherine Jui-ling, et al. "Scanning Laser Polarimetry With Variable Corneal Compensation in Primary Angle-closure Glaucoma." Ophthalmology, vol. 115, no. 8, 2008, pp. 1334-9.
Liu CJ, Cheng CY, Hsu WM. Scanning laser polarimetry with variable corneal compensation in primary angle-closure glaucoma. Ophthalmology. 2008;115(8):1334-9.
Liu, C. J., Cheng, C. Y., & Hsu, W. M. (2008). Scanning laser polarimetry with variable corneal compensation in primary angle-closure glaucoma. Ophthalmology, 115(8), 1334-9. https://doi.org/10.1016/j.ophtha.2007.10.042
Liu CJ, Cheng CY, Hsu WM. Scanning Laser Polarimetry With Variable Corneal Compensation in Primary Angle-closure Glaucoma. Ophthalmology. 2008;115(8):1334-9. PubMed PMID: 18201763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scanning laser polarimetry with variable corneal compensation in primary angle-closure glaucoma. AU - Liu,Catherine Jui-ling, AU - Cheng,Ching-Yu, AU - Hsu,Wen-Ming, Y1 - 2008/01/16/ PY - 2007/03/26/received PY - 2007/10/10/revised PY - 2007/10/31/accepted PY - 2008/1/19/pubmed PY - 2008/8/20/medline PY - 2008/1/19/entrez SP - 1334 EP - 9 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 8 N2 - PURPOSE: To evaluate the diagnostic sensitivity of scanning laser polarimetry in primary angle-closure glaucoma (PACG) as compared with that in primary open-angle glaucoma (POAG) and to compare the retinal nerve fiber layer (RNFL) distribution between PACG and POAG. DESIGN: Prospective, comparative, observational cases series. PARTICIPANTS: One eye each of 58 PACG patients and 51 POAG patients. METHODS: Scanning laser polarimetry with variable corneal compensation (GDx VCC). MAIN OUTCOME MEASURES: GDx VCC temporal-superior-nasal-inferior-temporal (TSNIT) parameters, including TSNIT average, TSNIT standard deviation, superior average, and inferior average, as well as the nerve fiber indicator (NFI). RESULTS: By using a logistic marginal regression model that defined an abnormal test as P<5% for each of the TSNIT parameters or NFI > or = 31, we found that diagnostic sensitivities of the GDx VCC parameters were similar (all Ps>0.05) in PACG and POAG despite the differences in refraction error (P = 0.017), axial length (P<0.001), and disc diameters (vertical, P = 0.031; horizontal, P = 0.002) between these 2 forms of glaucoma. The between-group similarity in the diagnostic sensitivity remained true either when all eyes were considered together or in each severity group, based on the visual field scoring system adopted by the Advanced Glaucoma Intervention Study. Regarding the RNFL distribution, the parameter inferior average was greater than the superior average in either PACG (P = 0.010) or POAG (P = 0.006). Further subgroup analyses found significant superior-inferior asymmetry in mild PACG (P = 0.022) but not in mild POAG (P = 0.279). CONCLUSIONS: Eyes with PACG have ocular biometrics and, possibly, pathogeneses of optic nerve damage different from those of eyes with POAG; however, the diagnostic sensitivity of GDx VCC is quite comparable in these 2 forms of glaucoma, irrespective of disease severity. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/18201763/Scanning_laser_polarimetry_with_variable_corneal_compensation_in_primary_angle_closure_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)01216-X DB - PRIME DP - Unbound Medicine ER -