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Antibody response to influenza vaccination in patients suffering from asthma.
J Physiol Pharmacol. 2007 Nov; 58 Suppl 5(Pt 2):583-9.JP

Abstract

The aim of the study was to assess humoral response to influenza vaccination in 20 children with bronchial asthma vaccinated with split inactivated vaccine. Response to influenza hemagglutinin was assessed before vaccination and after 1 month by hemagglutination inhibition test. Antibody titers were significantly higher after vaccination than before vaccination. The mean fold increase of antibody levels ranged after vaccination from 12.2 to 53.7. The post-vaccination percentage of patients with protective antihemagglutinin antibody titers>or=40 ranged from 95% to 100%. The percentage of patients with at least a 4-fold increase of anthemagglutinin antibody titers ranged after vaccination from 90% to 100%. The results confirmed the immunogenicity and safety of inactivated influenza vaccine in children with asthma. The registered values of all parameters of the immunological response (mean fold increase, protection rate, response rate) fulfilled the requirements of the Committee for Proprietary Medicinal Products established for healthy people vaccinated against influenza.

Authors+Show Affiliations

Romanowska M
National Influenza Center, National Institute of Hygiene, Warsaw, Poland. nic@pzh.gov.pl
Rybicka K
No affiliation info available
Nowak I
No affiliation info available
Józefczuk J
No affiliation info available
Zycinska K
No affiliation info available
Radzikowski A
No affiliation info available
Brydak LB
No affiliation info available

MeSH

AdolescentAntibodies, ViralAntibody FormationAsthmaChildChild, PreschoolFemaleHemagglutination TestsHumansInfluenza VaccinesMaleVaccination

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18204172

Citation

Romanowska, M, et al. "Antibody Response to Influenza Vaccination in Patients Suffering From Asthma." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 58 Suppl 5, no. Pt 2, 2007, pp. 583-9.
Romanowska M, Rybicka K, Nowak I, et al. Antibody response to influenza vaccination in patients suffering from asthma. J Physiol Pharmacol. 2007;58 Suppl 5(Pt 2):583-9.
Romanowska, M., Rybicka, K., Nowak, I., Józefczuk, J., Zycinska, K., Radzikowski, A., & Brydak, L. B. (2007). Antibody response to influenza vaccination in patients suffering from asthma. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 58 Suppl 5(Pt 2), 583-9.
Romanowska M, et al. Antibody Response to Influenza Vaccination in Patients Suffering From Asthma. J Physiol Pharmacol. 2007;58 Suppl 5(Pt 2):583-9. PubMed PMID: 18204172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibody response to influenza vaccination in patients suffering from asthma. AU - Romanowska,M, AU - Rybicka,K, AU - Nowak,I, AU - Józefczuk,J, AU - Zycinska,K, AU - Radzikowski,A, AU - Brydak,L B, PY - 2008/3/28/pubmed PY - 2008/4/16/medline PY - 2008/3/28/entrez SP - 583 EP - 9 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 58 Suppl 5 IS - Pt 2 N2 - The aim of the study was to assess humoral response to influenza vaccination in 20 children with bronchial asthma vaccinated with split inactivated vaccine. Response to influenza hemagglutinin was assessed before vaccination and after 1 month by hemagglutination inhibition test. Antibody titers were significantly higher after vaccination than before vaccination. The mean fold increase of antibody levels ranged after vaccination from 12.2 to 53.7. The post-vaccination percentage of patients with protective antihemagglutinin antibody titers>or=40 ranged from 95% to 100%. The percentage of patients with at least a 4-fold increase of anthemagglutinin antibody titers ranged after vaccination from 90% to 100%. The results confirmed the immunogenicity and safety of inactivated influenza vaccine in children with asthma. The registered values of all parameters of the immunological response (mean fold increase, protection rate, response rate) fulfilled the requirements of the Committee for Proprietary Medicinal Products established for healthy people vaccinated against influenza. SN - 0867-5910 UR - https://www.unboundmedicine.com/medline/citation/18204172/Antibody_response_to_influenza_vaccination_in_patients_suffering_from_asthma_ DB - PRIME DP - Unbound Medicine ER -