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Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis.
J Periodontal Res. 2008 Jun; 43(3):360-3.JP

Abstract

BACKGROUND AND OBJECTIVE

The clinical features suggest that genetic factors may have a strong influence on susceptibility to aggressive periodontitis. The aim of this study was to investigate the association of vitamin D receptor gene polymorphisms with generalized aggressive periodontitis in Chinese patients.

MATERIAL AND METHODS

A restriction fragment length polymorphism (RFLP) for 10,438,141 C to T (rs1544410, BsmI), 10,382,063 A to G (rs731236, TaqI), 10,382,143 C to A (rs7975232, ApaI) and 10,416,201 A to G (rs2228570, FokI) of vitamin D receptor gene was analysed by polymerase chain reaction, followed by digestion with restriction enzymes and gel electrophoresis. The genotypes of 51 generalized aggressive periodontitis patients and 53 periodontally healthy control subjects were analysed. The genotypic and allelic frequencies of each polymorphism site for the patients and control subjects were compared.

RESULTS

The distribution of vitamin D receptor FokI genotypes and alleles between the two groups was significantly different (p = 0.043 and p = 0.012, respectively). The F allele seemed to increase the susceptibility of aggressive periodontitis (odds ratio = 2.02, 95% confidence interval = 1.16-3.50) in Chinese patients. There was no significant difference in the genotype distribution or the allele frequencies of vitamin D receptor BsmI, ApaI and TaqI between two groups.

CONCLUSION

The study indicates that FokI polymorphism of vitamin D receptor gene might be associated with generalized aggressive periodontitis in Chinese patients. In addition, the carriage of F allele increases the risk of developing generalized aggressive periodontitis.

Authors+Show Affiliations

Department of Stomatology, Medical School, Jinggangshan University, Ji'an, Jiangxi, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18205735

Citation

Li, S, et al. "Association of Vitamin D Receptor Gene Polymorphisms in Chinese Patients With Generalized Aggressive Periodontitis." Journal of Periodontal Research, vol. 43, no. 3, 2008, pp. 360-3.
Li S, Yang MH, Zeng CA, et al. Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis. J Periodontal Res. 2008;43(3):360-3.
Li, S., Yang, M. H., Zeng, C. A., Wu, W. L., Huang, X. F., Ji, Y., & Zeng, J. Q. (2008). Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis. Journal of Periodontal Research, 43(3), 360-3. https://doi.org/10.1111/j.1600-0765.2007.01044.x
Li S, et al. Association of Vitamin D Receptor Gene Polymorphisms in Chinese Patients With Generalized Aggressive Periodontitis. J Periodontal Res. 2008;43(3):360-3. PubMed PMID: 18205735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis. AU - Li,S, AU - Yang,M H, AU - Zeng,C A, AU - Wu,W L, AU - Huang,X F, AU - Ji,Y, AU - Zeng,J Q, Y1 - 2008/01/17/ PY - 2008/1/22/pubmed PY - 2008/6/18/medline PY - 2008/1/22/entrez SP - 360 EP - 3 JF - Journal of periodontal research JO - J Periodontal Res VL - 43 IS - 3 N2 - BACKGROUND AND OBJECTIVE: The clinical features suggest that genetic factors may have a strong influence on susceptibility to aggressive periodontitis. The aim of this study was to investigate the association of vitamin D receptor gene polymorphisms with generalized aggressive periodontitis in Chinese patients. MATERIAL AND METHODS: A restriction fragment length polymorphism (RFLP) for 10,438,141 C to T (rs1544410, BsmI), 10,382,063 A to G (rs731236, TaqI), 10,382,143 C to A (rs7975232, ApaI) and 10,416,201 A to G (rs2228570, FokI) of vitamin D receptor gene was analysed by polymerase chain reaction, followed by digestion with restriction enzymes and gel electrophoresis. The genotypes of 51 generalized aggressive periodontitis patients and 53 periodontally healthy control subjects were analysed. The genotypic and allelic frequencies of each polymorphism site for the patients and control subjects were compared. RESULTS: The distribution of vitamin D receptor FokI genotypes and alleles between the two groups was significantly different (p = 0.043 and p = 0.012, respectively). The F allele seemed to increase the susceptibility of aggressive periodontitis (odds ratio = 2.02, 95% confidence interval = 1.16-3.50) in Chinese patients. There was no significant difference in the genotype distribution or the allele frequencies of vitamin D receptor BsmI, ApaI and TaqI between two groups. CONCLUSION: The study indicates that FokI polymorphism of vitamin D receptor gene might be associated with generalized aggressive periodontitis in Chinese patients. In addition, the carriage of F allele increases the risk of developing generalized aggressive periodontitis. SN - 1600-0765 UR - https://www.unboundmedicine.com/medline/citation/18205735/Association_of_vitamin_D_receptor_gene_polymorphisms_in_Chinese_patients_with_generalized_aggressive_periodontitis_ L2 - https://doi.org/10.1111/j.1600-0765.2007.01044.x DB - PRIME DP - Unbound Medicine ER -