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Increased acylation-stimulating protein, C-reactive protein, and lipid levels in young women with polycystic ovary syndrome.
Fertil Steril. 2009 Jan; 91(1):213-9.FS

Abstract

OBJECTIVE

To evaluate potential changes that are independent of body size in the lipogenic adipokine acylation-stimulating protein (ASP), complement C3 (ASP precursor), and C-reactive protein (CRP) in subjects with polycystic ovary syndrome (PCOS).

DESIGN

Cross-sectional analysis.

SETTING

Endocrine clinic in China.

PATIENT(S)

Thirty-four women with PCOS and 41 age- and body mass index (BMI)-matched controls were recruited.

INTERVENTION(S)

Fasting blood samples were collected.

MAIN OUTCOME MEASURE(S)

Plasma glucose, insulin, lipids, ASP, C3, CRP, and homeostasis model assessment of insulin resistance were measured.

RESULT(S)

Plasma ASP, CRP, insulin, cholesterol, and nonesterified fatty acids were increased significantly in women with PCOS compared with in controls. Although each of these parameters also was statistically significantly correlated directly with BMI, the association with PCOS status was independent of BMI, with increased plasma values at all levels of BMI. In control subjects, CRP and C3 correlated with glucose and triglyceride, only CRP correlated with nonesterified fatty acids and cholesterol, and ASP correlated with triglyceride (again, all correlations were significant), whereas in subjects with PCOS, several of these correlations were lost, as a result of consistently higher levels of CRP and ASP regardless of BMI.

CONCLUSION(S)

Levels of ASP, CRP, and lipids are increased in subjects with PCOS, regardless of the level of BMI. The increased ASP level in both PCOS groups suggests that the ASP metabolism may be altered.

Authors+Show Affiliations

Department of Endocrinology, Tongji Hospital, Hua Zhong University of Science and Technology, Wuhan, Hubei, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18206145

Citation

Wu, Yuwen, et al. "Increased Acylation-stimulating Protein, C-reactive Protein, and Lipid Levels in Young Women With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 91, no. 1, 2009, pp. 213-9.
Wu Y, Zhang J, Wen Y, et al. Increased acylation-stimulating protein, C-reactive protein, and lipid levels in young women with polycystic ovary syndrome. Fertil Steril. 2009;91(1):213-9.
Wu, Y., Zhang, J., Wen, Y., Wang, H., Zhang, M., & Cianflone, K. (2009). Increased acylation-stimulating protein, C-reactive protein, and lipid levels in young women with polycystic ovary syndrome. Fertility and Sterility, 91(1), 213-9. https://doi.org/10.1016/j.fertnstert.2007.11.031
Wu Y, et al. Increased Acylation-stimulating Protein, C-reactive Protein, and Lipid Levels in Young Women With Polycystic Ovary Syndrome. Fertil Steril. 2009;91(1):213-9. PubMed PMID: 18206145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased acylation-stimulating protein, C-reactive protein, and lipid levels in young women with polycystic ovary syndrome. AU - Wu,Yuwen, AU - Zhang,Jianhua, AU - Wen,Yu, AU - Wang,Hongwei, AU - Zhang,Muxun, AU - Cianflone,Katherine, Y1 - 2008/01/18/ PY - 2007/05/31/received PY - 2007/11/14/revised PY - 2007/11/14/accepted PY - 2008/1/22/pubmed PY - 2009/1/31/medline PY - 2008/1/22/entrez SP - 213 EP - 9 JF - Fertility and sterility JO - Fertil Steril VL - 91 IS - 1 N2 - OBJECTIVE: To evaluate potential changes that are independent of body size in the lipogenic adipokine acylation-stimulating protein (ASP), complement C3 (ASP precursor), and C-reactive protein (CRP) in subjects with polycystic ovary syndrome (PCOS). DESIGN: Cross-sectional analysis. SETTING: Endocrine clinic in China. PATIENT(S): Thirty-four women with PCOS and 41 age- and body mass index (BMI)-matched controls were recruited. INTERVENTION(S): Fasting blood samples were collected. MAIN OUTCOME MEASURE(S): Plasma glucose, insulin, lipids, ASP, C3, CRP, and homeostasis model assessment of insulin resistance were measured. RESULT(S): Plasma ASP, CRP, insulin, cholesterol, and nonesterified fatty acids were increased significantly in women with PCOS compared with in controls. Although each of these parameters also was statistically significantly correlated directly with BMI, the association with PCOS status was independent of BMI, with increased plasma values at all levels of BMI. In control subjects, CRP and C3 correlated with glucose and triglyceride, only CRP correlated with nonesterified fatty acids and cholesterol, and ASP correlated with triglyceride (again, all correlations were significant), whereas in subjects with PCOS, several of these correlations were lost, as a result of consistently higher levels of CRP and ASP regardless of BMI. CONCLUSION(S): Levels of ASP, CRP, and lipids are increased in subjects with PCOS, regardless of the level of BMI. The increased ASP level in both PCOS groups suggests that the ASP metabolism may be altered. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18206145/Increased_acylation_stimulating_protein_C_reactive_protein_and_lipid_levels_in_young_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)04096-4 DB - PRIME DP - Unbound Medicine ER -