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Acute in vivo evaluation of an implantable continuous flow biventricular assist system.
ASAIO J. 2008 Jan-Feb; 54(1):20-4.AJ

Abstract

An implantable biventricular assist device offers a considerable opportunity to save the lives of patients with combined irreversible right and left ventricular failure. The purpose of this study was to evaluate the hemodynamic and physiologic performance of the combined implantation of the CorAide left ventricular assist device (LVAD) and the DexAide right ventricular assist device (RVAD). Acute hemodynamic responses were evaluated after simulating seven different physiological conditions in two calves. Evaluation was performed by fixing the speed of one individual pump and increasing the speed of the other. Under all conditions, increased LVAD or RVAD speed resulted in increased pump flow. The predominant pathophysiologic effect of independently varying DexAide and CorAide pump speeds was that the left atrial pressure was very sensitive to increasing RVAD speed above 2,400 rpm, whereas the right atrial pressure demonstrated much less sensitivity to increasing LVAD speed. An increase in aortic pressure and RVAD flow was observed while increasing LVAD speed, especially under low contractility, ventricular fibrillation, high pulmonary artery pressure, and low circulatory blood volume conditions. In conclusion, a proper RVAD-LVAD balance should be maintained by avoiding RVAD overdrive. Additional studies will further investigate the performance of these pumps in chronic animal models.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Saeed D
Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA.
Ootaki Y
No affiliation info available
Ootaki C
No affiliation info available
Akiyama M
No affiliation info available
Horai T
No affiliation info available
Catanese J
No affiliation info available
Fumoto H
No affiliation info available
Dessoffy R
No affiliation info available
Massiello AL
No affiliation info available
Horvath DJ
No affiliation info available
Zhou Q
No affiliation info available
Chen JF
No affiliation info available
Benefit S
No affiliation info available
Golding LA
No affiliation info available
Fukamachi K
No affiliation info available

MeSH

AortaEquipment DesignHeart FailureHeart VentriclesHeart-Assist DevicesHemodynamicsHumansMaterials TestingModels, BiologicalMyocardial ContractionPressurePulmonary ArteryPulsatile FlowVentricular FibrillationVentricular Function

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18204311

Citation

Saeed, Diyar, et al. "Acute in Vivo Evaluation of an Implantable Continuous Flow Biventricular Assist System." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 54, no. 1, 2008, pp. 20-4.
Saeed D, Ootaki Y, Ootaki C, et al. Acute in vivo evaluation of an implantable continuous flow biventricular assist system. ASAIO J. 2008;54(1):20-4.
Saeed, D., Ootaki, Y., Ootaki, C., Akiyama, M., Horai, T., Catanese, J., Fumoto, H., Dessoffy, R., Massiello, A. L., Horvath, D. J., Zhou, Q., Chen, J. F., Benefit, S., Golding, L. A., & Fukamachi, K. (2008). Acute in vivo evaluation of an implantable continuous flow biventricular assist system. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 54(1), 20-4. https://doi.org/10.1097/MAT.0b013e31815b2d1e
Saeed D, et al. Acute in Vivo Evaluation of an Implantable Continuous Flow Biventricular Assist System. ASAIO J. 2008 Jan-Feb;54(1):20-4. PubMed PMID: 18204311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute in vivo evaluation of an implantable continuous flow biventricular assist system. AU - Saeed,Diyar, AU - Ootaki,Yoshio, AU - Ootaki,Chiyo, AU - Akiyama,Masatoshi, AU - Horai,Tetsuya, AU - Catanese,Jacquelyn, AU - Fumoto,Hideyuki, AU - Dessoffy,Raymond, AU - Massiello,Alex L, AU - Horvath,David J, AU - Zhou,Qun, AU - Chen,Ji-Feng, AU - Benefit,Stephen, AU - Golding,Leonard A R, AU - Fukamachi,Kiyotaka, PY - 2008/1/22/pubmed PY - 2008/6/19/medline PY - 2008/1/22/entrez SP - 20 EP - 4 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J VL - 54 IS - 1 N2 - An implantable biventricular assist device offers a considerable opportunity to save the lives of patients with combined irreversible right and left ventricular failure. The purpose of this study was to evaluate the hemodynamic and physiologic performance of the combined implantation of the CorAide left ventricular assist device (LVAD) and the DexAide right ventricular assist device (RVAD). Acute hemodynamic responses were evaluated after simulating seven different physiological conditions in two calves. Evaluation was performed by fixing the speed of one individual pump and increasing the speed of the other. Under all conditions, increased LVAD or RVAD speed resulted in increased pump flow. The predominant pathophysiologic effect of independently varying DexAide and CorAide pump speeds was that the left atrial pressure was very sensitive to increasing RVAD speed above 2,400 rpm, whereas the right atrial pressure demonstrated much less sensitivity to increasing LVAD speed. An increase in aortic pressure and RVAD flow was observed while increasing LVAD speed, especially under low contractility, ventricular fibrillation, high pulmonary artery pressure, and low circulatory blood volume conditions. In conclusion, a proper RVAD-LVAD balance should be maintained by avoiding RVAD overdrive. Additional studies will further investigate the performance of these pumps in chronic animal models. SN - 1538-943X UR - https://www.unboundmedicine.com/medline/citation/18204311/Acute_in_vivo_evaluation_of_an_implantable_continuous_flow_biventricular_assist_system_ DB - PRIME DP - Unbound Medicine ER -