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Development of the DexAide right ventricular assist device inflow cannula.
ASAIO J. 2008 Jan-Feb; 54(1):31-6.AJ

Abstract

Cannula design and cannulation site can pose major limitations to chronic pump implantations in animal studies. The aim of this study was to evaluate the biocompatibility of various inflow cannula designs for the DexAide right ventricular assist device (RVAD). The DexAide RVAD was implanted for intended durations of 14, 30, or 90 days in 19 animals (mean 20 +/- 11 days). Seven inflow cannula designs were evaluated: angled titanium conduit with caged tip (two cases); flexible polyurethane coated polyvinyl chloride (PVC) tube (one case); open ended titanium (one case); a titanium cannula with a flange (six cases); a cannula with a gelatin coated flange (five cases); a cannula with an angled flange (one case); and open ended titanium with two side holes (three cases). The open ended titanium inflow cannula with two side holes positioned through the diaphragmatic surface of the right ventricle (RV) via a right thoracotomy showed good biocompatibility for the chronic animal study. Other cannulae inserted into the infundibular portion of the RV via a left thoracotomy showed significant depositions. Gelatin coated inflow cannula had the advantage to prevent tissue growth around the inflow cannula. The DexAide RVAD pump itself showed good biocompatibility, although nonadherent depositions originating from the inflow cannulae were captured onto the primary impeller blades.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ootaki Y
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Saeed D
No affiliation info available
Ootaki C
No affiliation info available
Akiyama M
No affiliation info available
Fumoto H
No affiliation info available
Horai T
No affiliation info available
Dessoffy R
No affiliation info available
Catanese J
No affiliation info available
Massiello A
No affiliation info available
Horvath D
No affiliation info available
Chen JF
No affiliation info available
Benefit S
No affiliation info available
Golding LA
No affiliation info available
Fukamachi K
No affiliation info available

MeSH

AnimalsAssisted CirculationCatheterizationCattleCoated Materials, BiocompatibleEquipment DesignGelatinHeart VentriclesHeart, ArtificialHeart-Assist DevicesMaterials TestingProsthesis DesignVentricular Pressure

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18204313

Citation

Ootaki, Yoshio, et al. "Development of the DexAide Right Ventricular Assist Device Inflow Cannula." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 54, no. 1, 2008, pp. 31-6.
Ootaki Y, Saeed D, Ootaki C, et al. Development of the DexAide right ventricular assist device inflow cannula. ASAIO J. 2008;54(1):31-6.
Ootaki, Y., Saeed, D., Ootaki, C., Akiyama, M., Fumoto, H., Horai, T., Dessoffy, R., Catanese, J., Massiello, A., Horvath, D., Chen, J. F., Benefit, S., Golding, L. A., & Fukamachi, K. (2008). Development of the DexAide right ventricular assist device inflow cannula. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 54(1), 31-6. https://doi.org/10.1097/MAT.0b013e31815b3ea4
Ootaki Y, et al. Development of the DexAide Right Ventricular Assist Device Inflow Cannula. ASAIO J. 2008 Jan-Feb;54(1):31-6. PubMed PMID: 18204313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of the DexAide right ventricular assist device inflow cannula. AU - Ootaki,Yoshio, AU - Saeed,Diyar, AU - Ootaki,Chiyo, AU - Akiyama,Masatoshi, AU - Fumoto,Hideyuki, AU - Horai,Tetsuya, AU - Dessoffy,Raymond, AU - Catanese,Jacquelyn, AU - Massiello,Alex, AU - Horvath,David, AU - Chen,Ji-Feng, AU - Benefit,Stephen, AU - Golding,Leonard A R, AU - Fukamachi,Kiyotaka, PY - 2008/1/22/pubmed PY - 2008/6/19/medline PY - 2008/1/22/entrez SP - 31 EP - 6 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J VL - 54 IS - 1 N2 - Cannula design and cannulation site can pose major limitations to chronic pump implantations in animal studies. The aim of this study was to evaluate the biocompatibility of various inflow cannula designs for the DexAide right ventricular assist device (RVAD). The DexAide RVAD was implanted for intended durations of 14, 30, or 90 days in 19 animals (mean 20 +/- 11 days). Seven inflow cannula designs were evaluated: angled titanium conduit with caged tip (two cases); flexible polyurethane coated polyvinyl chloride (PVC) tube (one case); open ended titanium (one case); a titanium cannula with a flange (six cases); a cannula with a gelatin coated flange (five cases); a cannula with an angled flange (one case); and open ended titanium with two side holes (three cases). The open ended titanium inflow cannula with two side holes positioned through the diaphragmatic surface of the right ventricle (RV) via a right thoracotomy showed good biocompatibility for the chronic animal study. Other cannulae inserted into the infundibular portion of the RV via a left thoracotomy showed significant depositions. Gelatin coated inflow cannula had the advantage to prevent tissue growth around the inflow cannula. The DexAide RVAD pump itself showed good biocompatibility, although nonadherent depositions originating from the inflow cannulae were captured onto the primary impeller blades. SN - 1538-943X UR - https://www.unboundmedicine.com/medline/citation/18204313/Development_of_the_DexAide_right_ventricular_assist_device_inflow_cannula_ DB - PRIME DP - Unbound Medicine ER -