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Comparison of induced sputum and bronchoalveolar lavage fluid cell profile during the treatment of pulmonary sarcoidosis.
J Physiol Pharmacol. 2007 Nov; 58 Suppl 5(Pt 2):445-52.JP

Abstract

In this study we compared the cellular profiles of induced sputum (IS) and BAL in newly diagnosed sarcoidosis patients before and after 6 months of prednisone therapy. The study encompassed 17 untreated patients with stage II pulmonary sarcoidosis. Sputum was induced with hypertonic saline solution, and bronchoscopy was performed in all patients. The results showed a significantly higher percentage of macrophages in BAL (P<0.05), whereas the percentage of neutrophils was higher in IS samples (P<0.01). The percentage of lymphocytes in IS was significantly lower than that in BAL (P<0.05). The TCD4/CD8 ratio was in favor of CD4 in both BAL and IS samples before prednisone therapy and it significantly decreased after therapy; the ratio was 4.8 vs. 1.8 (P=0.009) in BAL and 3.5 vs. 2.0 (P=0.019) in IS, respectively. Positive BAL/IS correlation characterized T cell populations in regards to CD4+ (r=0.59), CD8+ (r=0.34), CD4/CD8 ratio (r= 0.66) and CD3+ HLA-DR+ (r=0.89) cell population. These finding suggest that IS may serve as a valuable alternative to BAL technique.

Authors+Show Affiliations

Department of Pulmonology, Bialystok Medical University, Bialystok, Poland. robmroz@wp.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18204157

Citation

Mroz, R M., et al. "Comparison of Induced Sputum and Bronchoalveolar Lavage Fluid Cell Profile During the Treatment of Pulmonary Sarcoidosis." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 58 Suppl 5, no. Pt 2, 2007, pp. 445-52.
Mroz RM, Korniluk M, Stasiak-Barmuta A, et al. Comparison of induced sputum and bronchoalveolar lavage fluid cell profile during the treatment of pulmonary sarcoidosis. J Physiol Pharmacol. 2007;58 Suppl 5(Pt 2):445-52.
Mroz, R. M., Korniluk, M., Stasiak-Barmuta, A., & Chyczewska, E. (2007). Comparison of induced sputum and bronchoalveolar lavage fluid cell profile during the treatment of pulmonary sarcoidosis. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 58 Suppl 5(Pt 2), 445-52.
Mroz RM, et al. Comparison of Induced Sputum and Bronchoalveolar Lavage Fluid Cell Profile During the Treatment of Pulmonary Sarcoidosis. J Physiol Pharmacol. 2007;58 Suppl 5(Pt 2):445-52. PubMed PMID: 18204157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of induced sputum and bronchoalveolar lavage fluid cell profile during the treatment of pulmonary sarcoidosis. AU - Mroz,R M, AU - Korniluk,M, AU - Stasiak-Barmuta,A, AU - Chyczewska,E, PY - 2008/3/28/pubmed PY - 2008/4/16/medline PY - 2008/3/28/entrez SP - 445 EP - 52 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 58 Suppl 5 IS - Pt 2 N2 - In this study we compared the cellular profiles of induced sputum (IS) and BAL in newly diagnosed sarcoidosis patients before and after 6 months of prednisone therapy. The study encompassed 17 untreated patients with stage II pulmonary sarcoidosis. Sputum was induced with hypertonic saline solution, and bronchoscopy was performed in all patients. The results showed a significantly higher percentage of macrophages in BAL (P<0.05), whereas the percentage of neutrophils was higher in IS samples (P<0.01). The percentage of lymphocytes in IS was significantly lower than that in BAL (P<0.05). The TCD4/CD8 ratio was in favor of CD4 in both BAL and IS samples before prednisone therapy and it significantly decreased after therapy; the ratio was 4.8 vs. 1.8 (P=0.009) in BAL and 3.5 vs. 2.0 (P=0.019) in IS, respectively. Positive BAL/IS correlation characterized T cell populations in regards to CD4+ (r=0.59), CD8+ (r=0.34), CD4/CD8 ratio (r= 0.66) and CD3+ HLA-DR+ (r=0.89) cell population. These finding suggest that IS may serve as a valuable alternative to BAL technique. SN - 0867-5910 UR - https://www.unboundmedicine.com/medline/citation/18204157/Comparison_of_induced_sputum_and_bronchoalveolar_lavage_fluid_cell_profile_during_the_treatment_of_pulmonary_sarcoidosis_ L2 - http://www.jpp.krakow.pl/journal/archive/11_07_s5/pdf/445_11_07_s5_article.pdf DB - PRIME DP - Unbound Medicine ER -