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Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma.
Cancer. 2008 Mar 01; 112(5):1037-42.C

Abstract

BACKGROUND

Pancreatic cancer risk has been linked to chronic pancreatitis and periodontitis, suggesting a role for inflammation in disease etiology. Myeloperoxidase (MPO) and superoxide dismutase (SOD2) are enzymes that regulate reactive oxygen species and contain recognized single nucleotide polymorphisms (SNPs) that confer altered enzyme activity.

METHODS

One hundred twenty-two patients with pancreatic cancer and 331 age- and sex-matched controls were analyzed for polymorphisms of the MPO - guanine 463 adenine (-G463A) and the SOD2 alanine (Ala)-to-valine (Val) polymorphism at codon 16 (Ala16Val) genes. Cases and controls were analyzed for associations between these polymorphisms, adjusting for sex, age, history of alcohol use and smoking history.

RESULTS

The variant A allele of MPO -G463A was associated with a lower risk of pancreatic cancer (adjusted odds ratio [OR] for pancreatic cancer, 0.57; 95% confidence interval [95% CI], 0.4-0.9; P = .02). The SOD2 homozygous variant genotype (Val/Val) was associated with a greater risk of pancreatic cancer (adjusted OR, 1.96; 95% CI, 1.0-3.8; P = .04). Compared with individuals who carried both low-risk alleles (A/- and Ala/-), significantly more cases than controls carried both high-risk genotypes (G/G and Val/Val; adjusted OR, 4.31; 95% CI, 1.8-10; P = .001), or 1 high-risk genotype (adjusted OR, 1.96; 95% CI, 1.1-3.4; P = .01).

CONCLUSIONS

Polymorphisms of the inflammatory pathway genes MPO -G463A and SOD2 Ala16Val are associated with elevated pancreatic cancer risk. Oxidative stress may play an important role in pancreatic cancer carcinogenesis.

Authors+Show Affiliations

Department of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18205184

Citation

Wheatley-Price, Paul, et al. "Myeloperoxidase and Superoxide Dismutase Polymorphisms Are Associated With an Increased Risk of Developing Pancreatic Adenocarcinoma." Cancer, vol. 112, no. 5, 2008, pp. 1037-42.
Wheatley-Price P, Asomaning K, Reid A, et al. Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma. Cancer. 2008;112(5):1037-42.
Wheatley-Price, P., Asomaning, K., Reid, A., Zhai, R., Su, L., Zhou, W., Zhu, A., Ryan, D. P., Christiani, D. C., & Liu, G. (2008). Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma. Cancer, 112(5), 1037-42. https://doi.org/10.1002/cncr.23267
Wheatley-Price P, et al. Myeloperoxidase and Superoxide Dismutase Polymorphisms Are Associated With an Increased Risk of Developing Pancreatic Adenocarcinoma. Cancer. 2008 Mar 1;112(5):1037-42. PubMed PMID: 18205184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma. AU - Wheatley-Price,Paul, AU - Asomaning,Kofi, AU - Reid,Amy, AU - Zhai,Rihong, AU - Su,Li, AU - Zhou,Wei, AU - Zhu,Andrew, AU - Ryan,David P, AU - Christiani,David C, AU - Liu,Geoffrey, PY - 2008/1/22/pubmed PY - 2008/3/28/medline PY - 2008/1/22/entrez SP - 1037 EP - 42 JF - Cancer JO - Cancer VL - 112 IS - 5 N2 - BACKGROUND: Pancreatic cancer risk has been linked to chronic pancreatitis and periodontitis, suggesting a role for inflammation in disease etiology. Myeloperoxidase (MPO) and superoxide dismutase (SOD2) are enzymes that regulate reactive oxygen species and contain recognized single nucleotide polymorphisms (SNPs) that confer altered enzyme activity. METHODS: One hundred twenty-two patients with pancreatic cancer and 331 age- and sex-matched controls were analyzed for polymorphisms of the MPO - guanine 463 adenine (-G463A) and the SOD2 alanine (Ala)-to-valine (Val) polymorphism at codon 16 (Ala16Val) genes. Cases and controls were analyzed for associations between these polymorphisms, adjusting for sex, age, history of alcohol use and smoking history. RESULTS: The variant A allele of MPO -G463A was associated with a lower risk of pancreatic cancer (adjusted odds ratio [OR] for pancreatic cancer, 0.57; 95% confidence interval [95% CI], 0.4-0.9; P = .02). The SOD2 homozygous variant genotype (Val/Val) was associated with a greater risk of pancreatic cancer (adjusted OR, 1.96; 95% CI, 1.0-3.8; P = .04). Compared with individuals who carried both low-risk alleles (A/- and Ala/-), significantly more cases than controls carried both high-risk genotypes (G/G and Val/Val; adjusted OR, 4.31; 95% CI, 1.8-10; P = .001), or 1 high-risk genotype (adjusted OR, 1.96; 95% CI, 1.1-3.4; P = .01). CONCLUSIONS: Polymorphisms of the inflammatory pathway genes MPO -G463A and SOD2 Ala16Val are associated with elevated pancreatic cancer risk. Oxidative stress may play an important role in pancreatic cancer carcinogenesis. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/18205184/Myeloperoxidase_and_superoxide_dismutase_polymorphisms_are_associated_with_an_increased_risk_of_developing_pancreatic_adenocarcinoma_ L2 - https://doi.org/10.1002/cncr.23267 DB - PRIME DP - Unbound Medicine ER -