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Combination of the enuresis alarm and desmopressin: second line treatment for nocturnal enuresis.
J Urol. 2008 Mar; 179(3):1128-31.JU

Abstract

PURPOSE

We sought to evaluate the combination of the enuresis alarm and desmopressin in treating children with enuresis.

MATERIALS AND METHODS

A retrospective analysis was performed on data from 423 children treated at our clinics with the enuresis alarm during the years 2000 to 2004. Frequency volume charts and desmopressin titration facilitated characterization of the participants using the current International Children's Continence Society standardization. Children were treated with the enuresis alarm as monotherapy before the addition of desmopressin, which commenced after 6 weeks in patients exhibiting inadequate response to alarm or after 2 weeks in patients experiencing multiple enuretic episodes per night or showing no indication of improvement.

RESULTS

Of the initial population 315 children (74%) were treated only with alarm, of whom 290 became dry. A total of 108 children (26%) were treated with a combination of alarm and desmopressin, with 80 being cured. Children dry on alarm therapy were not different from those needing the addition of desmopressin in terms of demographics. Children dry on desmopressin plus alarm had higher average nocturnal urine production on wet nights (303 +/- 12 ml compared to 269 +/- 5 ml, p <0.001). Maximum voided volume before treatment corrected for age was not different between children dry on alarm and those dry on combination therapy (0.84 +/- 0.02 compared to 0.86 +/- 0.05, not significant).

CONCLUSIONS

Children needing the addition of desmopressin have a higher nocturnal urine production on wet nights but do not seem to differ in terms of bladder reservoir function characteristics.

Authors+Show Affiliations

Clinical Institute, University of Aarhus and Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark. kostas.kamperis@ki.au.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18206924

Citation

Kamperis, Konstantinos, et al. "Combination of the Enuresis Alarm and Desmopressin: Second Line Treatment for Nocturnal Enuresis." The Journal of Urology, vol. 179, no. 3, 2008, pp. 1128-31.
Kamperis K, Hagstroem S, Rittig S, et al. Combination of the enuresis alarm and desmopressin: second line treatment for nocturnal enuresis. J Urol. 2008;179(3):1128-31.
Kamperis, K., Hagstroem, S., Rittig, S., & Djurhuus, J. C. (2008). Combination of the enuresis alarm and desmopressin: second line treatment for nocturnal enuresis. The Journal of Urology, 179(3), 1128-31. https://doi.org/10.1016/j.juro.2007.10.088
Kamperis K, et al. Combination of the Enuresis Alarm and Desmopressin: Second Line Treatment for Nocturnal Enuresis. J Urol. 2008;179(3):1128-31. PubMed PMID: 18206924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of the enuresis alarm and desmopressin: second line treatment for nocturnal enuresis. AU - Kamperis,Konstantinos, AU - Hagstroem,Soren, AU - Rittig,Soren, AU - Djurhuus,Jens C, Y1 - 2008/01/18/ PY - 2007/07/04/received PY - 2008/1/22/pubmed PY - 2008/3/20/medline PY - 2008/1/22/entrez SP - 1128 EP - 31 JF - The Journal of urology JO - J Urol VL - 179 IS - 3 N2 - PURPOSE: We sought to evaluate the combination of the enuresis alarm and desmopressin in treating children with enuresis. MATERIALS AND METHODS: A retrospective analysis was performed on data from 423 children treated at our clinics with the enuresis alarm during the years 2000 to 2004. Frequency volume charts and desmopressin titration facilitated characterization of the participants using the current International Children's Continence Society standardization. Children were treated with the enuresis alarm as monotherapy before the addition of desmopressin, which commenced after 6 weeks in patients exhibiting inadequate response to alarm or after 2 weeks in patients experiencing multiple enuretic episodes per night or showing no indication of improvement. RESULTS: Of the initial population 315 children (74%) were treated only with alarm, of whom 290 became dry. A total of 108 children (26%) were treated with a combination of alarm and desmopressin, with 80 being cured. Children dry on alarm therapy were not different from those needing the addition of desmopressin in terms of demographics. Children dry on desmopressin plus alarm had higher average nocturnal urine production on wet nights (303 +/- 12 ml compared to 269 +/- 5 ml, p <0.001). Maximum voided volume before treatment corrected for age was not different between children dry on alarm and those dry on combination therapy (0.84 +/- 0.02 compared to 0.86 +/- 0.05, not significant). CONCLUSIONS: Children needing the addition of desmopressin have a higher nocturnal urine production on wet nights but do not seem to differ in terms of bladder reservoir function characteristics. SN - 1527-3792 UR - https://www.unboundmedicine.com/medline/citation/18206924/Combination_of_the_enuresis_alarm_and_desmopressin:_second_line_treatment_for_nocturnal_enuresis_ L2 - https://www.jurology.com/doi/10.1016/j.juro.2007.10.088?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -