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Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry?
Clin Chem 2008; 54(3):550-8CC

Abstract

BACKGROUND

Insulin, growth hormone (GH), and growth factors (insulin-like growth factors [IGFs] and their binding proteins [IGFBPs]) are known to influence fetal growth and also the synthesis/secretion of the recently discovered hormones leptin and ghrelin.

METHODS

In 153 delivering mothers and their offspring at birth, we prospectively investigated the association between mothers' and babies' serum concentrations of ghrelin, leptin, insulin, IGF-1, and IGFBP-3 and neonatal anthropometric characteristics and the growth of the fetus. We also tried to put babies' serum glucose and GH measurements in this context.

RESULTS

Birth weight (BW), birth length, head circumference, and ponderal index (PI) were positively associated with cord IGF-1, IGFBP-3, and leptin and negatively associated with GH. BW was independently associated with maternal stature and prepartum weight, birth length with maternal stature, PI with maternal insulin and prepartum weight, and head circumference with maternal ghrelin. Compared with preterm infants whose development was appropriate for gestational age (AGA), preterm growth-restricted babies displayed alteration in GH-IGF axis (increased GH and low IGF-1 and IGFBP-3 concentrations), low leptin and glucose concentrations, and increased ghrelin concentrations. In large-for-gestational-age (LGA) babies, leptin, IGFBP-3, insulin, and glucose concentrations were significantly higher in asymmetric LGA newborns than in symmetric LGA and AGA newborns.

CONCLUSIONS

We found relationships between metabolic factors, fetal growth, and anthropometry. Intrauterine growth restriction involved alteration in the fetal GH-IGF axis, with relatively low leptin and glucose concentrations and increased ghrelin concentrations. Leptin, insulin, and IGFBP-3 delineated subtypes of fetal overgrowth.

Authors+Show Affiliations

Department of Pediatrics, La Sapienza University of Rome, Viale Regina Elena, 32400161 Rome, Italy. claudio.chiesa@uniroma1.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18202160

Citation

Chiesa, Claudio, et al. "Ghrelin, Leptin, IGF-1, IGFBP-3, and Insulin Concentrations at Birth: Is There a Relationship With Fetal Growth and Neonatal Anthropometry?" Clinical Chemistry, vol. 54, no. 3, 2008, pp. 550-8.
Chiesa C, Osborn JF, Haass C, et al. Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry? Clin Chem. 2008;54(3):550-8.
Chiesa, C., Osborn, J. F., Haass, C., Natale, F., Spinelli, M., Scapillati, E., ... Pacifico, L. (2008). Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry? Clinical Chemistry, 54(3), pp. 550-8. doi:10.1373/clinchem.2007.095299.
Chiesa C, et al. Ghrelin, Leptin, IGF-1, IGFBP-3, and Insulin Concentrations at Birth: Is There a Relationship With Fetal Growth and Neonatal Anthropometry. Clin Chem. 2008;54(3):550-8. PubMed PMID: 18202160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry? AU - Chiesa,Claudio, AU - Osborn,John F, AU - Haass,Cristina, AU - Natale,Fabio, AU - Spinelli,Marina, AU - Scapillati,Eleonora, AU - Spinelli,Angela, AU - Pacifico,Lucia, Y1 - 2008/01/17/ PY - 2008/1/19/pubmed PY - 2008/5/14/medline PY - 2008/1/19/entrez SP - 550 EP - 8 JF - Clinical chemistry JO - Clin. Chem. VL - 54 IS - 3 N2 - BACKGROUND: Insulin, growth hormone (GH), and growth factors (insulin-like growth factors [IGFs] and their binding proteins [IGFBPs]) are known to influence fetal growth and also the synthesis/secretion of the recently discovered hormones leptin and ghrelin. METHODS: In 153 delivering mothers and their offspring at birth, we prospectively investigated the association between mothers' and babies' serum concentrations of ghrelin, leptin, insulin, IGF-1, and IGFBP-3 and neonatal anthropometric characteristics and the growth of the fetus. We also tried to put babies' serum glucose and GH measurements in this context. RESULTS: Birth weight (BW), birth length, head circumference, and ponderal index (PI) were positively associated with cord IGF-1, IGFBP-3, and leptin and negatively associated with GH. BW was independently associated with maternal stature and prepartum weight, birth length with maternal stature, PI with maternal insulin and prepartum weight, and head circumference with maternal ghrelin. Compared with preterm infants whose development was appropriate for gestational age (AGA), preterm growth-restricted babies displayed alteration in GH-IGF axis (increased GH and low IGF-1 and IGFBP-3 concentrations), low leptin and glucose concentrations, and increased ghrelin concentrations. In large-for-gestational-age (LGA) babies, leptin, IGFBP-3, insulin, and glucose concentrations were significantly higher in asymmetric LGA newborns than in symmetric LGA and AGA newborns. CONCLUSIONS: We found relationships between metabolic factors, fetal growth, and anthropometry. Intrauterine growth restriction involved alteration in the fetal GH-IGF axis, with relatively low leptin and glucose concentrations and increased ghrelin concentrations. Leptin, insulin, and IGFBP-3 delineated subtypes of fetal overgrowth. SN - 0009-9147 UR - https://www.unboundmedicine.com/medline/citation/18202160/Ghrelin_leptin_IGF_1_IGFBP_3_and_insulin_concentrations_at_birth:_is_there_a_relationship_with_fetal_growth_and_neonatal_anthropometry L2 - http://www.clinchem.org/cgi/pmidlookup?view=long&pmid=18202160 DB - PRIME DP - Unbound Medicine ER -