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Apolipoprotein E epsilon4, Alzheimer's disease, and cognitive performance in elderly Mexican Mestizos.
J Am Geriatr Soc 2008; 56(4):677-82JA

Abstract

OBJECTIVES

To determine the relationship between apolipoprotein E (APOE) epsilon4 and Alzheimer's disease (AD) in the Mexican Mestizo population, as well as its effects on the cognitive profile of AD and elderly Mestizos without dementia.

DESIGN

Cross-sectional analysis of a cohort study.

SETTING

Evaluations were conducted at the geriatrics clinic of an academic medical hospital in Mexico City.

PARTICIPANTS

Forty-nine elderly subjects with AD and 141 controls selected from a representative sample of Mexican Mestizos aged 65 to 96 who participated in the Prevalence Survey of Dementia in the Mexico City Elderly Population cohort.

MEASUREMENTS

All subjects underwent APOE genotypification and a comprehensive clinical and neuropsychological evaluation.

RESULTS

There were no significant differences in epsilon3 and epsilon4 frequencies between the subjects with and without AD and a tendency toward higher epsilon4 and lower epsilon3 allele frequencies in subjects aged 75 and older. No association was found between APOE epsilon4 and the presence of AD. The age-, sex-, and education-adjusted risk for AD associated with at least one epsilon4 allele was 1.01 (95% confidence interval=0.45-2.23). Performance on a long-term visual memory test was significantly worse in APOE epsilon4 carriers than in APOE epsilon3 carriers only in the group with AD.

CONCLUSION

APOE epsilon4 did not increase the risk for AD in this Mexican Mestizo elderly urban population sample, although the presence of this allele seems to modify its clinical expression.

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    Authors+Show Affiliations

    Villalpando-Berumen JM
    Geriatrics Clinic, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
    Mejia-Arango S
    No affiliation info available
    Aguilar-Salinas CA
    No affiliation info available
    Ordonez-Sanchez ML
    No affiliation info available
    Gutierrez-Robledo LM
    No affiliation info available

    MeSH

    AgedAged, 80 and overAllelesAlzheimer DiseaseApolipoprotein E4CognitionConfidence IntervalsCross-Sectional StudiesDNAFemaleFollow-Up StudiesGene AmplificationGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMexicoMorbidityNucleic Acid Amplification TechniquesOdds RatioUrban Population

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18205760

    Citation

    Villalpando-Berumen, Juan Manuel, et al. "Apolipoprotein E Epsilon4, Alzheimer's Disease, and Cognitive Performance in Elderly Mexican Mestizos." Journal of the American Geriatrics Society, vol. 56, no. 4, 2008, pp. 677-82.
    Villalpando-Berumen JM, Mejia-Arango S, Aguilar-Salinas CA, et al. Apolipoprotein E epsilon4, Alzheimer's disease, and cognitive performance in elderly Mexican Mestizos. J Am Geriatr Soc. 2008;56(4):677-82.
    Villalpando-Berumen, J. M., Mejia-Arango, S., Aguilar-Salinas, C. A., Ordonez-Sanchez, M. L., & Gutierrez-Robledo, L. M. (2008). Apolipoprotein E epsilon4, Alzheimer's disease, and cognitive performance in elderly Mexican Mestizos. Journal of the American Geriatrics Society, 56(4), pp. 677-82. doi:10.1111/j.1532-5415.2007.01606.x.
    Villalpando-Berumen JM, et al. Apolipoprotein E Epsilon4, Alzheimer's Disease, and Cognitive Performance in Elderly Mexican Mestizos. J Am Geriatr Soc. 2008;56(4):677-82. PubMed PMID: 18205760.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Apolipoprotein E epsilon4, Alzheimer's disease, and cognitive performance in elderly Mexican Mestizos. AU - Villalpando-Berumen,Juan Manuel, AU - Mejia-Arango,Silvia, AU - Aguilar-Salinas,Carlos Alberto, AU - Ordonez-Sanchez,Maria Luisa, AU - Gutierrez-Robledo,Luis Miguel, Y1 - 2008/01/16/ PY - 2008/1/22/pubmed PY - 2008/4/25/medline PY - 2008/1/22/entrez SP - 677 EP - 82 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 56 IS - 4 N2 - OBJECTIVES: To determine the relationship between apolipoprotein E (APOE) epsilon4 and Alzheimer's disease (AD) in the Mexican Mestizo population, as well as its effects on the cognitive profile of AD and elderly Mestizos without dementia. DESIGN: Cross-sectional analysis of a cohort study. SETTING: Evaluations were conducted at the geriatrics clinic of an academic medical hospital in Mexico City. PARTICIPANTS: Forty-nine elderly subjects with AD and 141 controls selected from a representative sample of Mexican Mestizos aged 65 to 96 who participated in the Prevalence Survey of Dementia in the Mexico City Elderly Population cohort. MEASUREMENTS: All subjects underwent APOE genotypification and a comprehensive clinical and neuropsychological evaluation. RESULTS: There were no significant differences in epsilon3 and epsilon4 frequencies between the subjects with and without AD and a tendency toward higher epsilon4 and lower epsilon3 allele frequencies in subjects aged 75 and older. No association was found between APOE epsilon4 and the presence of AD. The age-, sex-, and education-adjusted risk for AD associated with at least one epsilon4 allele was 1.01 (95% confidence interval=0.45-2.23). Performance on a long-term visual memory test was significantly worse in APOE epsilon4 carriers than in APOE epsilon3 carriers only in the group with AD. CONCLUSION: APOE epsilon4 did not increase the risk for AD in this Mexican Mestizo elderly urban population sample, although the presence of this allele seems to modify its clinical expression. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/18205760/Apolipoprotein_E_epsilon4_Alzheimer's_disease_and_cognitive_performance_in_elderly_Mexican_Mestizos_ L2 - https://doi.org/10.1111/j.1532-5415.2007.01606.x DB - PRIME DP - Unbound Medicine ER -