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Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 01; 32(3):761-4.PN

Abstract

BACKGROUND

Recent studies indicate that the traditional Japanese herbal medicine yi-gan san (YGS, yokukan-san in Japanese), a serotonin modulator, may be safe and useful in treating behavioral and psychological symptoms in dementia and borderline personality disorder patients. The authors examined the efficacy, tolerability, and safety of YGS in patients with tardive dyskinesia.

METHODS

Twenty-two patients with schizophrenia who had neuroleptic-induced tardive dyskinesia were given 7.5 g/day of YGS for 12 weeks in an open-label study.

RESULTS

Administration of YGS resulted in a statistically significant improvement in tardive dyskinesia and psychotic symptoms.

CONCLUSIONS

YGS may be an effective and safe therapy to control tardive dyskinesia and psychosis in patients with schizophrenia, that should be further tested in double-blind, placebo-controlled trials.

Authors+Show Affiliations

Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo, 693-8501, Japan. miyanyan@med.shimane-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18201810

Citation

Miyaoka, Tsuyoshi, et al. "Yi-gan San for the Treatment of Neuroleptic-induced Tardive Dyskinesia: an Open-label Study." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 3, 2008, pp. 761-4.
Miyaoka T, Furuya M, Yasuda H, et al. Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(3):761-4.
Miyaoka, T., Furuya, M., Yasuda, H., Hayashida, M., Nishida, A., Inagaki, T., & Horiguchi, J. (2008). Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(3), 761-4. https://doi.org/10.1016/j.pnpbp.2007.12.003
Miyaoka T, et al. Yi-gan San for the Treatment of Neuroleptic-induced Tardive Dyskinesia: an Open-label Study. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):761-4. PubMed PMID: 18201810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study. AU - Miyaoka,Tsuyoshi, AU - Furuya,Motohide, AU - Yasuda,Hideaki, AU - Hayashida,Maiko, AU - Nishida,Akira, AU - Inagaki,Takuji, AU - Horiguchi,Jun, Y1 - 2007/12/14/ PY - 2007/09/13/received PY - 2007/11/18/revised PY - 2007/12/06/accepted PY - 2008/1/19/pubmed PY - 2008/7/3/medline PY - 2008/1/19/entrez SP - 761 EP - 4 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 32 IS - 3 N2 - BACKGROUND: Recent studies indicate that the traditional Japanese herbal medicine yi-gan san (YGS, yokukan-san in Japanese), a serotonin modulator, may be safe and useful in treating behavioral and psychological symptoms in dementia and borderline personality disorder patients. The authors examined the efficacy, tolerability, and safety of YGS in patients with tardive dyskinesia. METHODS: Twenty-two patients with schizophrenia who had neuroleptic-induced tardive dyskinesia were given 7.5 g/day of YGS for 12 weeks in an open-label study. RESULTS: Administration of YGS resulted in a statistically significant improvement in tardive dyskinesia and psychotic symptoms. CONCLUSIONS: YGS may be an effective and safe therapy to control tardive dyskinesia and psychosis in patients with schizophrenia, that should be further tested in double-blind, placebo-controlled trials. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/18201810/Yi_gan_san_for_the_treatment_of_neuroleptic_induced_tardive_dyskinesia:_an_open_label_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00431-9 DB - PRIME DP - Unbound Medicine ER -