Tags

Type your tag names separated by a space and hit enter

Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis.
J Allergy Clin Immunol. 2008 Jan; 121(1):116-121.e11.JA

Abstract

BACKGROUND

Prenatal and postnatal probiotic supplementation for prevention and treatment of pediatric atopic dermatitis (PAD) has been studied in clinical trials, but results have been mixed and hindered by heterogeneity of study design.

OBJECTIVES

To summarize and interpret quantitatively clinical trial findings on the efficacy of probiotics for PAD and to define key trial features correlating with high methodologic quality.

METHODS

PubMed and Cochrane database searches yielded 21 trials (n = 1898; age 0-13 y) published between February 1997 and May 2007 for review and quality assessment. Ten double-blind randomized controlled clinical trials were meta-analyzed by using RevMan. Data from the 6 prevention studies (n = 1581) and 4 treatment trials (n = 299) were pooled by using fixed-effects and random-effects models of relative risk ratios and of weighted mean difference, respectively.

RESULTS

Prevention corresponded with summary effect sizes of 0.69 (0.57, 0.83) and 0.66 (0.49, 0.89), respectively, supporting probiotics' PAD prevention potential, which decreased further to 0.61 after exclusion of the 1 trial of postnatal-only probiotics. The clinical significance of the treatment trial findings of intergroup Scoring Atopic Dermatitis (quantification of PAD severity) score reduction by -6.64 points (-9.78, -3.49) and -8.56 (-18.39, 1.28), and intragroup change of -1.06 (-3.86, 1.73) and -1.37 (-4.81, 2.07), is questionable.

CONCLUSION

Current evidence is more convincing for probiotics' efficacy in prevention than treatment of PAD.

Authors+Show Affiliations

University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07103-2499, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

18206506

Citation

Lee, Joohee, et al. "Meta-analysis of Clinical Trials of Probiotics for Prevention and Treatment of Pediatric Atopic Dermatitis." The Journal of Allergy and Clinical Immunology, vol. 121, no. 1, 2008, pp. 116-121.e11.
Lee J, Seto D, Bielory L. Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis. J Allergy Clin Immunol. 2008;121(1):116-121.e11.
Lee, J., Seto, D., & Bielory, L. (2008). Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis. The Journal of Allergy and Clinical Immunology, 121(1), 116-e11. https://doi.org/10.1016/j.jaci.2007.10.043
Lee J, Seto D, Bielory L. Meta-analysis of Clinical Trials of Probiotics for Prevention and Treatment of Pediatric Atopic Dermatitis. J Allergy Clin Immunol. 2008;121(1):116-121.e11. PubMed PMID: 18206506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis. AU - Lee,Joohee, AU - Seto,David, AU - Bielory,Leonard, PY - 2007/08/06/received PY - 2007/10/02/revised PY - 2007/10/26/accepted PY - 2008/1/22/pubmed PY - 2008/2/26/medline PY - 2008/1/22/entrez SP - 116 EP - 121.e11 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 121 IS - 1 N2 - BACKGROUND: Prenatal and postnatal probiotic supplementation for prevention and treatment of pediatric atopic dermatitis (PAD) has been studied in clinical trials, but results have been mixed and hindered by heterogeneity of study design. OBJECTIVES: To summarize and interpret quantitatively clinical trial findings on the efficacy of probiotics for PAD and to define key trial features correlating with high methodologic quality. METHODS: PubMed and Cochrane database searches yielded 21 trials (n = 1898; age 0-13 y) published between February 1997 and May 2007 for review and quality assessment. Ten double-blind randomized controlled clinical trials were meta-analyzed by using RevMan. Data from the 6 prevention studies (n = 1581) and 4 treatment trials (n = 299) were pooled by using fixed-effects and random-effects models of relative risk ratios and of weighted mean difference, respectively. RESULTS: Prevention corresponded with summary effect sizes of 0.69 (0.57, 0.83) and 0.66 (0.49, 0.89), respectively, supporting probiotics' PAD prevention potential, which decreased further to 0.61 after exclusion of the 1 trial of postnatal-only probiotics. The clinical significance of the treatment trial findings of intergroup Scoring Atopic Dermatitis (quantification of PAD severity) score reduction by -6.64 points (-9.78, -3.49) and -8.56 (-18.39, 1.28), and intragroup change of -1.06 (-3.86, 1.73) and -1.37 (-4.81, 2.07), is questionable. CONCLUSION: Current evidence is more convincing for probiotics' efficacy in prevention than treatment of PAD. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/18206506/Meta_analysis_of_clinical_trials_of_probiotics_for_prevention_and_treatment_of_pediatric_atopic_dermatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(07)02172-0 DB - PRIME DP - Unbound Medicine ER -