Tags

Type your tag names separated by a space and hit enter

Fibrinogen genes and myocardial infarction: a haplotype analysis.
Arterioscler Thromb Vasc Biol. 2008 Apr; 28(4):758-63.AT

Abstract

OBJECTIVE

Fibrinogen has a role in inflammatory processes and participates in atherosclerotic plaque formation. Despite intensive investigation, there is no clear evidence for a role of variations in the genes coding for the fibrinogen-alpha, fibrinogen-beta, and fibrinogen-gamma polypeptide chains in myocardial infarction. We examined the association of haplotypes in the 50-kb fibrinogen gene region with myocardial infarction in 2 large case-control samples.

METHODS AND RESULTS

Study sample 1 consisted of 3657 patients with myocardial infarction and 1211 control individuals and sample 2 comprised 1392 patients and 1392 controls. Haplotypes were inferred from genotype analyses of tagging single nucleotide polymorphisms dispersed among the fibrinogen genes. The frequencies of these haplotypes were not significantly different between the case and control groups in either sample (P > or = 0.07). In addition, haplotypes specific for individual fibrinogen genes were analyzed. No substantial differences in the frequencies of these haplotypes were observed between the groups (P > or = 0.13). Finally, haplotypes composed of SNPs that exhibited relatively low pairwise allelic associations among each other were examined. The proportions of the haplotypes were not significantly different between cases and controls (P > or = 0.12).

CONCLUSIONS

A haplotype analysis did not reveal a link between genetic variations in the fibrinogen gene region and myocardial infarction.

Authors+Show Affiliations

Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Munich, Germany. wkoch@dhm.mhn.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18202324

Citation

Koch, Werner, et al. "Fibrinogen Genes and Myocardial Infarction: a Haplotype Analysis." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 4, 2008, pp. 758-63.
Koch W, Hoppmann P, Biele J, et al. Fibrinogen genes and myocardial infarction: a haplotype analysis. Arterioscler Thromb Vasc Biol. 2008;28(4):758-63.
Koch, W., Hoppmann, P., Biele, J., Mueller, J. C., Schömig, A., & Kastrati, A. (2008). Fibrinogen genes and myocardial infarction: a haplotype analysis. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(4), 758-63. https://doi.org/10.1161/ATVBAHA.107.157842
Koch W, et al. Fibrinogen Genes and Myocardial Infarction: a Haplotype Analysis. Arterioscler Thromb Vasc Biol. 2008;28(4):758-63. PubMed PMID: 18202324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibrinogen genes and myocardial infarction: a haplotype analysis. AU - Koch,Werner, AU - Hoppmann,Petra, AU - Biele,Janita, AU - Mueller,Jakob C, AU - Schömig,Albert, AU - Kastrati,Adnan, Y1 - 2008/01/17/ PY - 2008/1/19/pubmed PY - 2008/4/22/medline PY - 2008/1/19/entrez SP - 758 EP - 63 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler Thromb Vasc Biol VL - 28 IS - 4 N2 - OBJECTIVE: Fibrinogen has a role in inflammatory processes and participates in atherosclerotic plaque formation. Despite intensive investigation, there is no clear evidence for a role of variations in the genes coding for the fibrinogen-alpha, fibrinogen-beta, and fibrinogen-gamma polypeptide chains in myocardial infarction. We examined the association of haplotypes in the 50-kb fibrinogen gene region with myocardial infarction in 2 large case-control samples. METHODS AND RESULTS: Study sample 1 consisted of 3657 patients with myocardial infarction and 1211 control individuals and sample 2 comprised 1392 patients and 1392 controls. Haplotypes were inferred from genotype analyses of tagging single nucleotide polymorphisms dispersed among the fibrinogen genes. The frequencies of these haplotypes were not significantly different between the case and control groups in either sample (P > or = 0.07). In addition, haplotypes specific for individual fibrinogen genes were analyzed. No substantial differences in the frequencies of these haplotypes were observed between the groups (P > or = 0.13). Finally, haplotypes composed of SNPs that exhibited relatively low pairwise allelic associations among each other were examined. The proportions of the haplotypes were not significantly different between cases and controls (P > or = 0.12). CONCLUSIONS: A haplotype analysis did not reveal a link between genetic variations in the fibrinogen gene region and myocardial infarction. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/18202324/Fibrinogen_genes_and_myocardial_infarction:_a_haplotype_analysis_ L2 - https://www.ahajournals.org/doi/10.1161/ATVBAHA.107.157842?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -